Max-Planck-Institut für biologische Intelligenz

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Zeitschriftenartikel (119)

2012

Zeitschriftenartikel

Bruder, J.; Siewert, K.; Obermeier, B.; Malotka, J.; Scheinert, P.; Kellermann, J.; Ueda, T.; Hohlfeld, R.; Dornmair, K.: Target specificity of an autoreactive pathogenic human gamma delta-T cell receptor in myositis. The Journal of Biological Chemistry 287 (25), S. 20986 - 20995 (2012)

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Zeitschriftenartikel

Colombo, E.; Cordiglieri, C.; Melli, G.; Newcombe, J.; Krumbholz, M.; Parada, L. F.; Medico, E.; Hohlfeld, R.; Meinl, E.; Farina, C.: Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. Journal of Experimental Medicine 209 (3), S. 521 - 535 (2012)

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Zeitschriftenartikel

Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin-fixed and paraffin-embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22 (5), S. 607 - 618 (2012)

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Zeitschriftenartikel

Eisele, S.; Krumbholz, M.; Fischer, M.-T.; Mohan, H.; Junker, A.; Arzberger, T.; Hohlfeld, R.; Bradl, M.; Lassmann, H.; Meinl, E.: Prospects of transcript profiling for mRNAs and microRNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathology 22, S. 607 - 618 (2012)

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Zeitschriftenartikel

Hohlfeld, R.: Ion channels boost axonal injury in multiple sclerosis. Nature Medicine 18 (12), S. 1743 - 1745 (2012)

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Zeitschriftenartikel

Hohlfeld, R.; Wekerle, H.: β-Amyloid: Enemy or Remedy? Science translational medicine: Integrating medicine and science 4 (145), 145fs24 (2012)

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Zeitschriftenartikel

Krumbholz, M.; Derfuss, T.; Hohlfeld, R.; Meinl, E.: B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nature Reviews Neurology 8 (11), S. 613 - 623 (2012)

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Zeitschriftenartikel

Mayer, M. C.; Hohlfeld, R.; Meinl, E.: Viability of autoantibody-targets: How to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES 319 (1-2), S. 2 - 7 (2012)

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Zeitschriftenartikel

Ng, J. K. M.; Malotka, J.; Kawakami, N.; Derfuss, T.; Khademi, M.; Olsson, T.; Linington, C.; Odaka, M.; Tackenberg, B.; Pruess, H. et al.; Schwab, J. M.; Harms, L.; Harms, H.; Sommer, C.; Rasband, M. N.; Eshed-Eisenbach, Y.; Peles, E.; Hohlfeld, R.; Yuki, N.; Dornmair, K.; Meinl, E.: Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79 (23), S. 2241 - 2248 (2012)

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Zeitschriftenartikel

Siewert, K.; Malotka, J.; Kawakami, N.; Wekerle, H.; Hohlfeld, R.; Dornmair, K.: Unbiased identification of target antigens of CD8(+) T cells with combinatorial libraries coding for short peptides. Nature Medicine 18 (5), S. 824 - 828 (2012)

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2011

Zeitschriftenartikel

Ivanidze, J.; Hoffmann, R.; Lochmueller, H.; Engel, A. G.; Hohlfeld, R.; Dornmair, K.: Inclusion body myositis laser microdissection reveals differential up-regulation of IFN-gamma signaling cascade in attacked versus nonattacked myofibers. American Journal of Pathology 179 (3), S. 1347 - 1359 (2011)

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Zeitschriftenartikel

Junker, A.; Hohlfeld, R.; Meinl, E.: The emerging role of microRNAs in multiple sclerosis. Nature Reviews Neurology 7 (1), S. 56 - 59 (2011)

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Zeitschriftenartikel

Kümpfel, T.; Gerdes, L.; Flaig, M.; Hohlfeld, R.; Wollenberg, A.: Drug-induced Sweet's syndrome after mitoxantrone therapy in a patient with multiple sclerosis. Multiple Sclerosis Journal 17 (4), S. 495 - 497 (2011)

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Zeitschriftenartikel

Meinl, E.; Derfuss, T.; Krumbholz, M.; Pröbstel, A. K.; Hohlfeld, R.: Humoral autoimmunity in multiple sclerosis. Journal of the Neurological Sciences 306 (1-2), S. 180 - 182 (2011)

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Zeitschriftenartikel

Obermeier, B.; Lovato, L.; Bruck, W.; Forne, I.; Imhof, A.; Mentele, R.; Lottspeich, F.; Turk, K. W.; Willis, S. N.; Wekerle, H. et al.; Hohlfeld, R.; Hafler, D. A.; O'Connor, K. C.; Dornmair, K.: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology 233 (1-2), S. 245 - 248 (2011)

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Zeitschriftenartikel

Pellkofer, H. L.; Krumbholz, M.; Berthele, A.; Hemmer, B.; Gerdes, L. A.; Havla, J.; Bittner, R.; Canis, M.; Meinl, E.; Hohlfeld, R. et al.; Kuempfel, T.: Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 76 (15), S. 1310 - 1315 (2011)

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Zeitschriftenartikel

Pröbstel, A.-K.; Dornmair, K.; Bittner, R.; Sperl, P.; Jenne, D. E.; Magalhaes, S.; Villalobos, A.; Breithaupt, C.; Weissert, R.; Jacob, U. et al.; Krumbholz, M.; Kuempfel, T.; Blaschek, A.; Stark, W.; Gaertner, J.; Pohl, D.; Rostasy, K.; Weber, F.; Forne, I.; Khademi, M.; Olsson, T.; Brilot, F.; Tantsis, E.; Dale, R. C.; Wekerle, H.; Hohlfeld, R.; Banwell, B.; Bar-Or, A.; Meinl, E.; Derfuss, T.: Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77 (6), S. 580 - 588 (2011)

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2010

Zeitschriftenartikel

Blaschek, A.; Lohse, P.; Huss, K.; Borggraefe, I.; Mueller-Felber, W.; Heinen, F.; Hohlfeld, R.; Kümpfel, T.: Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis. Multiple Sclerosis 16 (12), S. 1517 - 1520 (2010)

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Zeitschriftenartikel

Derfuss, T.; Linington, C.; Hohlfeld, R.; Meinl, E.: Axo-glial antigens as targets in multiple sclerosis: Implications for axonal and grey matter injury. Journal of Molecular Medicine 88 (8), S. 753 - 761 (2010)

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Zeitschriftenartikel

Hohlfeld, R.: 'Gimme five': Future challenges in multiple sclerosis. ECTRIMS Lecture 2009. Multiple Sclerosis Journal 16 (1), S. 3 - 14 (2010)

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Zeitschriftenartikel

Kappos, L.; Radue, E. W.; O'Connor, P.; Polman, C.; Hohlfeld, R.; Calabresi, P.; Selmaj, K.; Agoropoulou, C.; Leyk, M.; Zhang-Auberson, L. et al.; Burtin, P.: A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis. New England Journal of Medicine 362 (5), S. 387 - 401 (2010)

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Zeitschriftenartikel

Mohan, H.; Krumbholz, M.; Sharma, R.; Eisele, S.; Junker, A.; Sixt, M.; Newcombe, J.; Wekerle, H.; Hohlfeld, R.; Lassmann, H. et al.; Meinl, E.: Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathology 20 (5), S. 966 - 975 (2010)

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Zeitschriftenartikel

Wekerle, H.; Hohlfeld, R.: Beneficial brain autoimmunity? Brain 133, S. 2182 - 2184 (2010)

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Zeitschriftenartikel

Wekerle, H.; Hohlfeld, R.: Molecular oracles for multiple sclerosis therapy. Nature Medicine 16 (4), S. 376 - 377 (2010)

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Zeitschriftenartikel

Wekerle, H.; Hohlfeld, R.: Zero Tolerance (to Acetylcholine Receptor) and Ways to Overcome It. Annals of Neurology 67 (4), S. 422 - 424 (2010)

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2009

Zeitschriftenartikel

Derfuss, T.; Parikh, K.; Velhin, S.; Braun, M.; Mathey, E.; Krumbholz, M.; Kümpfel, T.; Moldenhauer, A.; Rader, C.; Sonderegger, P. et al.; Pöllmann, W.; Tiefenthaller, C.; Bauer, J.; Lassmann, H.; Wekerle, H.; Karagogeos, D.; Hohlfeld, R.; Linington, C.; Meinl, E.: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proceedings of the National Academy of Sciences of the United States of America 106 (20), S. 8302 - 8307 (2009)

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Zeitschriftenartikel

Dornmair, K.; Meinl, E.; Hohlfeld, R.: Novel approaches for identifying target antigens of autoreactive human B and T cells. Seminars in Immunopathology 31 (4), S. 467 - 477 (2009)

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Zeitschriftenartikel

Hohlfeld, R.: Multiple sclerosis: Human model for EAE? European Journal of Immunology 39 (8), S. 2036 - 2039 (2009)

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Zeitschriftenartikel

Junker, A.; Krumbholz, M.; Eisele, S.; Mohan, H.; Augstein, F.; Bittner, R.; Lassmann, H.; Wekerle, H.; Hohlfeld, R.; Meinl, E.: MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, S. 3342 - 3352 (2009)

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Zeitschriftenartikel

Kerschensteiner, M.; Meinl, E.; Hohlfeld, R.: Neuro-immune crosstalk in CNS. Neuroscience 158 (3), S. 1122 - 1132 (2009)

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Zeitschriftenartikel

Pellkofer, H. L.; Voltz, R.; Goebels, N.; Hohlfeld, R.; Dornmair, K.: Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue. Archives of Neurology 66 (5), S. 655 - 658 (2009)

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2008

Zeitschriftenartikel

Berzi, A.; Ayata, C. K.; Cavalcante, P.; Falcone, C.; Candiago, E.; Motta, T.; Bernasconi, P.; Hohlfeld, R.; Mantegazza, R.; Meinl, E. et al.; Farina, C.: BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. Journal of Neuroimmunology 197 (2), S. 128 - 139 (2008)

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Zeitschriftenartikel

Derfuss, T.; Direskeneli, G. S.; Hohlfeld, R.; Meinl, E.: Autoantigen- und erregerspezifische T- und B-Zellreaktionen bei multipler Sklerose: „Eine unendliche Geschichte”? Aktuelle Neurologie 35 (7), S. 345 - 355 (2008)

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Zeitschriftenartikel

Haghikia, A.; Fischer, M.; Hellwig, K.; Linker, R.; Chan, A.; Hohlfeld, R.; Gold, R.: Open use of natalizumab. Neutralising antibodies and clinical data. Nervenarzt 79 (6), S. 716 - 719 (2008)

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Zeitschriftenartikel

Hoffmann, L. A.; Lohse, P.; König, F. B.; Feneberg, W.; Hohlfeld, R.; Kümpfel, T.: TNFRSF1A R92Q mutation in association with a multiple sclerosis-like demyelinating syndrome. Neurology 70 (13 Pt 2), S. 1155 - 1156 (2008)

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Zeitschriftenartikel

Hohlfeld, R.: Neurotrophic cross-talk between the nervous and immune systems: Relevance for repair strategies in multiple sclerosis? Journal of the Neurological Sciences 265 (1-2), S. 93 - 96 (2008)

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Zeitschriftenartikel

Hohlfeld, R.; Meinl, E.; Dornmair, K.: B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. Journal of Neurological Sciences 274 (1-2), S. 5 - 8 (2008)

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Zeitschriftenartikel

Hohlfeld, R.; Wekerle, H.: Reflections on the "intrathymic pathogenesis" of myasthenia gravis. Journal of Neuroimmunology 201-202, S. 21 - 27 (2008)

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Zeitschriftenartikel

Jarius, S.; Paul, F.; Franciotta, D.; Waters, P.; Zipp, F.; Hohlfeld, R.; Vincent, A.; Wildemann, B.: Mechanisms of disease: Aquaporin-4 antibodies in neuromyelitis optica. Nature Clinical Practice Neurology 4 (4), S. 202 - 214 (2008)

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Zeitschriftenartikel

Krumbholz, M.; Faber, H.; Steinmeyer, F.; Hoffmann, L. A.; Kümpfel, T.; Pellkofer, H.; Derfuss, T.; Ionescu, C.; Starck, M.; Hafner, C. et al.; Hohlfeld, R.; Meinl, E.: Interferon-β increases BAFF levels in multiple sclerosis: Implications for B cell autoimmunity. Brain 131, S. 1455 - 1463 (2008)

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Zeitschriftenartikel

Krumbholz, M.; Meinl, I.; Kümpfel, T.; Hohlfeld, R.; Meinl, E.: Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71 (17), S. 1350 - 1354 (2008)

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Zeitschriftenartikel

Kümpfel, T.; Hoffmann, L. A.; Pellkofer, H.; Pöllmann, W.; Feneberg, W.; Hohlfeld, R.; Lohse, P.: Multiple sclerosis and the TNFRSF1A R92Q mutation: Clinical characteristics of 21 cases. Neurology 71, S. 1812 - 1820 (2008)

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Zeitschriftenartikel

Meinl, E.; Krumbholz, M.; Derfuss, T.; Junker, A.; Hohlfeld, R.: Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis. Journal of Neurological Sciences 274 (1-2), S. 42 - 44 (2008)

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Zeitschriftenartikel

Obermeier, B.; Malotka, J.; Kellermann, J.; Kümpfel, T.; Wekerle, H.; Lottspeich, F.; Mentele, R.; Hohlfeld, R.; Dornmair, K.: Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nature Medicine 14 (6), S. 688 - 693 (2008)

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Zeitschriftenartikel

Sommer, N.; Tackenberg, B.; Hohlfeld, R.: The immunopathogenesis of myasthenia gravis. Handb Clin Neurol 91 (Chapter 5), S. 169 - 212 (2008)

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Zeitschriftenartikel

Wiendl, H.; Toyka, K. V.; Rieckmann, P.; Gold, R.; Hartung, H. P.; Hohlfeld, R.: Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations. Journal of Neurology 255 (10), S. 1449 - 1463 (2008)

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2007

Zeitschriftenartikel

Hoffmann, L. A.; Krumbholz, M.; Faber, H.; Kuempfel, T.; Starck, M.; Pöllmann, W.; Meinl, E.; Hohlfeld, R.: Multiple sclerosis: Relating MxA transcription to anti-interferon-β-neutralizing antibodies. Neurology 68 (12), S. 958 - 959 (2007)

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Zeitschriftenartikel

Hohlfeld, R.; Dornmair, K.: Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69 (21), S. 1966 - 1967 (2007)

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Zeitschriftenartikel

Hohlfeld, R.; Kerschensteiner, M.; Meinl, E.: Dual role of inflammation in CNS disease. Neurology 68 (3), S. 58 - 63 (2007)

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Zeitschriftenartikel

Jarius, S.; Eichhorn, P.; Albert, M. H.; Wagenpfeil, S.; Wick, M.; Belohradsky, B. H.; Hohlfeld, R.; Jenne, D. E.; Voltz, R.: Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFα-dependent and Fc-receptor-independent way. Blood 109 (10), S. 4376 - 4382 (2007)

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