Publications
2012
Bruder J, Siewert K, Obermeier B, Malotka J, Scheinert P, Kellermann J, Ueda T, Hohlfeld R, Dornmair K (2012) Target specificity of an autoreactive gd-T cell receptor in myositis. J. Biol. Chem. doi/10.1074/jbc.M112.356709.
Kim SM, Bhonsle L, Besgen P, Nickel J, Vollmer S, Backes A, Held K, Vollmer S, Dornmair K, Prinz JC (2012) Analysis of the paired TCR alpha- and beta-chains of single human T cells. PLoS ONE (in press)
Wekerle H, Flügel A, Fugger L, Schett G, Serreze DV (2012) Autoimmunity's next top models. Nature Medicine, 18: 66-70
Mayer CM, Meinl E (2012) Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Therapeutic Advances in Neurological Disorders (in press)
Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada L, Medico E, Hohlfeld R, Meinl E, Farina C (2012) Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med, 209: 521-535
Eisele S, Krumbholz M, Fischer MT, Mohan H, Junker A, Arzberger T, Hohlfeld R, Bradl M, Lassmann H, Meinl E (2011) Prospects of transcript profiling for mRNAs and micro RNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathol (in press)
Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K (2011) Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nature Medicine, 18: 824-829
Lippok S, Seidel SA, Duhr S, Uhland K, Holthoff HP, Jenne D, Braun D (2012) Direct Detection of Antibody Concentration and Affinity in Human Serum using Microscale Thermophoresis. Anal Chem, Mar 7. [Epub ahead of print]
Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE (2012) NSP4, a novel elastase-related protease in human neutrophils with arginine specificity. Proc Natl Acad Sci, (in press)
Mankan AK, Dau T, Jenne D, Hornung V (2012) The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils. Eur J Immunol (in press)
Hedberg V, Melberg A, Kuhl A, Jenne D, Oldfors, A (2012) Autosomal dominant myofibrillar myopathy with ARVC7 is caused by a DES mutation. Eur J Hum Gen (in press)
2011
Berer K, Mues M, Koutroulos M, Al Rasbi Z, Boziki M, Johner C, Wekerle H, Krishnamoorthy G (2011) Commensal microbiota and myelin autoantigen cooperate to trigger T/B cell mediated spontaneous EAE, a model for relapsing-remitting multiple sclerosis. Nature 479:538-541
Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T (2011) Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J Virol. 85(19):9680-5
Pellkofer HL, Krumbholz M, Berthele A, Hemmer B, Gerdes LA, Havla J, Bittner R, Canis M, Meinl E, Hohlfeld R, Kuempfel T (2011) Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurolog 76(15):1310-5
Ivanidze J, Hoffmann R, Lochmüller H, Engel AG, Hohlfeld, R*, Dornmair K* (2011) Inclusion Body Myositis: Laser microdissection reveals differential upregulation of IFN gamma signaling cascade in attacked versus non-attacked myofibers. Am. J. Pathol. 179:1347-1359
Junker A, Hohlfeld R, Meinl E (2011) The emerging role of microRNAs in multiple sclerosis. Nat Rev Neurol 7: 56-59
Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B*, Bar-Or A*, Meinl E*, Derfuss T* (2011) Antobodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77(6):580-8, * equal contribution
Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T (2011) Expression of HSV-1 encoded miRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J. Virol. doi:10.1128/JVI.00874-11
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM (2011). Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology 140(4):1272-82
Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW (2011). Neurotophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunol. 186(2):1131-9
Fitzner D, Schnaars M, van Rossum D, Krishnamoorthy G, Dibaj P, Bakhti M, Regen T, Hanisch UK, Simons M (2011) Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci 124:447-458
Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K (2011) Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J. Neuroimmunol. 233:245-248
Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A (2011) Highly skewed T- cell receptor V beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia Blood Cancer Journal 1, doi:10.1038/bcj.2011.6.
Berer K, Wekerle H, Krishnamoorthy G (2011) B cells in spontaneous autoimmune diseases of the central nervous system. Mol Immunol 48:1332-1337
Kessenbrock K, Dau T, Jenne DE (2011) Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med 89:23-28
Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard WI, Li H, Holsboer F, Turck CW, Touma, C (2011) Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res 220:305-311
2010
Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G (2010) Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. PLOS ONE 5(11): e15531
Silva F, Hummel AM, Jenne DE, Specks U (2010) Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's, J Autoimmun. 35(4):299-308
Kessenbrock K, Dau T, Jenne DE (2010) Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response, J Mol Med. 89(1):23-8
Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (2010) Neutrophil elastase, proteinase 3 and cathepsin G as therapeutic targets in human diseases, Pharmacol Reviews 62(4):726-59
Kawakami N, Flügel A (2010). Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Semin Immunopathol. 32: 275-287
Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A (2010). Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133: 1930-1943
Kurschus FC, Jenne DE (2010) Delivery and therapeutic potential of human Granzyme B. Immunological Rev. 235:159-171
Kuhl A, Korkmaz B, Utecht B, Kniepert A, Schönermarck U, Specks U, Jenne DE (2010) Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener’s granulomatosis. J. Immunology, 185: 387-399
Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E (2010) Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are up-regulated and associated with infiltrating immune cells. Brain Pathol., 20: 966-975
Wekerle H and Hohlfeld R (2010) Molecular oracles for multiple sclerosis therapy. Nature Medicine 16(4):376-377
Wekerle H and Hohlfeld R (2010) Zero tolerance (to AChR) and ways to overcome it. Ann Neurol 67(4):422-424
2009
Dornmair K, Meinl E, Hohlfeld R (2009) Novel approaches for identifying target antigens of autoreactive human B and T cells. Seminars in Immunopathology 31:467-477
Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, Lassmann H, Wekerle H, Hohlfeld R, Meinl E (2009) MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47, Brain 132:3342-3352
Bartholomäus I*, Kawakami N*, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, Klinkert WEF, Flügel-Koch C, Issekutz TB, Wekerle H, Flügel A (2009) Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions, Nature Nov 5, 462(7269):94-98, * Co-first authors
Krishnamoorthy G, Saxena A, Mars LT, Domingues H.S, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau R, Wekerle H (2009) Myelin specific T cells co-recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nature Medicine 15(6):626-632
Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nature Medicine 15(6):623-625
Pöllinger B, Krishnamoorthy G, Berer K, Lassmann H, Bösl M, Dunn R, Domingues HS, Holz A, Kurschus FC, Wekerle H (2009) Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit MOG-specific endogenous B cells. J Exp Med 206(6):1303-1316
Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Flügel A, Dockery P, O’Brie T, Howard L, Windebank AJ, Barry FP (2009) Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without diff erentiating into neural cells. Tissue Eng Part A 15(10):3049-59
Schwab N, Bien CG, Waschbisch A, Becker A, Vince, GH, Dornmair K, Wiendl H (2009) CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132:1236-1246
Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K (2009) Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol 66(5):655-658
Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C, Meinl E (2009)
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci USA 106:8302-8307
Kurschus F, Paramita Pal P, Bäumler P, Jenne DE, Wiltschi B, Budisa N (2009) Gold fluorescent annexin A5 as a novel apoptosis detection tool. Cytometry, 75A: 626-633
Romero V, Fellows E, Jenne DE, Andrade F (2009) Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death Differ 16(2):340-348
Hohlfeld R (2009) Multiple sclerosis: Human model for EAE? Eur J Immunol. 39(8):2036-2039
Krishnamoorthy G, Wekerle H (2009) EAE: An immunologist’s Magic Eye. Eur J Immunol 39(8): 2031-2035
Kerschensteiner M, Meinl E, Hohlfeld R (2009) Neuro-immune crosstalk in CNS diseases. Neuroscience 158(3):1122-1132
2008
Korkmaz B, Kuhl A, Bayat B, Santoso S, Jenne DE (2008) A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. J Biol Chem 283(51): 5976-82. Epub 2008 Oct 14
Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, Lottspeich F, Hohlfeld R, Dornmair K (2008) Matching of oligoclonal Ig transcripts and proteins of cerebrospinal fluid in multiple sclerosis. Nat Med 14: 688-693
Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE (2008) Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest 118(7): 2438-47
Kurschus FC, Fellows E, Stegmann E, Jenne DE (2008) Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate dependent endocytosis. Proc Natl Acad Sci USA 105:13799-13804
Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne DE, Holak TA, Werb Z, Sixt M, Wedlich-Söldner R (2008) Lifeact: a versatile marker to visualize F-actin. Nature Methods 5(7):605-7
Deininger K, Eder M, Kramer E, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R (2008) The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci USA 105:12539-12544
Krumbholz M*, Faber H*, Steinmeyer F, Hoffmann LA, Kümpfel T, Pellkofer H, Derfuss T, Ionescu C, Starck M, Hafner C, Hohlfeld R, Meinl E (2008) Interferon-ß increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 131: 1455-1463. * equal contribution
Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM (2008) CD28 superagonistic antibodies elicit two functionally distinct waves of T cell activation. J Clin Invest 118(4):1405-1416
Matheu MP, Beeton C, Garcia A, Uemura MI, Li D, Pal S, de la Maza LM, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD (2008) In situ imaging of effector/memory. T cells during DTH and suppression by Kv1.3 channel block, Immunity 29: 602–614
Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E*, Farina C* (2008). BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. J Neuroimmunol 197: 128-139. *equal contribution
Obermeier B, Mentele R, Malotka J, Dornmair K (2008) Analysis of patient-specific immunoglobulin proteomes and transcriptomes by PCR cloning and mass spectrometry. Nat Protoc published online, doi: 10.1038/nprot.2008.87
Hohlfeld R, Meinl E, Dornmair K (2008) B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. J Neurol Sci 274(1-2): 5-8
Kuhl A, Melberg A, Meinl E, Nürnberg G, Nürnberg P, Kehrer-Sawatzki H, Jenne DE (2008) Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. Eur J Hum Genet 16 :367-373
Hohlfeld R (2008) Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis? J Neurol Sci 265: 93-96
Meinl E, Krumbholz M, Derfuss T, Junker A, Hohlfeld R (2008). Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosis. J Neurol Sci 274(1-2): 42-4
Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O’ Brien T, Howard L, Windebank AJ, Barry FB (2008) Gene-modified Mesenchymal Stem Cells Express Functionally Active Nerve Growth Factor on an Engineered Poly Lactic Glycolic Acid (PLGA) Substrate. Tissue Engineering Part A, 14(5):681-90
Krumbholz M, Meinl I, Kümpfel T, Hohlfeld R, Meinl E (2008) Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71: 1350-1354
Gruber A, Cannarile MA, Cheminay C, Ried C, Drexler I, Dornmair K, Marconi, P, Hoffmann R, Häcker G, Brocker T (2008) Independent regulation of CTL differentiation and apoptosis via Bim: a role for antigen-presenting parenchymal cells [Submitted]
Lahl K, Mayer C, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Buer J, Wagner H, Sparwasser T (2008) Development of non-functional regulatory T cells and defective control of Th2-cytokine production in natural scurfy mutant mice [Submitted]
Bradl M, Dornmair K, Hohlfeld R (2008). New tools for investigating the immunopathogenesis of MS: Principles and applications. In: Multiple Sclerosis: A Comprehensive Text (Raine CS, McFarland HF, Hohlfeld R eds). Saunders, Elsevier, Edinburgh. p 284-299
2007
Mathey EK*, Derfuss T*, Storch MK, Williams KR, Hales K, Woolley DR, Al-Hayani A, Davies SN, Rasband M, Velhin S, Olsson T, Moldenhauer A, Hohlfeld R, Meinl E*, Linington C* (2007) Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med 204: 2363-2372 (* contributed equally)
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007) Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell death program. Blood 110: 544-552
Odoardi F, Kawakami N, Klinkert WEF, Wekerle H, Flügel A (2007): Blood-born soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. PNAS 104: 18625-18630
Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WEF, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A (2007): Instant effect of soluble autoantigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. PNAS 16: 920-25
Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WEF, Straten PT, Kollgaard T, Sixt M, Brakebusch C (2007) RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood 109: 2346-2355
Jarius S, Eichhorn P, Albert MH, Wagenpfeil S, Wick M, Belohradsky BH, Hohlfeld R, Jenne DE, Voltz R (2007) Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNF alpha-dependent and Fc-receptor-independent way. Blood 109:4376-4382
Junker A*, Ivanidze J*, Malotka J, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K (2007). Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130: 2789-2799 (*equal contribution)
Junker A, Ivanidze J, Malotka J, Eiglmeier I, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K (2007) Multiple Sclerosis: T cell receptor expression in distinct brain regions. Brain 130: 2789-2799
Krishnamoorthy G, Holz A, Wekerle H (2007). Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 84: 1161-1173
Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl H (2007). Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Mol Cell Neurosci 36: 416-424
Grundtner R, Dornmair K, Dahm R, Flügel A, Kawakami N, Zeitelhofer M, Schoderboeck L, Nosov M, Selzer E, Willheim M, Kiebler M, Wekerle H, Lassmann H, Bradl M (2007) Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiol Dis 28: 261-275
Hohlfeld R, Dornmair K (2007). Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69: 1966-1967
Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus H-G, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D (2007). Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia. Brain Pathology 17: 389-398
Krumbholz M, Theil D, Steinmeyer F, Cepok S, Hemmer B, Hofbauer M, Farina C, Derfuss T, Junker A, Arzberger T, Sinicina I, Hartle C, Newcombe J, Hohlfeld R, Meinl, E (2007) CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol 190: 72-79
Flügel A, Odoardi F, Nosov M, Kawakami N (2007): Autoaggressive effector T cells in the course of Experimental Autoimmune Encephalomyelitis visualized in the light of two-photon microscopy. J Neuroimmunol 191: 86-97
Wekerle H, Flügel A (2007) Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis. In “Molecular Neurology” (S Waxman ed.) Elsevier, pp 475-497
Wekerle H, Kurschus FC (2007) Disease Models. Review in Drug Discov Today 3: 359-367
Farina C, Aloisi F, Meinl E (2007): Astrocytes are active players in cerebral innate immunity. Trends Immunol 28: 138-145
Hoffmann LA, Krumbholz M, Faber H, Kümpfel T, Starck M, Pöllmann W, Meinl E, Hohlfeld R (2007) Multiple Sclerosis: Relating MxA transcription to anti-interferon-beta neutralizing antibodies. Neurology, 68: 958-959
Hohlfeld R, Kerschensteiner M, Meinl E (2007) Dual role of inflammation in CNS disease. Neurology 68(22 Suppl 3):S58-S63
Jenne DE, Aries PM, Einwächter S, Akkad AD, Wieczorek S, Lamprecht P, Gross WL (2007) The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis. Annals of the Rheumatic Diseases 66:1266-1267
Krumbholz M, Pellkofer H, Gold R et al (2007) Delayed allergic reaction to natalizumab associated with early formation of neutralizing antibodies. Arch Neurol 64(9):1331-1333
Klatt J, Hartung HP, Hohlfeld R (2007) FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis. Nervenarzt 78(10):1200-1208
Weber MS, Hohlfeld R, Zamvil SS (2007) Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics 4(4):647-653
2006
Seitz S, Schneider CK, Malotka J, Nong X, Engel, AG, Wekerle H, Hohlfeld R, and Dornmair K (2006) Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of frozen human tissues. Proc.Natl.Acad.Sci.USA 103:12057-12062.
Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WEF, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A (2006) Instant effect of soluble autoantigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America, in press.
Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang L, Potter BVL, Guse AH (2006). Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. British Journal of Pharmacology 149(4): 337-44.
Krishnamoorthy G, Lassmann, H, Wekerle H, and Holz A (2006). Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest. 116:2385-2392
Meinl E, Krumbholz M, Hohlfeld R (2006). B lineage cells in the inflammatory CNS environment. Ann. Neurol. 59:880-892
Krumbholz M, Theil D, Cepok S, Hemmer B, Kivisakk P, Ransohoff R M, Hofbauer M, Farina C, Derfuss T, Hartle C, Newcombe J, Hohlfeld R, and Meinl E (2006). Chemokines in MS: CXCL12 and CXCL13 upregulation is differentially linked to CNS immune cell recruitment. BRAIN 129:200-211
2005
Flügel A, Kawakami N (2005): Immune processes in the light of Two-photon microscopy. In “Leukocyte Trafficking” (A Hamann, Engelhardt B eds.) Wiley-VCH, pp 472-496
Krumbholz M, Specks U, Wick M, Kalled S L, Jenne D, Meinl E (2005). BAFF is elevated in serum of patients with Wegener’s granulomatosis. J.Autoimm.25:298-302
Bade B, Boettcher HE, Lohrmann J, Hink-Schauer C, Bratke K, Jenne DE, Virchow J C, and Luttmann W (2005). Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. In: International Immunology 17(11): 1419-1428
Zagrebelsky M, Holz A, Dechant G, Barde Y A, Bonhoeffer T and Korte M (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. In: Journal of Neuroscience 25(43): 9989-9999.
Wiesner O, Litwiller RD, Hummel AM, Viss MA, McDonald CJ, Jenne DE, Fass DN and Specks U (2005). Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments. In: FEBS Letters 579(24): 5305-5312
Farina C, Weber MS, Meinl E, Wekerle H and Hohlfeld R (2005). Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. In: Lancet Neurology 4(9): 567-575. Review
Spiegel M, Oexle K, Horn D, Windt E, Buske A, Albrecht B, Prott EC, Seemanova E, Seidel J, Rosenbaum T, Jenne DE, Kehrer-Sawatzki HK and Tinschert S (2005). Childhood overgrowth in patients with common NF1 microdeletions. In: European Journal of Human Genetics 13(7): 883-888
Ziemssen T, Kümpfel T, Schneider H, Klinkert WEF, Neuhaus O and Hohlfeld R (2005). Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: Implications for multiple sclerosis therapy. In: Journal of the Neurological Sciences 233(1-2): 109-112. Review
Bradl M, Bauer J, Flügel A, Wekerle H and Lassmann H (2005). Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. In: American Journal of Pathology 166(5): 1441-1450
Derfuss T, Hohlfeld R and Meinl E (2005). Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell response. In: Journal of Neurology 252(8): 968-971
Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, and Flügel A (2005a). Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J. Exp. Med. 201(11): 1805-1814
Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu C-M, Kalled SL, Hess DM, Serafini S, Aloisi F, Wekerle H Hohlfeld R, Meinl E (2005). BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med.201(2):195-200
Kawakami N, Odoardi F, Ziemssen T, Bradl M, Ritter T, Neuhaus O, Lassmann H, Wekerle H, Flügel A (2005b). Autoimmune CD4+ T Cell Memory: Lifelong Persistence of Encephalitogenic T Cell Clones in Healthy Immune Repertoires. J Immunol. 175(1):69-81
Vargas-Leal V, Bruno R, Derfuss T, Krumbholz M, Hohlfeld R, Meinl E (2005). Expression and function of glial cell line-derived neurotrophic factor (GDNF) family ligands and their receptors on human immune cells. The Journal of Immunology 175:2301-2308.
Kurschus FC, Bruno R, Fellows E, Falk CS, Jenne DE (2005). Membrane receptors are not required to deliver granzyme B during killer cell attack. Blood. 105(5):2049-58
Schmid C, Diem H, Herrman K, Voltz R, Ott G and Hallek M (2005) Central neurogenic hyperventilation as complication of Richter's syndrome. Journal of Clinical Oncology. 23(9): 2096-2098
Wiendl H, Hohlfeld R, and Kieseier BC (2005). Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends in Immunology. (accepted)
Jenne DE, Kley RA, Vorgerd M, Schröder JM, Weis J, Reimann H, Albrecht B, Nürnberg P, Thiele H, Müller CR, Meng G, Witt C, Labeit S (2005). Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3. Biol. Chem. 386:61-67
Theil D , Farina C, Meinl E (2005). Differential expression of CD150 (SLAM) on monocytes and macrophages in chronic inflammatory contexts: Abundant in Crohn’s disease, but not in multiple sclerosis. J.Clin.Pathol. 58:110-111
Wekerle H (2005). Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proc. Natl. Acad. Sci. USA 102. (Editorial). Review
Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, Meinl E (2005). Preferential expression and function of Toll-like Receptor 3 in human astrocytes. J. Neuroimmunol. 159(1-2):12-19
2004
Kawakami, N., S. Lassmann, Z. X. Li, F. Odoardi, T. Ritter, T. Ziemssen, W. E. F. Klinkert, J. W. Ellwart, M. Bradl, K. Krivacic, H. Lassmann, R. M. Ransohoff, H. D. Volk, H. Wekerle, C. Linington and A. Flügel (2004) The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. Journal of Experimental Medicine 199, 2: 185-197
Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R and Goebels N (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proceedings of the National Academy of Sciences of the United States of America 101, 8: 2428-2433
Weber, M.S., M. Starck, S. Wagenpfeil, E. Meinl, R. Hohlfeld and C. Farina (2004) Glatiramer Acetate inhibits monocyte reactivity in vitro and in vivo. Brain 127: 1370-1378
Pfister H, Ollert M, Fröhlich L O, Quintanilla-Fend L, Colby T V, Specks U, Jenne, D E (2004) Autoantibodies against the murine homolog of Wegener’s autoantigen (proteinase 3) are pathogenic in vivo. Blood 104: 1411-1418
Kehrer-Sawatzki H, Kluwe L, Sandig C, Kohn M, Wimmer K, Krammer U, Peyrl A, Jenne D E, Hansmann I, Mautner V-F (2004) High frequency of mosaicism among NF1 patients with large deletions in 17q11.2 caused by somatic recombination of the JJAZ1 gene. Am. J. Hum. Genet. 75: 410-423
Pellkofer H, Schubart AS, Höftberger R, Schutze N, Pagany M,Schüller M, Lassmann H, Hohlfeld R, Voltz R and Linington C (2004). Modeling paraneoplastic disease: Onconeuronal antigen specific T cells mediate autoimmune encephalomyelitis in the rat. Brain 127: 1822-1830
Linke R,Schröder M , Helmberger T and Voltz R (2004) Antibody-positive paraneoplastic neuroligical syndromes: The value of CT and FDG-PET imaging for tumor diagnosis. Neurology 63, 2: 282-286
Wiesner O, Russell KA , Lee AS, Jenne DE , Trimarchi M, Gregorini G and Specks U : Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase: a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Arthritis Rheumatism 50(9):2954-2965, 2004
Mead R J, Neal JW, Griffiths M R, Linington C , Botto M, Lassmann H and Morgan BP (2004) Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Laboratory Investigation 84, 1: 21-28.
Scheid R, Lincke T, Voltz R and Cramon von DY(2004). Serial FDG-PET and MR-imaging of paraneoplastic limbic encephalitis. Archives of Neurology 61(11):1785-1789
Kurschus FC, Kleinschmidt M, Fellows E, Dornmair K, Rudolph R, Lilie H, Jenne DE (2004). Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett. 562(1-3):87-92
Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H and Hohlfeld R (2004). Fast dissociation kinetics of an autoreactive human Vγ1.3Vδ2 T-cell receptor/antigen complex. Journal of Neuroimmunology 152: 168-175
Farina C, Theil D, Semlinger B, Hohlfeld R and Meinl E (2004) Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines. International Immunology 16: 799-809
Flügel A (2004) Gentransfer in Antigen-spezifischen CD4+ T-Zellen: Schicksal und Funktion autoreaktiver T-Zellen im Organismus. Ludwig-Maximilians-Universität, München.
Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J , Sillevis Smitt P, Vedeler C,Verschuuren JJGM, Vincent A and Voltz R (2004) For the Paraneoplastic Neurological Syndrome Euronetwork. Recommended diagnostic criteria for paraneoplastic neurological syndromes. Journal of Neurology, Neurosurgery and Psychiatry 75, 8: 1135-1140
Karrasch T, Weil M, Voltz R, Schulz C, Audebert F, Woenckhaus M, Hofstadter F , Bogdahn U, Schölmerich J, Schaffler A and Steinbrecher A (2004) "Fußkribbeln", Vergesslichkeit und progrediente Wesensveränderung bei einer 63-jährigen Patientin. Internist 45,3: 341-346
Moser CM, Jenne DE, Pfister H, Ollert M and Krombach F (2004) Leukocyte migration in proteinase-3/elastase-2 double mutant mice in vivo. Journal of Vascular Research 41, 1: 94-95
Vargas V: Expression and function of GDNF family ligands and their receptors by human immune cells. Ludwig-Maximilians-Universität, München (2004-04-02)
Voltz R, Starck M, Zingler V, Strupp M and Kolb HJ(2004) Mitoxantrone therapy in multiple sclerosis and acute leukaemia: A case report out of 644 treated patients. Multiple Sclerosis 10: 472-474
Hohlfeld R and Wekerle H (2004). Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines (Review) Proc. Natl. Acad. Sci. USA 101 (Suppl. 2), 14599-14606.
Ziemssen T (2004) Neuroprotection and glatiramer acetate: The possible role in the treatment of Multiple Sclerosis. Frontiers in Clinical Neuroscience: Neurodegeneration and Neuroprotection 541: 111-134
Hohlfeld R (2004) Immunologic factors in primary progressive multiple sclerosis. (Review). Multiple Sclerosis 10: S16-S22
Jenne DE (2004) Peutz-Jeghers Syndrome. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (edited by K. Ruckpaul and Detlev Ganten) Springer Verlag.
Meinl, E. and R. Voltz (2004) Biomarker in der Therapie der Multiplen Sklerose: Läßt sich der Erfolg bald vorhersagen? MMW-Fortschr. Med. Sonderheft 2: 57-58.
2003
Hink-Schauer C, Estébanez-Perpiñá EE, Kurschus FC, Bode W, Jenne DE (2003) Crystal structure of the apoptosis-inducing human granzyme A dimer. Nature Struct. Biol. 10: 535-540.
Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N (2003) Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc Natl Acad Sci USA 100(7): 4090-4095.
Wiendl H, Mitsdoerffer M, HofmeisterV, Wischhusen J, Weiss EH, Dichgans J, Lochmüller H, Hohlfeld R, Melms A, Weller M (2003). The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy. Brain 126: 176-185
Theil D, Derfuss T, Paripovic I, Meinl E, Schueler O, Strupp M, Arbusow V, Brandt T (2003) Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response. Am J Pathol 163:2179-2184
Dornmair K, Weltzien HU, Goebels N, Wekerle H, and Hohlfeld R (2003). T-cell mediated autoimmunity: Novel techniques to characterize autoreactive T cell receptors. Am J Pathol 163:1215-1226.
Arbour N, Holz A, Sipe JC, Naniche D, Romine JS, Zyroff J, Oldstone MBA (2003) A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis. Journal of Neuroimmunology 137:197-209
Jenne DE, Tinschert S, Dorschner MO, Hameister H, Stephens K, Kehrer-Sawatzki H (2003). Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Genes, Chromosomes, Cancer 37: 111-120
Voltz R, Albrich W, Hohlfeld R, Nagel D, Wick M, Kirchner T, Sommer N, Illa I, Kaminski H, Schumm F (2003). Anti-titin antibodies are not associated with a specific thymoma histology. Journal of Neurology, Neurosurgery and Psychiatry 74:282 (Letter)
Wekerle H, Hohlfeld R. Molecular mimicry in multiple sclerosis (2003). New England Journal of Medicine 349: 185-186. (Editorial)
Hohlfeld R(2003) Hunting (auto)immune T cells in neuroimmunological diseases. Brain 126: 2-4 (Editorial)
Kerschensteiner M, Hohlfeld R (2003). Neurotrophic factors protect myelin from attack. International MS Journal, 10: 2-4 (Editorial)
Dalakas M, Hohlfeld R. Polymyositis and dermatomyositis (2003). Lancet 362: 971-982. (Review)
Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R (2003). Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Annals of Neurology 53: 292-304. (Review)
Bradl M, Hohlfeld R (2003) Neuroscience for Neurologists: Molecular pathogenesis of neuroinflammation. Journal of Neurology, Neurosurgery and Psychiatry 74: 1364-1370 (Review)
Hohlfeld R, Dalakas M (2003). Basic principles of immunotherapy for neurologic diseases. Seminars in Neurology 23: 121-131 (Review)
2002
Abdul-Majid KB, Stefferl A, Bourquin C, Lassmann H, Linington C, Olsson T, Kleinau S, Harris RA (2002). Fc receptors are crititcal for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scandinavian Journal of Immunology 55: 70-81
Andersson M, Yu M, Soderstrom M, Weerth S, Baig S, Linington C, Solders G, Link H (2002). Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. European Journal of Neurology 9:243-251
Bauer J, Bradl M, Klein M, Leisser M, Deckwerth TL, Wekerle H, Laßmann H (2002). Endoplasmic reticulum stress in PLP overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathol. Experimental Neurology 61:12-22
Berninger B, Bi GQ (2002). Synaptic modification in neural circuits: a timely action. BioEssays 24:212-222
Bradl M, Flügel A (2002). The role of T cells in brain pathology. Curr Top Microbiol Immunol. 265:141-62
Burger B, Uhlhaas S, Jenne D, Dockter G, Back W, Mangold E, Propping P, Friedl W (2002). Novel de novo mutation of MADH4/SMAD4 in a patient with juvenile polyposis. American Journal Med Genet. 110:289-291
Campbel PK, Waymire KG, Heier RL, Shareer C, Day DE, Reimann H, Jaje JM, Friedrich GA, Burmeister M, Bartness TJ, Russell LD, Young LY, Zimmer M, Jenne DE, MacGregor GR (2002). Mutation of a novel gene results in abnormal development of spermatid flagella, loss of inter-male aggression and reduced body fat in mice. Genetics 162:307-320
Clanet M, Radue EW, Kappos L, Hartung HP, Hohlfeld R, Sandberg-Wollheim M, Kooijmans-Coutinho MF, Tsao EC, Sandrock AW and the European IFNß-1a (Avonex) Dose-Comparison Study Investigators (2002). A randomised, double-blind, dose-comparison study of weekly interferon ß-1a in relapsing MS. Neurology 59:1507-1517
Derfuß T, Meinl E (2002). Herpesviral proteins blocking apoptosis. Viral Proteins Counteracting Host Defenses, Koszinowski/Hengel (ed.). Current Topics in Microbiol. and Immunol. Vol. 269:257-268
Farina C, Vargas V, Heydari N, Kümpfel T, Meinl E, Hohlfeld R (2002). Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients. Journal of Neuroimmunology 123:188-192
Farina C, Wagenpfeil S, Hohlfeld R(2002). Immunological assay for assessing the efficacy of glatiramer acetate (Copaxone) in multiple sclerosis: A pilot study. Journal of Neurology 249:1587-1592
Gold R, Linington C (2002). Devic’s disease: bridging the gap between laboratory and clinic. Brain 125:1425-1427
Hammer MH, Schroder G, Risch K, Flugel A, Volk HD, Lehmann M, Ritter T (2002). Antigen-dependent transgene expression in kidney transplantation: a novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol. 13:511-8
Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N(2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc. Natl. Acad. Sci. USA, in press.
Hohlfeld R (2002). How promising is hematopoetic stem cell transplantation in multiple sclerosis? Journal of Neurology 249:1147-1149
Hohlfeld R (2002). Myelin failure in multiple sclerosis: Breaking the spell of Notch. Nature Medicine 8:1075-1076
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H (2002). Role of Lkb1, the causative gene of Peutz–Jegher’s syndrome, in embryogenesis and polyposis. Proc. Natl. Acad. Sci. USA 99:8903-8908
Kirchhoff S, Sebens T, Baumann S, Krueger A, Zawatzky R, Li-Weber M, Meinl E, Neipel F, Fleckenstein B, Krammer PH (2002). Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter. Journal of Immunology 168:1226-1234
Klinkert WEF, Bode W, Jenne DE (2002). The 2.2 Å crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. Journal of Biol. Chem. 277:50923-50933.
Meinl E, Hohlfeld R (2002). Immunopathogenesis of Multiple Sclerosis: MBP and beyond. Clin.Exp.Immunology 128:395-397
Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA (2002). Tumor necrosis factor inhibits outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. Journal of Neuroscience 22:854-862
Oldstone, MBA, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R (2002). Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion. Journal of Virology 76:4357-4363.
Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O´Connor P, Monaghan E, Li D, Weinshenker B, and the EVIDENCE Study Group and the University of British Columbia MS/MRI Research Group (2002). Randomized, comparative study of interferon ß-1a treatment regimes in MS: The EVIDENCE Trial. Neurology 59:1496-1506
Popovic N, Schubart A, Goetz BD, Zhang SC, Linington C, Duncan ID (2002). Inhibition of autoimmune encephalomyelitis by a tetracycline. Annals of Neurology 51:215-223
Scolding NJ, Wilson H, Hohlfeld R, Polman C, Leite I, Gilhus N (The EFNS Cerebral Vasculitis Task Force) (2002). The recognition, diagnosis and management of cerebral vascultitis: a European survey. European Journal of Neurology 9:343-347
Stadelmann C, Kerschensteiner M, Misgeld T, Brück W, Hohlfeld R, Lassmann H (2002). BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 125:75-85
Storch MK, Weissert R, Stefferl A, Birnbacher R, Wallstrom E, Dahlman I, Ostensson CG, Linington C, Olsson T, Lassmann H (2002). MHC gene related effects on microglia and macrophages in experimental autoimmune encephalomyelitis determine the extent of axonal injury. Brain Pathology 12:287-299
Wekerle H (2002). Tackling multiple sclerosis. Nature 420: 39-40
Wekerle H (2002). Immune protection of the brain – efficient and delicate. J. Infect. Dis. 186:140-144
Wiendl H., Hohlfeld R. (2002) Therapeutic approaches in multiple sclerosis: Lessons from failed and interrupted treatment trials. Biodrugs 16: 183-2000. (Review)
Wiendl H, Malotka J, Holzwarth B, Weltzien HU, Wekerle H, Hohlfeld R, Dornmair K (2002). An autoreactive gamma delta TCR derived from a polymyositis lesion. Journal of Immunology 169:515-521
Ziemssen T, Neuhaus O, Hohlfeld R (2002). Risk-benefit assessment of glatiramer acetate in multiple sclerosis. Drug safety 24:979-990
Ziemssen T, Kümpfel T, Klinkert WEF, Neuhaus O, Hohlfeld R (2002). Glatiramer actate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain 125:2381-2391
2001
Altare F, Ensser A, Breiman A, Reichenbach J, Baghdadi J E, Fischer A, Emile J F, Gaillard J L, Meinl E, Casanova J (2001). Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis. J.Infect.Dis. 184:231-236
Brünig I, Penschuck S, Berninger B, Benson J, Fritschy J M (2001). BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABAA receptor surface expression. European Journal of Neuroscience 13 : 1320-1328
Bußhoff U, Hein A, Iglesias A, Dörries R, Régnier-Vigouroux A (2001). CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination. J. Neuroimmunol. 113: 220-230
Daubenberger C A, Nickel B, Hübner B, Siegler U, Meinl E, Pluschke G (2001). Herpesvirus saimiri transformed T cells and peripheral blood mononuclear cells restimulate identical antigen-specific human T cell clones. J Immunol Methods 254:99-108
Derfuss T, Guerkov R, Then Bergh F, Goebels N, Hartmann M, Barz C, Wilske B, Autenrieth I, Wick M, Hohlfeld R, Meinl E (2001). Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 124:1325-1333
Derfuss T, Hohlfeld R, Meinl,E (2001). Multiple Sklerose: Chlamydien-Hypothese in der Diskussion. Der Nervenarzt 72: 820-823
Egg R, Reindl M, Deisenhammer F, Linington C, Berger T (2001). Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis. Multiple Sclerosis 7(5): 285-289
Farina C, Then Berg F, Albrecht H, Meinl E, Yassouridis A, Neuhaus O, Hohlfeld R (2001). Treatment of multiple sclerosis with Copaxone (COP). Elispot assay detects COP-induced interleukin-4 and interferon-g response in blood cells. Brain 124:705-719
Flügel A, Hager G, Horvat A, Spitzer C, Singer G, Graeber M B, Kreutzberg, GW, Schwaiger W (2001). Neuronal MCP-1 expression in response to remote nerve injury.Journal of Cerebral Blood Flow and Metabolism 21: 69-76
Flügel A, Bradl M, Kreutzberg G W, Graeber, M B (2001). Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy.Journal of Neuroscience Research 66:74-82
Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne D, Li Z, Ellwart J, Willem M, Wekerle H (2001). Migratory activity and functional changes of autoimmune T cells preceding and during experimental autoimmune encephalomyelitis: A study of genetically engineered green fluorescent effector cells. Immunity 14:547-560
Flügel A, Bradl M (2001). New tools to trace populations of inflammatory cells in the CNS. Glia 36:125-136
Flügel A, Matsumoru K, Neumann H, Klinkert WEF, Birnbacher R, Lassmann H, Otten U and Wekerle H (2001). Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalitis: inhibition of monocyte transendothelial migration. Eur. J. Immunol. 31: 11-22
Haase C G, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, Schneidewind JM, Zettl UK, Heidenreich F, Berger T, Wekerle H, Hohlfeld R, Linington C (2001). The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J.Neuroimmunol. 114: 220-225
Hackstein H, Bitsch A, Bohnert A, Hofmann H, Weber F, Ohly A, Linington C, Mäurer M, Poser S, Rieckmann P, Bein G (2001) Analysis of interleukin-4 receptor a variants in multiple sclerosis. J. Neuroimmunol. 113:240-248
Henning G, Kraft MS, Derfuss T, Pirzer R, de Saint-Basile G, Aversa G, Fleckenstein B, Meinl E (2001). Signaling lymphocytic activation molecule regulates T cellular cytotoxicity. Eur. J. Immunol.31:2741-2750
Hohlfeld R, Wekerle H (2001). Immunological update on multiple sclerosis. Current Opinion in Neurology 14: 299-304
Hohlfeld R, Wiendl H (2001). The ups and downs of Multiple Sclerosis therapeutics. Annals of Neurology 49: 281-284
Holz A, Brett K, Oldstone M B A (2001). Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes. Journal of Clinical Investigation 108: 1749-1758
Iglesias A (2001). Maintenance and loss of self-tolerance in B cells. Springer Semin Immunopathol 23:351-366
Iglesias A, Bauer J, Litzenburger T, Schubart A, Linington C (2001). T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36:220-234
Iglesias, A, Litzenburger T and Wekerle H (2001): Pathogenesis of Multiple Sclerosis - Tracking the elusive role of B lymphocytes In:Genes and viruses in multiple sclerosis. Eds: Hommes OR, Clanet M, Wekerle H. Elsevier Science, 1-8
Jenne D E, Tinschert S, Reimann H, Lasinger W, Thiel G, Kehrer-Sawatzki H (2001). Molecular characterization of breakpoint boundaries in NF1 patients with long range deletions. American Journal of Human Genetic 69: 516-527
Kornek B, Storch M K, Bauer J, Djamshidian A, Weissert R, Wallstroem E, Stefferl A, Zimprich F, Olsson T, Linington C, Schmidbauer M, Lassmann H (2001). Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 124: 1114-1124
Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A (2001). Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1ß.J. Immunol. 167:1989-1995
Lassmann H, Wekerle H, Hickey W F, Antel, J (2001). Editorial. Glia 36:117
Liblau R, Fontaine B, Baron-Van Evercooren A, Wekerle H, Lassmann, H (2001). Demyelinating diseases: From pathogenesis to repair strategies. Trends in Neurosciences 24: 134-135
Medana I, Li Z, Flügel A, Tschopp J, Wekerle H, Neumann H (2001). FasL (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity.Journal of Immunology 167(2): 674-81
Medana I, Martinique M M A, Wekerle H, Neumann H (2001). Transection of MHC class I-induced neuritis by cytotoxic T lymphocytes. American Journal of Pathology 159: 817-824
Meinl E, Derfuss T, Pirzer R, Blank N, Lengenfelder D, Blancher A, Le Deist F, Fleckenstein B, Hivroz C (2001).Herpesvirus saimiri replaces ZAP-70 for CD3 and CD2-mediated T cell activation.J.Biol.Chem. 276: 36902-36908
Meinl E, Voltz R (2001). Immunologie des Demyelinisations- und Remyelinisationsprozesses. In: Multiple Sklerose, 3. Auflage. Editoren Schmidt R M, Hoffmann F, Urban & Fischer 35-43
Neipel F, Meinl E (2001). Human Herpesvirus-8: Dysregulation of cell growth and apoptosis. In Viruses, Cell Transformation and Cancer. RJA Grand, ed. AJ Zimmermann and I Mushahawar, series editors.eds. Elsevier Amsterdam 291-308
Neuhaus O, Farina C, Wekerle H, Hohlfeld R (2001). Mechanisms of action of glatiramer acetate in multiple sclerosis. Neurology 56: 702-708
Neumann H (2001). Control of glial immune function by neurons. Glia 36: 191-199
Owens T, Wekerle H, Antel J (2001). Genetic models for CNS inflammation. Nature Medicine. 7: 161-165
Patterson JB, Cornu TJ, Redwine J, Dales S, Lewicki H, Holz A, Thomas D, Billeter MA, Oldstone MBA (2001). Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively co - atributes to the chronic progressive CNS disease. Virology 291: 215-225
Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernández-Klett F, Prass K, Bechmann I, de Boer B A, Frotscher M, Kreutzberg G W, Persons D A, Dirnagl U (2001). Targeting of gene-modified hematopoietic cells to the central nervous system: use of the green fluorescent protein uncovers microglial engraftment. Nature Medicine 7:1356-1361
Schmidt S, Haase C G, Bezman L, Moser H, Schmidt M, Kohler W, Linington C, Klockgether T (2001). Serum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis. Journal of Neuroimmunology 119(1): 88-94
Stefferl A, Storch MK, Linington C, Stadelmann C, Lassmann H, Pohl T, Holsboer F, Tilders FJH, Reul JMHM (2001) Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone. Endocrinology 142: 3616-3624
Sun D, Whitaker N J, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS (2001) Myelin antigen-specific CD8* T cells are encephalitogenic and produce severe disease in C57BL/6 mice. The Journal of Immunology 166: 7579-7587
Weissert R, de Graaf K L, Storch, M K, Barth S, Linington C, Lassmann H and Olsson T (2001) MHC class II-regulated Central Nervous System autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis. J. Immunol. 166: 7588-7599
Yang HAT, Bergsteinsdottir K, Wernhoff P, Linington C, Pettersson U Holmdahl R (2001): Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate. Journal of Neuroimmunology 117: 21-29
2000
Bourquin C, Iglesias A, Berger T, Wekerle H, Linington C (2000). DNA vaccination induced autoaggression: Exacerbation of experimental autoimmune encephalitis (EAE) following DNA vaccination with myelin oligodendrocyte glycoprotein. Eur. J. Immunol. 30: 3663-3671
Jenne DE, Tinschert S, Stegmann E, Reimann H, Nürnberg P, Horn D, Ilka Naumann I, Buske A and Thiel G (2000). A common set of at least 11 functional genes are lost in the majority of NF1 patients with gross deletions. Genomics 66: 93-97
Medana I, Gallimore A, Oxenius A, Martinic M, Wekerle H, Neumann H (2000). MHC class I-restricted killing of neurons by virus specific CD8+ T-lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur. J. Imm. 30: 3623-3633
Litzenburger T, Blüthmann H, Morales P, Pham-Dinh D, Dautigny A, Wekerle H, Iglesias A (2000). Development of MOG autoreactive transgenic B lymphocytes: Receptor editing in vivo following encounter of a self-antigen distinct from MOG. J Immunol165: 5360-5366
Meinl E, Lengenfelder D, Blank N, Pirzer R, Barata L. Hivroz C (2000) Differential requirements of ZAP-70 for CD2-mediated pathways of mature human T cells. J Immunol. 165: 3578-3583
Wiendl H, Behrens L, Maier S, Johnson MA, Weiss EH, Hohlfeld R (2000). Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G. Ann Neurol 48: 679-684
Neuhaus O, Farina C, Yassouridis A, Wiendl H, Bergh FT, Dose T, Wekerle H, Hohlfeld R (2000). Multiple sclerosis: Comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proceedings of the National Academy of Sciences of the United States of America 97: 7452-7457
Fluegel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, Kreutzberg GW, Graeber MB (2000). Neuronal FasL induces cell death of encephalitogenic T lymphocytes. Brain Pathology 10: 353-364
Moreira ES, Wiltshire TJ, Faulkner G, Nilforoushan A, Vainzof M, Suzuki O, Valle G, Reeves R, Zatz M, Passos-Bueno MR, Jenne DE (2000). Identification of the gene causing a novel form of limb-girdle muscular dystrophy. Nature Genet. 24: 163-166
Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H (2000). The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. Journal of Neuroimmunology 107 161-166
Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R (2000). Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain 123 Pt 3: 508-518
Meinl E, Hohlfeld R (2000). T cell transformation with Herpesvirus saimiri: a tool for neuroimmunological research. Journal of Neuroimmunology 103: 1-7
1999
Bradl, M, Bauer, J, Inomata, T, Zielasek, J, Nave, KA, Toyka, K, Lassmann, and Wekerle, H (1999). Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathologica 97: 595-606
Padberg F, Matsuda M, Fenk R, Patenge N, Kubuschok, B, Hohlfeld R, Wekerle H, Spuler, S. (1999). Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures. European Journal of Immunology 29:3538-3548
Fernández-Miguel G, Alarcón B, Iglesias A, Blüthmann H, Alvarez-Mon, Sanz E, de la Hera A (1999). Multivalent structure of an abT cell receptor. Proc. Nat. Acad. Sci. USA. 96: 1547-1552
Meinl, E. (1999) Concepts of viral pathogenesis of multiple sclerosis. Curr. Opin. Neurol. 12: 303-307
Wilharm E, Parry MAA, Friebel R, Tschesche H, Matschiner G, Sommerhoff CP, Jenne DE (1999) Generation of catalytically active granzyme K form E. coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma. J. Biol. Chem. 274: 27331-27337
Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R (1999) Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 122: 2089-2100
Brehm U, Piddlesden SJ, Gardinier MV, Linington C (1999) Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG). Journal of Neuroimmunology 97: 9-15
Flügel A, Willem M, Berkowicz T, Wekerle H (1999) Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nature Medicine 5: 843-847
Stefferl, A., Brehm, U., Storch, M., Lambracht-Washington, D., Bourquin, C., Wonigeit, K., Lassmann, H., and Linington, C. (1999). Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. Journal of Immunology 163: 40-49
Friedl W, Kruse R, Uhlhaas S, Stolte M, Keller KM, Jungck M, Stern M, Loff S, Back W, Propping P, Jenne DE (1999). Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients. Genes, Chromosomes & Cancer 25: 403-406
Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999) Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? Journal of Experimental Medicine 189: 865-870
Weerth S, Berger T, Lassmann H, Linington C (1999) Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat. Journal of Neuroimmunology 95: 157-164
Wekerle H (1999) Remembering MOG: autoantibody mediated demyelination in multiple sclerosis? Nature Medicine 5: 153-154
Stefferl A, Linington C, Holsboer F, Reul JM (1999) Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat. Endocrinology 140: 4932-4938
Wong ETL, Jenne DE, Porter SD, Gilks CB (1999) Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation. Blood 94: 3730-3736
1998
Wekerle H (1998) The viral triggering of autoimmune disease. Nature Medicine 4: 770-771
Behrens L, Kerschensteiner M, Misgeld T, Goebels N, Wekerle H, Hohlfeld R (1998) Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions [published erratum appears in J Immunol 2000 May 15;164(10):5330]. Journal of Immunology 161: 5943-5951
Schwaeble WJ, Stover CM, Schall TJ, Dairaghi, DJ, Trinder PKE, Linington C, Iglesias A, Schubart A, Lynch NJ, Weihe E, Schäfer MKH (1998) Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Letters 439: 203-207
Wekerle H (1998) Immune pathogenesis of multiple sclerosis. Brain autoimmune reactivity and its control by neuronal function. Multiple Sclerosis 4: 136-137
Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender, Giegerich, G, de Waal M, Wekerle H, Hohlfeld R (1998) Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis. Brain 121: 1395-1407
Litzenburger T, Fässler R., Bauer J, Lassmann H, Linington C, Wekerle, Iglesias A (1998) B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice.Journal of Experimental Medicine 188: 169-180
Neumann H, Misgeld T, Matsumuro K, Wekerle H (1998) Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Nat Acad Sci U S A 95: 5779-5784
Bender A, Behrens L, Engel AG, Hohlfeld R (1998) T-cell heterogeneity in muscle lesions of inclusion body myositis. Journal of Neuroimmunology 84: 86-91
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller D, Back W, Zimmer (1998) M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet. 18:38-44
Kaab G, Haarmann I, Wekerle H, Bradl M (1998) The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation. European Journal of Immunology 28: 1499-1506
Neumann H, Wekerle H (1998). Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. Journal of Neuropathology & Experimental Neurology 57: 1-9
1997
Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H (1997) Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. Journal of Experimental Medicine 186: 2023-2031
Hohlfeld R, Engel AG, Goebels N, Behrens L (1997) Cellular immune mechanisms in inflammatory myopathies. Current Opinion in Rheumatology 9: 520-526
Voltz RD, Albrich, WC, Nagele A, Schumm F, Wick M, Freiburg A, Gautel, Thaler, HT, Aarli J, Kirchner T, Hohlfeld,R. (1997) Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. Neurology 49: 1454-1457
Kojima K, Wekerle H, Lassmann H, Berger T, Linington C (1997) Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta.
Journal of Neural Transmission Supplementum. 49:43-51
Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal M, Wekerle H, Hohlfeld R (1997) Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain 120: 1437-1445
Kojima K, Reindl M, Lassmann H, Wekerle H, Linington C (1997) The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus. International Immunology 9: 897-904
Behrens L, Bender A, Johnson MA, Hohlfeld R (1997) Cytotoxic mechanisms in inflammatory myopathies. Co-expression of Fas and protective Bcl-2 in muscle fibres and inflammatory cells. Brain 120: 929-938
Hohlfeld R (1997) Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives. Brain 120: 865-916
Liu X, Linnington C, Webster HD, Lassmann S, Yao DL, Hudson LD, Wekerle H, Kreutzberg GW (1997) Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 47: 531-538
Berger T, Weerth S, Kojima K, Linington C, Wekerle H, Lassmann H (1997) Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Laboratory Investigation 76: 355-364
Meinl E, Fickenscher H, Hoch RM, Malefyt RD, de Waal M, Hart BA, Wekerle H, Hohlfeld R, Fleckenstein B (1997) Growth transformation of antigen-specific T cell lines from rhesus monkeys by herpesvirus saimiri. Virology 229: 175-182
Klinkert WE, Kojima K, Lesslauer W, Rinner W, Lassmann H, Wekerle H (1997) TNF-alpha receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview. Journal of Neuroimmunology 72: 163-168
Meinl E, Hoch RM, Dornmair K, de Waal M, Bontrop RE, Jonker, Lassmann H, Hohlfeld R, Wekerle H, 't, HB (1997) Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. Am J Pathol 150: 445-453
Neumann H, Schmidt H, Cavalie A, Jenne DE, Wekerle H (1997) Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. Journal of Experimental Medicine 185
