Publications - Tobias Bonhoeffer



Kaschube M, Nelson CA, Benasich AA, Buzsáki G, Gressens P, Hensck TK, Hübener M, Kobor MS, Singer W and Sur M (2018). Early Childhood. In A. A.Benasich and U.Ribary (eds): Emergent Brain Dynamics: Prebirth to Adolescence, pp 102-123. Cambridge, MA: The MIT Press. Series: Strüngmann Forum Reports, Vol.25.

Weiler, S, Bauer J, Hübener M, Bonhoeffer T, Rose T, Scheuss V (2018). High-yield in vitro recordings from neurons functionally characterized in vivo. Nature Protocols 13:1275-1293. doi:10.1038/nprot.2018.026

Rose T, Bonhoeffer T (2018). Experience-dependent plasticity in the lateral geniculate nucleus. Curr Opin Neurobiol 53: 22-28.

Scheuss V (2018). Quantitative analysis of the spatial organization of synaptic inputs on the postsynaptic dendrite. Frontiers in Neural Circuits 12. doi: 10.3389/fncir.2018.00039


Jäpel J, Hübener M, Bonhoeffer T, Rose T (2017). Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice. Nat Neurosci 20: 1708-1714

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT (2017). Building Bridges through Science. Neuron 96(4): 730-735. doi: 10.1016/j.neuron.2017.09.28

Clopath C, Bonhoeffer T, Hübener M, Rose T (2017). Variance and invariance of neuronal long-term representations. Phil. Trans. R. Soc. B 372:20160161.

Keck T, Hübener M, Bonhoeffer T (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Curr Opin Neurobiol 43: 87-93.


Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M* (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539: 248-253. * equal contribution

Gökçe O, Bonhoeffer T, Scheuss V (2016). Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex. eLife 09222:doi: 10.7554/eLife.09222

Rose T, Jäpel J, Hübener M, Bonhoeffer T (2016). Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352: 1319-1322

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016). Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice. Current Biol 26: 956-964


Müllner FE, Wierenga CJ, Bonhoeffer T (2015). Precision of inhibition: dendritic inhibition by individual GABAergic synapses on hippocampal pyramidal cells is confined in space and time. Neuron 87: 576-589. doi: 10.1016/j.neuron.2015.07.003.


Hübener M, Bonhoeffer T (2014). Neuronal plasticity: beyond the critical period. Cell 159: 727-737

Moser EI, Roudi Y, Witter MP, Kentros C, Bonhoeffer T, Moser M-B (2014). Grid cells and cortical representation. Nat Rev Neurosci 7: 466-481. doi: 10.1038/nrn3766

Meyer D, Bonhoeffer T, Scheuss V (2014). Balance and stability of synaptic structures during synaptic plasticity. Neuron 82: 430-443


Keck T*, Keller GB*, Jacobsen RI*, Eysel UT, Bonhoeffer T, Hübener M (2013). Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo. Neuron 80: 327-334
* equal contribution

Schuemann A, Klawiter A, Bonhoeffer T, Wierenga CJ (2013). Structural plasticity of GABAergic axons is regulated by network activity and GABAA receptor activation. Front Neural Circuits 7: 113, doi:10.3389/fncir.2013.00113

Scheuss V, Bonhoeffer T (2013). Function of dendritic spines on hippocampal inhibitory neurons. Cereb Cortex, doi:10.1093/cercor/bht171

Liebscher S, Page R, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Guriqbal SB, Schenk B, Steiner H, Bonhoeffer T, Haass, C, Meyer-Luehmann M, Hübener M (2013). Chronic  γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry, doi: 10.1038/mp.2013.122


Tomita T, Sperling M, Cambridge SB, Bonhoeffer T, Hübener M (2012). A molecular correlate of ocular dominance columns in the developing mammalian visual cortex. Cereb Cortex, doi:10.1093/cercor/bhs232

Levelt CN, Hübener M (2012). Critical-period plasticity in the visual cortex. Annu Rev Neurosci 21: 309-330

Keller GB, Bonhoeffer T, Hübener M (2012). Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron 74: 809-815


Kleindienst T, Winnubst J, Roth-Alpermann C, Bonhoeffer T, Lohmann C (2011). Activity-dependent clustering of functional synaptic inputs on developing hippocampal dendrites. Neuron 72: 1012-1024

Kreile AK, Bonhoeffer T, Hübener M (2011). Altered visual experience induces instructive changes of orientation preference in mouse visual cortex. J Neurosci 31: 13911-13920

Keck T, Scheuss V, Jacobsen RI, Wierenga CJ, Eysel UT, Bonhoeffer T, Hübener M (2011). Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. Neuron 71: 869-882


Wierenga CJ, Müllner FE, Rinke I, Keck T, Stein V, Bonhoeffer T (2010). Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice. PloS One 5: 1-11

Hofer SB and T Bonhoeffer (2010). Dendritic spines: the stuff that memories are made of? Curr Biol 20: R157-R159

Hübener M, Bonhoeffer T (2010). Searching for Engrams. Neuron 67: 363-371

Nägerl UV and T Bonhoeffer (2010). Imaging living synapses at the nanoscale by STED microscopy. J Neurosci 30: 9341-9346


Holtmaat A, Bonhoeffer T, Chow D, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee W-CA, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009). Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nature Protocols 4: 1128-1144

Cambridge SB, Geissler D, Calegari F, Anastassiadis K, Hasan MT, Stewart AF, Huttner WB, Hagen V, Bonhoeffer T (2009). Doxycycline-dependent photoactivated gene expression in eukaryotic systems. Nature Methods 6: 527-531

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009). Experience leaves a lasting structural trace in cortical circuits. Nature 457: 313-317

Albantakis L, Lohmann C (2009). A simple method for quantitative calcium imaging in unperturbed developing neurons. Journal of Neuroscience Methods 184: 206-212


Nägerl UV, Willig KI, Hein B, Hell SW, Bonhoeffer T (2008). Live-cell imaging of dendritic spines by STED microscopy. Proc. Natl. Acad. Sci. USA 105: 18982-18987

Becker N, Wierenga CJ*, Fonseca R*, Bonhoeffer T, Nägerl UV (2008). LTD induction causes morphological changes of presynaptic boutons and reduces their contacts with spines. Neuron 60: 590-597. *equal contributions

Mank M, Ferrão Santos A, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T,  Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O (2008). A genetically encoded calcium indicator for chronic in vivo two photon imaging. Nature Methods 5: 805-811

Keck T, Mrsic-Flogel TD, Vaz Afonso M, Eysel UT, Bonhoeffer T, Hübener M (2008). Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci 11: 1162-1167

Wierenga CJ, Becker N, Bonhoeffer T (2008). GABAergic synapses are formed without the involvement of dendritic protrusions. Nat Neurosci 11: 1044-1052

Lohmann C, Bonhoeffer T (2008). A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia. Neuron 59: 253-260


Kossel AH (2007). Neuronal sandwiches: a method for rapid and controlled initiation of synapses. J Neurosci Methods 166: 241-249

Lucic V, Kossel AH, Yang T, Bonhoeffer T, Baumeister W, Sartori A (2007). Multiscale imaging of neurons grown in culture: from light microscopy to cryo-electron tomography. J Struct Biol 160: 146-156

Nägerl, UV, Köstinger G, Anderson J, Martin KAC, Bonhoeffer T (2007). Protracted synaptogenesis after activity-dependent spinogenesis in hippocampal neurons. J Neurosci 27: 8149-8156

Mrsic-Flogel T, Hofer SB, Ohki K, Reid RC, Bonhoeffer T, Hübener M (2007). Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron 54: 961-972

Lang SB, Stein V, Bonhoeffer T, Lohmann C(2007). Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites. J Neurosci 27: 1097-1105


Fonseca R, Vabulas RM, Hartl FU, Bonhoeffer T, Nägerl UV (2006). A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 52: 239-245

Ohki K, Chung S, Kara P, Hübener M, Bonhoeffer T, Reid RC (2006). Highly ordered arrangement of single neurons in orientation pinwheels. Nature 442: 925-929

Roth-Alpermann C, Morris R, Korte M, Bonhoeffer T (2006). Homeostatic shutdown of long-term potentiation in the adult hippocampus. Proc Natl Acad Sci USA 103: 11039-11044

Gartner A, Polnau DG, Staiger V, Sciarretta C, Minichiello L, Thoenen H, Bonhoeffer T, Korte M (2006). Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase C gamma signaling. J Neurosci 26: 3496-3504

Fonseca R, Nägerl UV, Bonhoeffer T (2006). Neuronal Activity determines the protein synthesis-dependence of LTP. Nat Neurosci 9: 478-480

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Prior experience enhances plasticity in adult visual cortex. Nat Neurosci 9: 127-132


Mrsic-Flogel TD, Hofer SB, Creutzfeldt C, Cloez-Tayarani I, Changeux JP, Bonhoeffer T, Hübener M (2005). Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci 25: 6921-6928

Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, Flügel A (2005). Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med 201: 1805-1814

Zagrebelsky M, Holz A, Dechant G, Barde YA, Bonhoeffer T, Korte M (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neurosci 25: 9989-9999

Lohmann C, Finski A, Bonhoeffer T (2005). Local calcium transients regulate the spontaneous motility of dendritic filopodia. Nat Neurosci 8: 305-312


Fonseca R, Nägerl UV, Morris RG, Bonhoeffer T (2004). Competing for memory: hippocampal LTP under regimes of reduced protein synthesis. Neuron 44: 1011-1020

Nägerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T (2004). Bidirectional activity-dependent morphological plasticity in hippocampal neurons. Neuron 44: 759-767

Grinvald A, Bonhoeffer T, Vanzetta I, Pollack A, Aloni E, Ofri R, Nelson D (2004). High-resolution functional optical imaging: from the neocortex to the eye. Ophthalmol Clin North Am 17: 53-67

Yuste R, Bonhoeffer T (2004). Genesis of dendritic spines: Insights from ultrastructural and imaging studies. Nat Rev Neurosci 5: 24-34

Grunwald IC, Korte M, Adelmann G, Plueck A, Kullander K, Adams R, Frotscher M, Bonhoeffer T*, Klein R* (2004). Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7: 33-40


Mrsic-Flogel T, Hübener M, Bonhoeffer T (2003). Brain mapping: new wave optical imaging. Curr Biol 13: R778-R780

Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Good Stefani G, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, Mundel P(2003). Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci USA 100: 10494-10499


Kind PC, Mitchell DE, Ahmed B, Blakemore C, Bonhoeffer T, Sengpiel F (2002). Correlated binocular activity guides recovery from monocular deprivation. Nature 416: 430-433

Schuett S, Bonhoeffer T, Hübener M (2002). Mapping retinotopic structure in mouse visual cortex with optical imaging. J Neurosci 22: 6549-6559

Minichiello L, AM Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M (2002). Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 36: 121-137

Bonhoeffer T, Yuste R (2002). Spine motility: phenomenology, mechanisms and function. Neuron 35: 1019-1027

Sengpiel F, Bonhoeffer T (2002). Orientation specificity of contrast adaptation in visual cortical pinwheel centres and iso-orientation domains. Eur. J Neurosci 15: 876-886


Kossel A, Cambridge SB, Wagner U, Bonhoeffer T (2001). A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation. Proc Natl Acad Sci USA  98: 14702-14707

Sengpiel F, Freeman TCB, Bonhoeffer T, Blakemore C (2001). On the relationship between interocular suppression in the primary visual cortex and binocular rivalry. Brain and Mind 2: 39-54

Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R (2001). Kinase-independent requirement of EhB2 receptors in hippocampal synaptic plasticity. Neuron 32: 1027-1040

Schwartz T, Bonhoeffer T (2001). In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex. Nat Med 7: 1063-1067

Yuste R, Bonhoeffer T (2001). Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24: 1071-1089

Meister M, Bonhoeffer T (2001). Tuning and topography in an odor map on the rat olfactory bulb. J Neurosci 21: 1351-1360


Swindale NV, Shoham D, Grinvald A, Bonhoeffer T, Hübener M (2000). Visual cortex maps are optimized for uniform coverage. Nat Neurosci 3: 822-826

Müller M, Stetter M, Hübener M, Sengpiel F, Bonhoeffer T, Gödecke I, Chapman B, Löwel S, Obermayer K (2000). An analysis of orientation and ocular dominance patterns in the visual cortex of cats and ferrets. Neural Comput  12: 2574-2595

Stetter M, Schießl I, Otto T, Sengpiel F, Hübener M, Bonhoeffer T, Obermayer K (2000). Principal component analysis and blind separation of sources for optical imaging of intrinsic signals. Neuroimage 11: 482-490

Korte M, Minichiello L, Klein R, Bonhoeffer T (2000). Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation. Neuropharmacol 39: 717-724


Hübener M, Bonhoeffer T (1999). Eyes wide shut. Nat. Neurosci. 2: 1043-1045

Minichiello L, Korte M, Wolfer D, Kühn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp H-P, Bonhoeffer T, Klein R (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24: 401-414

Sengpiel F, Stawinski P, Bonhoeffer T (1999). Influence of experience on orientation maps in cat visual cortex. Nat Neurosci 2: 727-732

Engert F, Bonhoeffer T (1999). Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399: 66-70

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