Michael Kunst
Michael Kunst
Phone: +49 89 8578 3259
Room: O 115
Eva Laurell
Eva Laurell
Staff scientist
Phone: +49 89 8578 3267
Room: O 102-104
Nouwar Mokayes
Nouwar Mokayes
IT specialist
Phone: +49 89 8578 3551
Room: O 036

Genes - Circuits - Behavior: Cellular-Resolution Brain Map

Cellular-resolution map of the larval zebrafish brain

How many discrete cell types exist in the vertebrate brain and how are they connected? In order to tackle this problem, we are automatically classifying neurons in a high-throughput fashion. The larval zebrafish brain is small but displays the basic architecture that is conserved across vertebrates. We are using a genetic tool that stochastically labels individual neurons with membrane-targeted fluorophores. Labeled neurons are imaged by confocal microscopy at high resolution and reconstructed for quantitative morphological analysis. In order to compare neurons between individual fish, we are registering them to a high-resolution, age-matched standard brain. With support from a local supercomputing center, this database shall become a web-accessible resource for the entire community.

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