Publications - Tobias Bonhoeffer



Clopath, C, Bonhoeffer T, Hübener M, Rose T (2017). Variance and invariance of neuronal long-term representations. Phil. Trans. R. Soc. B 372:20160161.

Keck T, Hübener M, Bonhoeffer T (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Curr Opin Neurobiol 43: 87-93.


Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M* (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539: 248-253. * equal contribution

Gökçe O, Bonhoeffer T, Scheuss V (2016). Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex. eLife 09222:doi: 10.7554/eLife.09222

Rose T, Jaepel J, Hübener M, Bonhoeffer T (2016). Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352: 1319-1322

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016). Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice. Current Biol 26: 956-964


Müllner FE, Wierenga CJ, Bonhoeffer T (2015). Precision of inhibition: dendritic inhibition by individual GABAergic synapses on hippocampal pyramidal cells is confined in space and time. Neuron 87: 576-589. doi: 10.1016/j.neuron.2015.07.003.


Hübener M, Bonhoeffer T (2014). Neuronal plasticity: beyond the critical period. Cell 159: 727-737

Moser EI, Roudi Y, Witter MP, Kentros C, Bonhoeffer T, Moser M-B (2014). Grid cells and cortical representation. Nat Rev Neurosci 7: 466-481. doi: 10.1038/nrn3766

Meyer D, Bonhoeffer T, Scheuss V (2014). Balance and stability of synaptic structures during synaptic plasticity. Neuron 82: 430-443


Keck T*, Keller GB*, Jacobsen RI*, Eysel UT, Bonhoeffer T, Hübener M (2013). Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo. Neuron 80: 327-334
* equal contribution

Schuemann A, Klawiter A, Bonhoeffer T, Wierenga CJ (2013). Structural plasticity of GABAergic axons is regulated by network activity and GABAA receptor activation. Front Neural Circuits 7: 113, doi:10.3389/fncir.2013.00113

Scheuss V, Bonhoeffer T (2013). Function of dendritic spines on hippocampal inhibitory neurons. Cereb Cortex, doi:10.1093/cercor/bht171

Liebscher S, Page R, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Guriqbal SB, Schenk B, Steiner H, Bonhoeffer T, Haass, C, Meyer-Luehmann M, Hübener M (2013). Chronic  γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry, doi: 10.1038/mp.2013.122


Tomita T, Sperling M, Cambridge SB, Bonhoeffer T, Hübener M (2012). A molecular correlate of ocular dominance columns in the developing mammalian visual cortex. Cereb Cortex, doi:10.1093/cercor/bhs232

Levelt CN, Hübener M (2012). Critical-period plasticity in the visual cortex. Annu Rev Neurosci 21: 309-330

Keller GB, Bonhoeffer T, Hübener M (2012). Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron 74: 809-815


Kleindienst T, Winnubst J, Roth-Alpermann C, Bonhoeffer T, Lohmann C (2011). Activity-dependent clustering of functional synaptic inputs on developing hippocampal dendrites. Neuron 72: 1012-1024

Kreile AK, Bonhoeffer T, Hübener M (2011). Altered visual experience induces instructive changes of orientation preference in mouse visual cortex. J Neurosci 31: 13911-13920

Keck T, Scheuss V, Jacobsen RI, Wierenga CJ, Eysel UT, Bonhoeffer T, Hübener M (2011). Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. Neuron 71: 869-882


Wierenga CJ, Müllner FE, Rinke I, Keck T, Stein V, Bonhoeffer T (2010). Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice. PloS One 5: 1-11

Hofer SB and T Bonhoeffer (2010). Dendritic spines: the stuff that memories are made of? Curr Biol 20: R157-R159

Hübener M, Bonhoeffer T (2010). Searching for Engrams. Neuron 67: 363-371

Nägerl UV and T Bonhoeffer (2010). Imaging living synapses at the nanoscale by STED microscopy. J Neurosci 30: 9341-9346


Holtmaat A, Bonhoeffer T, Chow D, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee W-CA, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009). Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nature Protocols 4: 1128-1144

Cambridge SB, Geissler D, Calegari F, Anastassiadis K, Hasan MT, Stewart AF, Huttner WB, Hagen V, Bonhoeffer T (2009). Doxycycline-dependent photoactivated gene expression in eukaryotic systems. Nature Methods 6: 527-531

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009). Experience leaves a lasting structural trace in cortical circuits. Nature 457: 313-317

Albantakis L, Lohmann C (2009). A simple method for quantitative calcium imaging in unperturbed developing neurons. Journal of Neuroscience Methods 184: 206-212


Nägerl UV, Willig KI, Hein B, Hell SW, Bonhoeffer T (2008). Live-cell imaging of dendritic spines by STED microscopy. Proc. Natl. Acad. Sci. USA 105: 18982-18987

Becker N, Wierenga CJ*, Fonseca R*, Bonhoeffer T, Nägerl UV (2008). LTD induction causes morphological changes of presynaptic boutons and reduces their contacts with spines. Neuron 60: 590-597. *equal contributions

Mank M, Ferrão Santos A, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T,  Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O (2008). A genetically encoded calcium indicator for chronic in vivo two photon imaging. Nature Methods 5: 805-811

Keck T, Mrsic-Flogel TD, Vaz Afonso M, Eysel UT, Bonhoeffer T, Hübener M (2008). Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci 11: 1162-1167

Wierenga CJ, Becker N, Bonhoeffer T (2008). GABAergic synapses are formed without the involvement of dendritic protrusions. Nat Neurosci 11: 1044-1052

Lohmann C, Bonhoeffer T (2008). A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia. Neuron 59: 253-260


Kossel AH (2007). Neuronal sandwiches: a method for rapid and controlled initiation of synapses. J Neurosci Methods 166: 241-249

Lucic V, Kossel AH, Yang T, Bonhoeffer T, Baumeister W, Sartori A (2007). Multiscale imaging of neurons grown in culture: from light microscopy to cryo-electron tomography. J Struct Biol 160: 146-156

Nägerl, UV, Köstinger G, Anderson J, Martin KAC, Bonhoeffer T (2007). Protracted synaptogenesis after activity-dependent spinogenesis in hippocampal neurons. J Neurosci 27: 8149-8156

Mrsic-Flogel T, Hofer SB, Ohki K, Reid RC, Bonhoeffer T, Hübener M (2007). Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron 54: 961-972

Lang SB, Stein V, Bonhoeffer T, Lohmann C(2007). Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites. J Neurosci 27: 1097-1105


Fonseca R, Vabulas RM, Hartl FU, Bonhoeffer T, Nägerl UV (2006). A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 52: 239-245

Ohki K, Chung S, Kara P, Hübener M, Bonhoeffer T, Reid RC (2006). Highly ordered arrangement of single neurons in orientation pinwheels. Nature 442: 925-929

Roth-Alpermann C, Morris R, Korte M, Bonhoeffer T (2006). Homeostatic shutdown of long-term potentiation in the adult hippocampus. Proc Natl Acad Sci USA 103: 11039-11044

Gartner A, Polnau DG, Staiger V, Sciarretta C, Minichiello L, Thoenen H, Bonhoeffer T, Korte M (2006). Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase C gamma signaling. J Neurosci 26: 3496-3504

Fonseca R, Nägerl UV, Bonhoeffer T (2006). Neuronal Activity determines the protein synthesis-dependence of LTP. Nat Neurosci 9: 478-480

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Prior experience enhances plasticity in adult visual cortex. Nat Neurosci 9: 127-132


Mrsic-Flogel TD, Hofer SB, Creutzfeldt C, Cloez-Tayarani I, Changeux JP, Bonhoeffer T, Hübener M (2005). Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci 25: 6921-6928

Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, Flügel A (2005). Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med 201: 1805-1814

Zagrebelsky M, Holz A, Dechant G, Barde YA, Bonhoeffer T, Korte M (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neurosci 25: 9989-9999

Lohmann C, Finski A, Bonhoeffer T (2005). Local calcium transients regulate the spontaneous motility of dendritic filopodia. Nat Neurosci 8: 305-312


Fonseca R, Nägerl UV, Morris RG, Bonhoeffer T (2004). Competing for memory: hippocampal LTP under regimes of reduced protein synthesis. Neuron 44: 1011-1020

Nägerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T (2004). Bidirectional activity-dependent morphological plasticity in hippocampal neurons. Neuron 44: 759-767

Grinvald A, Bonhoeffer T, Vanzetta I, Pollack A, Aloni E, Ofri R, Nelson D (2004). High-resolution functional optical imaging: from the neocortex to the eye. Ophthalmol Clin North Am 17: 53-67

Yuste R, Bonhoeffer T (2004). Genesis of dendritic spines: Insights from ultrastructural and imaging studies. Nat Rev Neurosci 5: 24-34

Grunwald IC, Korte M, Adelmann G, Plueck A, Kullander K, Adams R, Frotscher M, Bonhoeffer T*, Klein R* (2004). Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7: 33-40


Mrsic-Flogel T, Hübener M, Bonhoeffer T (2003). Brain mapping: new wave optical imaging. Curr Biol 13: R778-R780

Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Good Stefani G, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, Mundel P(2003). Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci USA 100: 10494-10499


Kind PC, Mitchell DE, Ahmed B, Blakemore C, Bonhoeffer T, Sengpiel F (2002). Correlated binocular activity guides recovery from monocular deprivation. Nature 416: 430-433

Schuett S, Bonhoeffer T, Hübener M (2002). Mapping retinotopic structure in mouse visual cortex with optical imaging. J Neurosci 22: 6549-6559

Minichiello L, AM Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M (2002). Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 36: 121-137

Bonhoeffer T, Yuste R (2002). Spine motility: phenomenology, mechanisms and function. Neuron 35: 1019-1027

Sengpiel F, Bonhoeffer T (2002). Orientation specificity of contrast adaptation in visual cortical pinwheel centres and iso-orientation domains. Eur. J Neurosci 15: 876-886


Kossel A, Cambridge SB, Wagner U, Bonhoeffer T (2001). A caged Ab reveals an immediate/instructive effect of BDNF during hippocampal synaptic potentiation. Proc Natl Acad Sci USA  98: 14702-14707

Sengpiel F, Freeman TCB, Bonhoeffer T, Blakemore C (2001). On the relationship between interocular suppression in the primary visual cortex and binocular rivalry. Brain and Mind 2: 39-54

Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R (2001). Kinase-independent requirement of EhB2 receptors in hippocampal synaptic plasticity. Neuron 32: 1027-1040

Schwartz T, Bonhoeffer T (2001). In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex. Nat Med 7: 1063-1067

Yuste R, Bonhoeffer T (2001). Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annu Rev Neurosci 24: 1071-1089

Meister M, Bonhoeffer T (2001). Tuning and topography in an odor map on the rat olfactory bulb. J Neurosci 21: 1351-1360


Swindale NV, Shoham D, Grinvald A, Bonhoeffer T, Hübener M (2000). Visual cortex maps are optimized for uniform coverage. Nat Neurosci 3: 822-826

Müller M, Stetter M, Hübener M, Sengpiel F, Bonhoeffer T, Gödecke I, Chapman B, Löwel S, Obermayer K (2000). An analysis of orientation and ocular dominance patterns in the visual cortex of cats and ferrets. Neural Comput  12: 2574-2595

Stetter M, Schießl I, Otto T, Sengpiel F, Hübener M, Bonhoeffer T, Obermayer K (2000). Principal component analysis and blind separation of sources for optical imaging of intrinsic signals. Neuroimage 11: 482-490

Korte M, Minichiello L, Klein R, Bonhoeffer T (2000). Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation. Neuropharmacol 39: 717-724


Hübener M, Bonhoeffer T (1999). Eyes wide shut. Nat. Neurosci. 2: 1043-1045

Minichiello L, Korte M, Wolfer D, Kühn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp H-P, Bonhoeffer T, Klein R (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24: 401-414

Sengpiel F, Stawinski P, Bonhoeffer T (1999). Influence of experience on orientation maps in cat visual cortex. Nat Neurosci 2: 727-732

Engert F, Bonhoeffer T (1999). Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399: 66-70

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