Publications - Rüdiger Klein


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Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W and Fernández-Busnadiego R. (2017). In situ Architecture and Cellular Interactions of PolyQ Inclusions. Cell, in press.

Douglass AM#, Kucukdereli H#, Ponserre M#, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann KK, Lüthi A, Klein R (2017) Central amygdala circuits modulate food consumption through a positive valence mechanism. Nature Neuroscience, in press. # equal contribution

Del Toro D#, Ruff T#, Cederfjäll E, Villalba A, Seyit-Bremer G, Borrell V, Klein R (2017) Regulation of cerebral cortex folding by controlling neuronal migration via FLRT adhesion molecules. Cell, 169, 612-635. # equal contribution
DOI:, Recommended in F1000Prime

Yoshikawa Y, Tai-Nagara I, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, Kubota Y. (2017). Placental labyrinth formation requires inter-endothelial repulsion mediated by FLRT2/UNC5B signaling. Development, 144 (13):2392-2401 
doi: 10.1242/dev.149757

Hunt S, Sun Y, Kucukdereli H, Klein R, and Sah P. (2017). Intrinsic circuits in the lateral central amygdala. eNeuro, Mar 24;4(1). doi: 10.1523/ENEURO.0367-16.2017.


Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, Andersson L, Pettersson H, Wölfl S, Klein R, Oxburgh L, Kullander K. (2016). Multimodal Eph/Ephrin signaling controls several phases of urogenital development. Kidney Int., Aug;90(2):373-88. doi: 10.1016/j.kint.2016.04.021.

Seiradake E, Jones EY, Klein R. (2016). Structural Perspectives on Axon Guidance. Annual Review of Cell and Developmental Biology, Oct 6;32:577-608.

Gaitanos TN*#, Koerner J#, Klein R*. (2016). Tiam/Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. Journal of Cell Biology, 214:735-752. *corresponding authors, # equal contribution

Kania, A. and Klein, R. (2016). Mechanisms of ephrin–Eph signaling in development, physiology and disease. Nat. Rev. Mol. Cell Biol., Apr;17(4):240-56. doi: 10.1038/nrm.2015.16.

Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MSP, Robinson CV, Klein R, Seiradake E. (2016). Super-complexes of adhesion GPCRs and neural guidance receptors. Nat. Comm., Apr 19;7:11184. doi: 10.1038/ncomms11184.

Gong, J., Körner, R., Gaitanos, L., and Klein, R. (2016). Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. Journal of Cell Biology, Jul 4;214(1):35-44. doi: 10.1083/jcb.201601085. Spotlight in JCB by E. Pasquale “Exosomes expand the sphere of influence of Eph receptors and ephrins”; recommended in F1000Prime.


Jackson, V.A., del Toro, D., Carrasquero, M., Roversi, P., Harlos, K., Klein, R., Seiradake, E. (2015). Structural basis of Latrophilin-FLRT interaction. Structure 23,1-8.

Fleming, M.S., Vysochan, A., Paixão, P.,  Niu, J., Klein, R., Savitt, J.M., Luo, W. (2015). Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. eLife 2015;10.7554/eLife.06828

Gaitanos, T., Dudanova, I., Sakkou, M., Klein, R., Paixão, P. (2015). The Eph Receptor Family in Receptor Tyrosine Kinases: Family and Subfamilies, Edited by Deric L. Wheeler and Yosef Yarden (Springer International Publishing Switzerland), 165-264. DOI 10.1007/978-3-319-11888-8_5


Seiradake, E.#, del Toro, D.#, Nagel, D., Cop, F., Härtl, R., Ruff, T., Seyit-Bremer, G., Harlos, K., Border, E.C., Acker-Palmer, A., Jones, E.Y*., Klein, R*. FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84, 370-385 *corresponding authors, # equal contribution
Open access: download pdf

Gatto, G., Morales, D., Kania, A., Klein, R. (2014). EphA4 receptor shedding regulates spinal motor axon guidance. Current Biology, Sept 24,

Serradj N, Paixao S, Sobocki T, Feinberg M, Klein R, Kullander K, Martin JH (2014). EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. J Neurosci 34(15): 5211-5221

Klein R* and Kania A* (2014). Ephrin signalling in the developing nervous system (invited review). Curr Opin Neurobiol 27: 16-24 * corresponding authors

Mishra A, Traut MH, Becker L, Klopstock T, Stein V*, Klein R* (2014). Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain. J Neurosci 34(12): 4187-99 * corresponding authors

Leyva-Díaz E, del Toro D, José Menal M, Cambray S, Susín R, Tessier-Lavigne M, Klein R*, Egea J*, López-Bendito G* (2014). FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Current Biology 24(5): 494-508. doi: 10.1016/j.cub.2014.01.042 * equal contribution

Klein P, Müller-Rischart AK, Motori E, Schönbauer C, Schnorrer F, Winklhofer KF, Klein R (2014). Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J 33 (4): 341-55, doi: 10.1002/embj.201284290

Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R (2014). The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol 204(3): 409-22, doi: 10.1083/jcb.201305037


Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams RH, Klein R, Lie DD, Jossin Y, Vanderhaeghen P (2013). Ephrin-b1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron 79(6): 1123-35

Paixao S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R (2013). EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80: 1407-1420

Seiradake E, Schaupp A, Del Toro Ruiz D, Kaufmann R, Mitakidis M, Harlos K, Aricescu AR, Klein R*, Jones EY* (2013). Structurally ecoded intraclass differences in EphA clusters drive distinct cell responses. Nat Struct Mol Biol 20(8): 958-64, doi: 10.1038/nsmb.2617 * corresponding authors

Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R (2013). Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci 33(12): 5399-410, doi: 10.1523/j.neurosci.4707-12.2013

Dudanova I, Klein R (2013). Integration of guidance cues: parallel signaling and crosstalk. Trends Neurosci 36(5): 295-304, doi: 10.1016/j.tins.2013.01.007

Filosa A, Klein R (2013). Ephrins and Eph receptors – Synaptogenesis (Book chapter). Comprehensive Developmental Neuroscience edited by Pasko Rakic and John Rubenstein (Editor-in-Chiefs). Elsevier 2: 659-670


Klein R (2012). Eph/ephrin signaling during development. ‘Development at a glance’ Review article and poster. Development 139: 4105–4109

Fontana X, Hristova M, Da Costa C, Patodia S, Thei L, Makwana M, Spencer-Dene B, Latouche M, Mirsky R, Jessen KR, Klein R, Raivich G, Behrens A (2012). c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling. JCB 198(1): 127–141

Dudanova I, Kao TJ, Herrmann JE, Zheng B, Kania A, Klein R (2012). Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance. J Neurosci 32(15): 5209 –5215


Dudanova I, Klein R (2011). The Axon’s Balancing Act: cis- and trans-Interactions between Ephs and Ephrins. Invited Preview. Neuron, doi: 10.1016/j.neuron.2011.06.030

Yamagishi S*, Hampel F*, Hata K, del Toro D, Schwark M, Kvachnina E, Bastmeyer M, Yamashita T, Tarabykin V, Klein, R#, Egea J# (2011). FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J, doi:10.1038/emboj.2011.189 * Equal contribution, # Corresponding authors

Hübener M, Klein R (2011). Elektrisch aktiv – Funktion und Entwicklung des Gehirns. In: Zukunft Gehirn. Eds: T Bonhoeffer, P Gruss. C.H. Beck, pp 12-36

Wang L, Klein R, Zheng B, Marquardt T (2011). Anatomical Coupling of Sensory and Motor Nerve Trajectory via Axon Tracking. Neuron, doi: 10.1016/j.neuron.2011.06.021

Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, Le W (2011). Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci, Sep 7; 31(36):12802-12815

Zhai J, Zhou W, Li J, Hayworth CR, Zhang L, Misawa H, Klein R, Scherer SS, Balice-Gordon RJ, Kalb RG (2011). The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease. Hum Mol Genet, doi: 10.1093/hmg/ddr335


Dudanova I, Gatto G, Klein R (2010). GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Curr Biol 20(23), 7 December 2010, pp 2150-2156

Aron L Klein R (2010). Repairing the Parkinsonian brain with neurotrophic factors. Review. Trends Neurosci, doi:10.1016/j.tins.2010.11.001

Klein R (2010). Cell Sorting during Regenerative Tissue Formation. Invited Preview. Cell 143, doi:10.1016/j.cell.2010.09.018

Griciuc A, Aron L, Roux MJ, KLein R, Giangrande A, Ueffing M (20101) Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila. PLoS Genet 6(8): e100107

Bashaw GJ, Klein R (2010) Signaling from Axon Guidance Receptors. Cold Spring Harb Perspect Biol 2010, May 1; 2(5): a001941 originally published online March 24, 2010

Aron L, Klein P, Pham TT, Kramer ER, Wurst W, Klein R (2010). Pro-survival role for Parkinson’s associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol 8: e1000349, doi:10.1371/j.pbio.1000349

Klein R (2010). Topography in hippocampal mossy fiber plasticity. Invited Preview. Neuron, doi:10.1016/j.neuron.2010.02.023

Paixão S and Klein R. (2010). Neuron-astrocyte communication and synaptic plasticity. Invited Review. Curr Opin Neurobiol 2010, 20: 1-8


Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, Diella F, Altick A, von Bartheld C, Klein R, Sendtner M, Unsicker K (2009). Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci 29: 13640-13648

Filosa A*, Paixão S*#, Honsek SD, Carmona MA, Becker L, Feddersen B, Gaitanos L, Rudhard Y, Schoepfer R, Klopstock T, Kullander K, Rose CR, Pasquale EB, Klein R# (2009). Neuron-glia communication via EphA4/ephrinA3 modulates LTP through glial glutamate transport. Nat Neurosci, 6 Sept [Epub ahead of print] 12: 1285-92, doi:10.1038/nn.2394
*Equal contribution; # corresponding authors

Klein R. (2009) Bi-directional modulation of synaptic functions by Eph/ephrin signaling. (Review). Nat Neurosci 12: 15-20. Epub 2008 Nov 23


Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Heß M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bösl MR, Fässler R, Lickert H, Klein R (2008). Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev 22: 3349-3362

Mishra A, Knerr B, Paixão S, Kramer E, Klein R (2008). Dendrite arborization and synapse maturation (Dasm)-1 is dispensable for dendrite arborization. Mol Cell Biol 28: 2782-2791

Wilkinson AG, Schittny JC, Reinhardt DP, Klein R (2008). A role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn 237: 2220-2234

Deininger K, Eder M, Kramer ER, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R (2008). The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci USA 105: 12539-12544. Epub 2008 Aug 22

Essmann CL, Martinez E, Geiger JC, Zimmer M, Traut MH, Stein V,  Klein R, Acker-Palmer A (2008). Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nat Neurosci 11(9): 1035-43, Aug 10 [Epub ahead of print].


Kowsky S*, Pöppelmeyer C*, Kramer ER*, Falkenburger BH, Kruse A, Klein R, Schulz JB.(2007). RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proc Natl Acad Sci USA 104: 20049-20054
* equal contribution

Kramer ER, Aron L, Ramakers GMJ, Seitz S, Zhuang X, Beyer K, Smidt MP, Klein R (2007). Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLOS Biol 5(3), doi:10.1371/journal.pbio.0050039

Egea J, Klein R (2007). Bi-directional Eph/ephrin signaling during axon guidance. Trends Cell Biol 17: 230-238

Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, Varoqueaux F, Deininger K, Schnütgen F, Brose N, Klein R, Kullander K, Betz A (2007). EphA4-dependent axon guidance is mediated by the RacGAP α2-chimaerin. Neuron 55: 756-767

Bouzioukh F, Wilkinson GA, Adelmann G, Frotscher M, Stein V, Klein R (2007). Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation, but not long-term depression. J Neurosci 27: 11279-88


Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R, Nebreda AR (2006). TEF-1 and C/EBP{beta} are major p38{alpha} MAP kinase-regulated transcription factors in proliferating cardiomyotes. Biochem J 396: 163-72

Kramer ER, Knott L, Su F, Dessaud E, Krull CE, Helmbacher F, Klein R (2006). Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron 50: 35-47

Ferby I, Reschke M, Kudlacek O, Knyazev P, Pantè G, Amann K, Sommergruber W, Kraut N, Ullrich A, Fässler R, Klein R (2006). Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12(5): 568-573

Kadison SR, Mäkinen T, Klein R, Henkemeyer M, Kaprelian Z (2006). EphB Receptors and ephrin-B3 Regulate Axon Guidance at the Ventral Midline of the Embryonic Mouse Spinal Cord. J Neurosci 26(35): 8909-14

Dufour A, Egea J, Kullander K, Klein R, Vanderhaeghen P (2006). Genetic Analysis of EphA-dependent Signalling Mechanisms Controlling Topographic Mapping in Vivo. Dev 133(22): 4415-20

Krysko O, Hulshagen L, Janssen A, Schütz G, Klein R, De Bruycker M, Espeel M, Gressens P, Baes M (2006). Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver. J Neurosci, Oct. 30 (Epub ahead of print)

Angrand PO, Segura I, Völkel P, Ghidelli S, Terry R, Brajenovic M, Vintersten K, Klein R, Superti-Furga G, Drewes G, Kuster B, Bouwmeester T, Acker-Palmer A (2006). Transgenic mouse proteomics identifies new 14-3-3 associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics 5(12): 2211-2227

Lauterbach J, Klein R (2006). Release of full-length EphB2 receptors from hippocampal neurons to co-cultured glial cells. J Neurosci 26(45): 11575-81


Diehl S, Bruno R, Wilkinson GA , Loose DA, Wilting J, Schweigerer L, Klein R (2005). Expression patterns of ephrinB2 and EphB2 in congenital venous malformations and normal umbilical vessels. Pediatr Res 57(4): 537-44

Mäkinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R*, Wilkinson GA (2005). PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 19: 397-410 *Corresponding author

Klein R (2005). Preview. Axon Guidance: Opposing EPHects in the Growth Cone. Cell 121(1): 4-6

Klein R. Ephrins (version 2.0) (4198) - Encyclopedia of Life Sciences.

Pante G, Thompson J , Lamballe F , Iwata T, Ferby I , Barr FA , Davies AM , Maina F, Klein R (2005). Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. In: J Cell Biol 171(2): 337-348

Egea J, Nissen UV , Dufour A , Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R (2005). Regulation of EphA4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron 47(4): 515-528


Thuret, S, Alavian, KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP , Klein R, Dyck RH, Simon HH (2004). The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem 91(6): 1302-1311

Anton ES, Ghashghaei  T , Weber JL, McCann C, Fischer TM, Cheung ID, Gassmann M, Messing A, Klein R, Schwab M H, Lloyd KCK, Lai C (2004). Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci 7(12): 1319-1328

Klein, R (2004). Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr Opin Cell Biol 16(5): 580-589 

Yang XD, Klein R, Tian XL , Cheng HT, Kopan R, Shen J (2004). Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 269(1): 81-94

Brockschnieder D, Lappe-Siefke C, Goebbels S, Boesl MR (2004). Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol 24(17): 7636-7642

Sock E, Rettig SD, Endrich J, Boesl MR, Tamm ER, Wegner M (2004). Gene targeting reveals an widespread role for the high-mobility group transcription factor Sox 11 in tissue remodeling. Mol Cell Biol 24(15): 6635-6644

Bruhl T, Urbich C, Aicher D, Acker-Palmer A, Zeiher AM, Dimmeler S (2004). Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. Circ Res 94(6): 743-751

Grunwald IC*, Korte M*, Adelmann G, Plueck A, Kullander K, Adams R, Frotscher M, Bonhoeffer T#, Klein R# (2004). Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci 7: 33-40 * and # equal contribution.


Zörner B, Wolfer DP , Brandis D, Kretz O, Zacher C, Madani R, Grunwald IC, Lipp HP, Klein R, Henn FA, Gass P (2003). Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”. Biol Psychiatry 54: 972-982

Tavosanis G, Gonzalez C (2003). gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila. Proc Natl Acad Sci USA 100 18: 10263-10268

Helmbacher F, Dessaud E, Arber S, deLapeyriere O, Henderson C, Klein R, Maina F (2003). Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools. Neuron 39(5): 767-777

Compagni A, Logan M, Klein R, Adams RH (2003). Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell 5: 217-230

Kullander K, Butt SJB, Lebert JM, Lundfald L, Restrepo CE, Rydström A, Klein R*, Kiehn O* (2003). Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking. Science 299: 1889-1892 * Equal contribution.

Palmer A, Klein R (2003). Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Genes Dev 17: 1429-1450, Review


Klein R (2002). Novel effector function for an old receptor. News & Views. Nat Cell Biol, 4: E11-E12

Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL (2002). Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J. Biol Chem 277: 3606-3613

Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R*, Minichiello, L* (2002). Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev 16: 633-645.*Corresponding authors

Grunwald I, Klein R, (2002). Axon guidance: Receptor complexes and signaling mechanisms. Curr Opin Neurobiol 12: 250-259, Review

Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R (2002). EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell 9: 725-737

Kullander K, Klein R (2002). Mechanisms and functions of Eph and Ephrin signaling. Nat Rev Mol Cell Biol 3: 475-486, Review

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng Francis J, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC (2002). Discoidin Domain Receptor 2 (DDR2) interacts with Src and Shc following its activation by Type I collagen. J Biol Chem 277: 19206-19212

Zhang SQ, Tsiaras B, Araki T, Wen G, Minichiello L, Klein R, Neel BG (2002). Receptor-specific regulation of PI3K activation by the protein-tyrosine phosphatase Shp2. Mol Cell Biol 22: 4062-4072

Vyssotski AL, Dell’Omo G, Poletaeva II, Vyssotski, DL, Minichiello L, Klein R, Wolfer DP, Lipp HP (2002). Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility. Hippocampus 12: 27-38

He XP, Minichiello L, Klein R, McNamara JO (2002). Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. J Neurosci 22: 7502-7508

Klein R (2002). Book Chapter: Eph receptors. Handbook of Cell Signaling. Eds: R Bradshaw, E Dennis, Academic Press

Minichiello L*, Calella AM, Medina DL, Bonhoeffer T, Klein R*, Korte M (2002). Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron 36: 121-137 * Corresponding authors


Adams R, Klein R (2001). Eph receptors and ephrin ligands: essential mediators of vascular development. Trends Cardiovasc Med (TCM) 10: 183-188, Review

Maina F, Pante G, Helmbacher F, Andres R, Porthin A, Davies AM, Ponzetto C, Klein R (2001). Coupling Met to specific pathways results in distinct developmental outcomes. Mol Cell 7: 1293-1306

Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R (2001). The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104: 57-69

Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Manes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martinez-A C, Klein R (2001). The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep 2: 446-452

Kullander K, Mather NK, Diella F, Dottori M, Boyd AW, Klein R (2001). Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron 29: 73-84

Klein R (2001). Excitatory Eph receptors and adhesive ephrin ligands. Review. Curr Opin Cell Biol 13: 196-203

Kullander K, Croll SD, Zimmer M, Pan L, McClain J, Hughes V, Zabski S, DeChiara TM, Klein R, Yancopoulos GD, Gale N W(2001). EphrinB3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev 15: 877-888

Grunwald I, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R (2001). Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32: 1027-1040

Reviewed in "Science's Compass - Prespectives" by Ghosh, A (2002). Learning more about NMDA receptor regulation. Science, 295: 449-451. Reviewed in: Murai KM, Pasquale EB (2002). Can Eph receptors stimulate the mind? Neuron 33: 159-162

Graus-Porta D, Blaess S, Senften M, Littlewood-Evans A, Damsky C, Huang Z, Orban P, Klein R, Schittny JC, Mueller U (2001). b1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31: 376-379


Fan G, Egles C, Sun Y, Minichiello L, Renger JJ, Klein R, Liu G, Jaenisch R (2000). Knocking NT4 into the BDNF gene locus not only rescues BDNF deficient mice but also reveals their distinct activities in vivo. Nat Neurosci 3: 350-357

Bruening JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Mueller-Wieland D, Kahn CR (2000). Role of brain insulin receptor in control of body weight and reproduction. Science 289: 2122-2125

Korte M, Minichiello L, Klein R, Bonhoeffer T (2000). Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation. Neuropharmacology 39: 717-724

Caton A, Hacker A, Naeem A, Livet J, Maina F, Bladt F, Klein R, Birchmeier C, Guthrie S (2000). The branchial arches and HGF are growth-promoting and chemoattractive for cranial motor axons. Development 127: 1751-1760

Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR (2000). Essential role of p38a MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6: 109-116


Klein R (November 1999). Ephrins, in Embryonic Encyclopedia of Life Sciences Nature Publishing Group, London,

Brueckner K, Labrador, JP, Scheifferle P, Herb A, Seeburg PH, Klein R (1999). EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22: 511-524

Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R (1999). Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis and sprouting angiogenesis. Genes Dev 13: 295-306

Plueck-Becklas AR, Klein R (1999). Tiermodelle (invited book chapter, german). Molekulare Medizin. Grundlagen, Pathomechanismen, Krankheitsbilder. Eds: MW Hentze, AE Kulozik, CR Bartram, Walter De Gruyter, Berlin

Holder N, Klein R (1999). Eph receptors and ephrins: effectors of morphogenesis (Review). Development 126: 2033-2044

Maina F, Klein R (1999). Hepatocyte growth factor - a versatile signal for developing neurons (Review). Nat Neurosci 2: 213-217

Lu Q, Gore M, Zhang Q, Camenisch T, Boast S, Casagranda F, Lai C, Skinner MK, Klein R, Matsushima GK, Earp HS, Goff SP, Lemke G (1999). Tyro 3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728

Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schuetz G (1999). Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103

Minichiello L, Korte M, Wolfer D, Kuehn R, Unsicker K, Cestari V, Rossi-Arnaud C, Lipp HP, Bonhoeffer T, Klein R (1999). Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24: 401-414

Klein R (1999). Bi-directional signals establish boundaries (Dispatch). Curr Biol 9: R691-694

Maina F, Hilton MC, Andres R, Wyatt S, Klein R, Davies AM (1998). Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron 20: 835-846

Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R, Flanagan JG (1998). Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene 16: 471-480

Schober A, Wolf N, Huber K, Hertel R, Krieglstein K, Minichiello L, Kahane N, Widenfalk J, Kalcheim C, Olson L, Klein R, Lewin GR, Unsicker K (1998). TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla. J Neurosci 18: 7272-7284

Minichiello L, Casagranda F, Soler Tatche R, Stucky CL, Postigo A, Lewin GR, Davies AM, Klein R (1998). Mutation in trkB causing loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron 21: 335-345

Brueckner K, Klein R (1998). Ephrin and Eph receptor signaling (Review). Curr Opin Neurobiol 8: 375-382

Schober A, Minichiello L, Keller M, Huber K, Layer PG, Roig-Lopez JE, Garcia-Arraras JE, Klein R, Unsicker K (1997). Reduced AChE activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-, but not TrkB-deficient mice. J Neurosci 17: 891-903

Brueckner K, Pasquale EB, Klein R (1997). Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 275: 1640-1642

Labrador JP, Brambilla R, Klein R (1997). The amino-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signalling. EMBO J 16: 3889-3897

Schimmang T, Alvarez-Bolado G, Minichiello L, Vazquez E, Giraldez F, Klein R, Represa J (1997). Survival of inner ear sensory neurons in trk mutant mice. Mech Dev 64: 77-85

Brambilla R, Gnesutta N, Minichiello L, White G, Roylance A, Herron C, Ramsey M, Wolfer DP, Cestari V, Rossi-Arnaud C, Grant SGN, Chapman PF, Lipp HP, Sturani E, Klein R (1997). A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390: 281-286

Maina F, Hilton MC, Ponzetto C, Davies AM, Klein R (1997). Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons. Genes Dev 11: 3341-3350

Orioli D, Klein R (1997). The Eph receptor family: axonal guidance by contact repulsion. Review. Trends Genet 13: 354-359

Klein R, Bandtlow C (1997). Neurotrophe Faktoren. In: Klinische Neurobiologie, Eds:  T Herdegen, M Baehr, T Toelle,  Spektrum Akademischer Verlag, Heidelberg, Germany, pp 39-59

Pinon L, Minichiello L, Klein R, Davies AM (1996). Timing of neuronal death in trkA, trkB, and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling. Development 122: 3255-3261

Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T (1996). Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J 15: 6035-6049

Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R (1996). Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell 86: 35-46

Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R, Ponzetto C (1996). Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87: 531-542

Minichiello L, Klein R (1996). TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. Genes Dev 10: 2849-2858

Pasquale EB, Matthews W, Klein R (1996). LERK2 and LERK5/HTK-L. Human Cytokines: Handbook for Basic and Clinical Research, Volume III. Eds: BB Aggarwal, JU Gutterman, Blackwell Science

Brambilla R, Brueckner K, Orioli D, Bergemann AD, Flanagan JG, Klein R (1996). Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol Cell Neurosci 8: 199-209

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