Publications

Publication list up until the year 2017.

2017

Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld H, Krishnamoorthy G, Wekerle H (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. PNAS, doi: 10.1073/pnas.1711233114

Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N (2017). Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. PNAS, doi: 10.1073/pnas.1701806114

Wekerle H (2017). Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers. Trends Immunol 38(7): 483-497

Wekerle H (2017). B Cells in Multiple Sclerosis. Autoimmunity 50(1): 57-60

2016

Wekerle H (2016). The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria. Rheumatology 55(suppl2):ii68-ii75 (invited review)

Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch , Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K (2016). Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. PNAS 113(28): 7864-7869

Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2016). The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol 15: 198-209

Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2016). The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurol 15: 317-331

2015

Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M (2015). Deficiency of the Stroke Relevant Hdac9 Gene Attenuates Atherosclerosis in Accord with Allele-Specific Effects at 7p21.1. Stroke 46(1):197-202, doi: 10.1161/STROKEAHA.114.007213. Epub 2014 Nov 11

Rumble JM, Huber AK, Krishnamoorthy G, Srinivasan A, Giles DA, Zhang X, Wang L, Segal BM (2015). Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med 212:23-35

Wekerle H (2015). Nature plus nurture: the triggering of multiple sclerosis. Swiss Med Wkly 145: w14189, doi: 10.4414/smw.2015.14189

Wekerle H (2015). Vaccination and narcolepsy: Immune link found? Sci Transl Med 7(294):294fs27, doi: 10.1126/scitranslmed.aac7091

Hohlfeld R, Wekerle H (2015). Multiple sclerosis and microbiota. From genome to metagenome? Nervenarzt 86(8):925-33, doi: 10.1007/s00115-014-4248-7

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun 6:7333, doi: 10.1038/ncomms8333

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K (2015). αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm 2(4):e107, doi: 10.1212/NXI.0000000000000107. eCollection 2015

Nicol B, Salou M, Laplaud DA, Wekerle H (2015). The autoimmune concept of multiple sclerosis. Presse Med 44(4 Pt 2):e103-12, doi: 10.1016/j.lpm.2015.02.009. Epub 2015 Mar 23

2014 

Koutrolos M, Berer K, Kawakami N, Wekerle H, Krishnamoorthy G (2014). Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS, Acta Neuropathol Commun 2: 163 

Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, Meinl E (2014). Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination, Acta Neuropathol Commun 2(1):178

Ben-Nun A, Kaushansky N, Kawakami N, Krishnamoorthy G, Berer K, Liblau R, Hohlfeld R, Wekerle H (2014). From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. J Autoimmun S0896-8411(14) 00101-2, doi: 10.1016/j.jaut.2014.06.004

Eberle M, Ebel P, Wegner MS, Männich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, Geisslinger G, Grösch S, Schiffmann S (2014). Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol 92: 326-335

Berer K, Boziki M, Krishnamoorthy G (2014). Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS ONE 9(2): e87876

Nischwitz S, Faber H, Sämann PG, Domingues HS, Krishnamoorthy G, Knop M, Müller-Sarnowski F, Yassouridis A, Weber F (2014). Interferon beta-1a reduces increased interleukin-16 levels in MS patients. Acta Neurol Scand 130: 46-52

Berer K, Krishnamoorthy G (2014). Microbial view of central nervous system autoimmunity. FEBS Letters 588: 4207–4213, doi: 10.1016/j.febslet.2014.04.007

Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, Kovalchuk Y, Liang Y, Kalamakis G, Laukat Y, Becker S, Witte G, Geiger A, Allen T, Rome LC, Chen TW, Kim DS, Garaschuk O, Griesinger C, Griesbeck O (2014). Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes. Nat Methods 11(2): 175-182

2013

Wekerle H (2013). Tissue Hypoxia in Autoimmune Brain Disease: A Columbian Discovery? Ann Neurol 74(6): 765-767

Wekerle H, Berer K, Krishnamoorthy G (2013). Remote control - triggering of brain autoimmune disease in the gut. Curr Opin Immunol 25: 1-7

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CCA, Shlomchik MJ, Zamvil SS (2013). MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 210(13): 2921-2937

Wekerle H, Meinl E (2013). Multiple sclerosis: An old drug plays a new trick (News and Views). Nature 502: 314-315

Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld , Banwell B, Bar-Or A, Meinl E (2013).  Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases. J Immunol 191(7): 3594-604

Neumann H, Wekerle H (2013). Brain microglia: Watchdogs with pedigree (News and Views). Nat Neurosci 16(3): 253-255

Mues M, Bartholomäus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G (2013). Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nat Med 19(6):778-784

Pesic M, Bartholomäus I, Kyratsous NI, Heissmeyer V, Wekerle H, Kawakami N (2013). 2-photon imaging of phagocyte-mediated T cell activation in the CNS. J Clin Invest 123(3): 1192–1201

Pohl M, Kawakami N, Kitic M, Bauer J, Martins R, Fischer MT, Machado-Santos J, Mader S, Ellwart JW, Misu T, Fujihara K, Wekerle H, Reindl M, Lassmann H, Bradl M. (2013). T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathol Commun 1: 85

Pesic M, Kawakami N, Bartholomäus I, Kyratsous NI (2013). Imaging of Immune Cell Behavior and Function in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Clin Exp Neuroimmunol 4 (Suppl. 1): 27–35

Kawakami N, Bartholomäus I, Pesic M, Kyratsous NI (2013). Intravital imaging of autoreactive T cells in living animals. Methods Cell Biol 113:149-68

2012

Berer K, Krishnamoorthy G (2012). Commensal gut flora and brain autoimmunity: a love or hate affair? Acta Neuropathol 123(5): 639-51, doi: 10.1007/s00401-012-0949-9

Hohlfeld R (2012). Ion channels boost axonal injury in multiple sclerosis. Nat Med 18: 1743-1745

Direnberger S,  Mues M, Micale V, Wotjak CT, Dietzel S, Schubert M, Scharr A, Hassan S, Wahl-Schott C, Biel M,  Krishnamoorthy G, Griesbeck O (2012). Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model. Nat Comm 3: 1031

Kawakami N, Bartholomäus I, Pesic M, Mues M (2012). An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS. Immunol Rev  248(1): 140-55

Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WEF, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A (2012). T cells become licensed in the lung to enter the central nervous system. Nature 488: 675-679

Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K (2012). Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nat Med 18: 824-829

Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada L, Medico E, Hohlfeld R, Meinl E, Farina C (2012). Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209: 521-535

Wekerle H, Flügel A, Fugger L, Schett G, Serreze DV (2012). Autoimmunity's next top models. Nat Med 18: 66-70

Wekerle H, Krishnamoorthy G (2012). Brain autoimmunity: The CD8 question(s). Immunity 37: 1, 8-10

Hohlfeld R, Wekerle H (2012). β-Amyloid: Enemy or Remedy? Sci Translat Med 4: 145fs24

Elliott C, Lindner M, Arthur A, Brennan K, Jarius S, Hussey J, Chan A, Stroet A, Olsson T, Willison H, Barnett SC, Meinl E, Linington C (2012). Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135: 1819-1833

Bruder J, Siewert K, Obermeier B, Malotka J, Scheinert P, Kellermann J, Ueda T, Hohlfeld R, Dornmair K (2012). Target specificity of an autoreactive γδ-T cell receptor in myositis. J Biol Chem 287: 20986-95

Ng JK, Malotka J, Kawakami N, Derfuss T, Khademi M, Olsson T, Linington C, Odaka M, Tackenberg B, Prüss H, Schwab JM, Harms L, Harms H, Sommer C, Rasband MN, Eshed-Eisenbach Y, Peles E, Hohlfeld R, Yuki N, Dornmair K, Meinl E (2012). Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79(23): 2241-2248, doi: 10.1212/WNL.0b013e31827689ad. Epub 2012 Oct 24.

Meinl E, Meister G (2012). MicroRNAs in the CSF: Macro-advance in MS? Neurology, 79(22): 2162-2163, Epub 2012 Oct 17.

Eisele S, Krumbholz M, Fischer MT, Mohan H, Junker A, Arzberger T, Hohlfeld R, Bradl M, Lassmann H, Meinl E (2012). Prospects of transcript profiling for mRNAs and micro RNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathol 22: 607-618

Kim SM, Bhonsle L, Besgen P, Nickel J, Vollmer S, Backes A, Held K, Vollmer S, Dornmair K, Prinz JC (2012). Analysis of the paired TCR α- and β-chains of single human T cells. PLoS ONE 7(5): e37338

Krumbholz M, Derfuss T, Hohlfeld R, Meinl E (2012). B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol 8(6): 13-623

Derfuss T, Meinl E (2012). Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment? Curr Opin Neurol 25: 231-238

Mayer MC, Hohlfeld R, Meinl E (2012). Viability of autoantibody-targets: how to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis. J Neurol Sci 319: 2-7

Mayer MC, Meinl E (2012). Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Ther Adv Neurol Disord 5: 147-159

Lippok S, Seidel SAI, Duhr S, Uhland K,Holthoff HP, Jenne D, Braun D (2012). Direct Detection of Antibody Concentration and Affinity in Human Serum Using Microscale Thermophoresis, Anal Chem 84(8): 3523-3530, doi: 10.1021/ac202923j

Hedberg C, Melberg A, Kuhl A, Jenne D, Oldfors A (2012). Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation, Eur J Hum Genet 20(9): 984-985, doi: 10.1038/ejhg.2012.39

Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE (2012). NSP4, an elastase-related protease in human neutrophils with arginine specificity, Proc Natl Acad Sci USA 109(16): 6229-6234, doi: 10.1073/pnas.1200470109

Mankan AK, Dau T, Jenne D, Hornung V (2012). The NLRP3/ASC/Caspase-1 axis regulates IL-1 ss processing in neutrophils, Eur J Immunol 4(3): 710-717, doi: 10.1002/eji.201141921

2011

Berer K, Mues M, Koutroulos M, Al Rasbi Z, Boziki M, Johner C, Wekerle H, Krishnamoorthy G (2011). Commensal microbiota and myelin autoantigen cooperate to trigger T/B cell mediated spontaneous EAE, a model for relapsing-remitting multiple sclerosis. Nature 479: 538-541

Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T (2011). Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J Virol 85(19): 9680-5 

Pellkofer HL, Krumbholz M, Berthele A, Hemmer B, Gerdes LA, Havla J, Bittner R, Canis M, Meinl E, Hohlfeld R, Kuempfel T (2011). Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 76(15): 1310-5

Ivanidze J, Hoffmann R, Lochmüller H, Engel AG, Hohlfeld, R*, Dornmair K* (2011). Inclusion Body Myositis: Laser microdissection reveals differential upregulation of IFN gamma signaling cascade in attacked versus non-attacked myofibers. Am J Pathol 179: 1347-1359

Junker A, Hohlfeld R, Meinl E (2011). The emerging role of microRNAs in multiple sclerosis. Nat Rev Neurol 7: 56-59

Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B*, Bar-Or A*, Meinl E*, Derfuss T* (2011) Antobodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77(6):580-8, * equal contribution

Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM (2011). Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology 140(4): 1272-82

Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW (2011). Neurotophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunol 186(2): 1131-9

Fitzner D, Schnaars M, van Rossum D, Krishnamoorthy G, Dibaj P, Bakhti M, Regen T, Hanisch UK, Simons M (2011). Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci 124: 447-458

Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K (2011). Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol 233: 245-248

Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A (2011). Highly skewed T- cell receptor V beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal 1, doi:10.1038/bcj.2011.6.

Berer K, Wekerle H, Krishnamoorthy G (2011). B cells in spontaneous autoimmune diseases of the central nervous system. Mol Immunol 48: 1332-1337

Kessenbrock K, Dau T, Jenne DE (2011). Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med 89: 23-28

Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard WI, Li H, Holsboer F, Turck CW, Touma, C (2011). Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res 220: 305-311

2010

Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G (2010). Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. PLOS ONE 5(11): e15531

Silva F, Hummel AM, Jenne DE, Specks U (2010). Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's, J Autoimmun 35(4): 299-308

Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (2010). Neutrophil elastase, proteinase 3 and cathepsin G as therapeutic targets in human diseases, Pharmacol Rev 62(4): 726-59

Kawakami N, Flügel A (2010). Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Semin Immunopathol 32: 275-287

Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A (2010). Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133: 1930-1943

Kurschus FC, Jenne DE (2010) .Delivery and therapeutic potential of human Granzyme B. Immunological Rev 235: 159-171

Kuhl A, Korkmaz B, Utecht B, Kniepert A, Schönermarck U, Specks U, Jenne DE (2010). Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener’s granulomatosis. J Immunology, 185: 387-399

Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E (2010). Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are up-regulated and associated with infiltrating immune cells. Brain Pathol 20: 966-975

Wekerle H and Hohlfeld R (2010). Molecular oracles for multiple sclerosis therapy. Nat Med 16(4): 376-377

Wekerle H and Hohlfeld R (2010). Zero tolerance (to AChR) and ways to overcome it. Ann Neurol 67(4): 422-424

2009

Dornmair K, Meinl E, Hohlfeld R (2009). Novel approaches for identifying target antigens of autoreactive human B and T cells. Semin Immunopathol 31: 467-477

Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, Lassmann H, Wekerle H, Hohlfeld R, Meinl E (2009). MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47, Brain  132: 3342-3352

Bartholomäus I*, Kawakami N*, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, Klinkert WEF, Flügel-Koch C, Issekutz TB, Wekerle H, Flügel A (2009). Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature  462(7269): 94-98, * Co-first authors

Krishnamoorthy G, Saxena A, Mars LT, Domingues H.S, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau R, Wekerle H (2009). Myelin specific T cells co-recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med 15(6): 626-632

Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE (2009). Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15(6): 623-625

Pöllinger B, Krishnamoorthy G, Berer K, Lassmann H, Bösl M, Dunn R, Domingues HS, Holz A, Kurschus FC, Wekerle H (2009). Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit MOG-specific endogenous B cells. J Exp Med 206(6): 1303-1316

Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Flügel A, Dockery P, O’Brie T, Howard L, Windebank AJ, Barry FP (2009). Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without diff erentiating into neural cells. Tissue Eng Part A 15(10): 3049-59

Schwab N, Bien CG, Waschbisch A, Becker A, Vince, GH, Dornmair K, Wiendl H (2009). CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132: 1236-1246

Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K (2009). Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol 66(5): 655-658

Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C, Meinl E (2009). Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci USA 106: 8302-8307

Kurschus F, Paramita Pal P, Bäumler P, Jenne DE, Wiltschi B, Budisa N (2009). Gold fluorescent annexin A5 as a novel apoptosis detection tool. Cytometry, 75A: 626-633

Romero V, Fellows E, Jenne DE, Andrade F (2009). Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death Differ 16(2): 340-348

Hohlfeld R (2009). Multiple sclerosis: Human model for EAE? Eur J Immunol 39(8): 2036-2039

Krishnamoorthy G, Wekerle H (2009). EAE: An immunologist’s Magic Eye. Eur J Immunol 39(8): 2031-2035

Kerschensteiner M, Meinl E, Hohlfeld R (2009). Neuro-immune crosstalk in CNS diseases. Neuroscience 158(3): 1122-1132

Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T (2009). Nonfunctional regulatory T cells and defective control of Th2-cytokine production in natural scurfy mutant mice. J Immunol 183: 5662-5672


2008

Korkmaz B, Kuhl A, Bayat B, Santoso S, Jenne DE (2008). A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. J Biol Chem 283(51): 5976-82,  Epub 2008 Oct 14

Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, Lottspeich F, Hohlfeld R, Dornmair K (2008). Matching of oligoclonal Ig transcripts and proteins of cerebrospinal fluid in multiple sclerosis. Nat Med 14: 688-693

Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE (2008). Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest 118(7): 2438-47

Kurschus FC, Fellows E, Stegmann E, Jenne DE (2008). Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate dependent endocytosis. Proc Natl Acad Sci USA 105: 13799-13804

Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne DE, Holak TA, Werb Z, Sixt M, Wedlich-Söldner R (2008). Lifeact: a versatile marker to visualize F-actin. Nat Methods 5(7): 605-7

Deininger K, Eder M, Kramer E, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R (2008). The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci USA 105: 12539-12544

Krumbholz M*, Faber H*, Steinmeyer F, Hoffmann LA, Kümpfel T, Pellkofer H, Derfuss T, Ionescu C, Starck M, Hafner C, Hohlfeld R, Meinl E (2008). Interferon-ß increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 131: 1455-1463, * equal contribution

Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM (2008). CD28 superagonistic antibodies elicit two functionally distinct waves of T cell activation. J Clin Invest 118(4): 1405-1416

Matheu MP, Beeton C, Garcia A, Uemura MI, Li D, Pal S, de la Maza LM, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD (2008). In situ imaging of effector/memory. T cells during DTH and suppression by Kv1.3 channel block. Immunity 29: 602–614

Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E*, Farina C* (2008). BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. J Neuroimmunol 197: 128-139, *equal contribution

Obermeier B, Mentele R, Malotka J, Dornmair K (2008). Analysis of patient-specific immunoglobulin proteomes and transcriptomes by PCR cloning and mass spectrometry. Nat Protoc, doi: 10.1038/nprot.2008.87

Hohlfeld R, Meinl E, Dornmair K (2008). B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. J Neurol Sci 274(1-2): 5-8

Kuhl A, Melberg A, Meinl E, Nürnberg G, Nürnberg P, Kehrer-Sawatzki H, Jenne DE (2008). Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. Eur J Hum Genet 16: 367-373

Hohlfeld R (2008). Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis? J Neurol Sci 265: 93-96

Meinl E, Krumbholz M, Derfuss T, Junker A, Hohlfeld R (2008). Compartmentalization of inflammation in the CNS: a major mechanism driving progressive multiple sclerosis. J Neurol Sci 274(1-2): 42-4

Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O’ Brien T, Howard L, Windebank AJ, Barry FB (2008). Gene-modified Mesenchymal Stem Cells Express Functionally Active Nerve Growth Factor on an Engineered Poly Lactic Glycolic Acid (PLGA) Substrate. Tissue Engineering Part A, 14(5):681-90

Krumbholz M, Meinl I, Kümpfel T, Hohlfeld R, Meinl E (2008). Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 71: 1350-1354

Bradl M, Dornmair K, Hohlfeld R (2008). New tools for investigating the immunopathogenesis of MS: Principles and applications. In: Multiple Sclerosis: A Comprehensive Text (Raine CS, McFarland HF, Hohlfeld R eds). Saunders, Elsevier, Edinburgh. p 284-299

2007

Mathey EK*, Derfuss T*, Storch MK, Williams KR, Hales K, Woolley DR, Al-Hayani A, Davies SN, Rasband M, Velhin S, Olsson T, Moldenhauer A, Hohlfeld R, Meinl E*, Linington C* (2007). Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med 204: 2363-2372, * contributed equally

Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell death program. Blood 110: 544-552

Odoardi F, Kawakami N, Klinkert WEF, Wekerle H, Flügel A (2007). Blood-born soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc Natl Acad Sci USA 104: 18625-18630

Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WEF, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A (2007). Instant effect of soluble autoantigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc Natl Acad Sci USA 16: 920-25

Dorn T, Kuhn U, Bungartz G, Stiller S, Bauer M, Ellwart J, Peters T, Scharffetter-Kochanek K, Semmrich M, Laschinger M, Holzmann B, Klinkert WEF, Straten PT, Kollgaard T, Sixt M, Brakebusch C (2007). RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood 109: 2346-2355

Jarius S, Eichhorn P, Albert MH, Wagenpfeil S, Wick M, Belohradsky BH, Hohlfeld R, Jenne DE, Voltz R (2007). Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNF alpha-dependent and Fc-receptor-independent way. Blood 109: 4376-4382

Junker A*, Ivanidze J*, Malotka J, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K (2007). Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130: 2789-2799, *equal contribution

Junker A, Ivanidze J, Malotka J, Eiglmeier I, Lassmann H, Wekerle H, Meinl E, Hohlfeld R, Dornmair K (2007). Multiple Sclerosis: T cell receptor expression in distinct brain regions. Brain 130: 2789-2799

Krishnamoorthy G, Holz A, Wekerle H (2007). Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 84: 1161-1173

Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl H (2007). Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. Mol Cell Neurosci 36: 416-424

Grundtner R, Dornmair K, Dahm R, Flügel A, Kawakami N, Zeitelhofer M, Schoderboeck L, Nosov M, Selzer E, Willheim M, Kiebler M, Wekerle H, Lassmann H, Bradl M (2007). Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiol Dis 28: 261-275

Hohlfeld R, Dornmair K (2007). Revisiting the immunopathogenesis of the inflammatory myopathies. Neurology 69: 1966-1967

Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus H-G, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D (2007). Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia. Brain Pathology 17: 389-398

Krumbholz M, Theil D, Steinmeyer F, Cepok S, Hemmer B, Hofbauer M, Farina C, Derfuss T, Junker A, Arzberger T, Sinicina I, Hartle C, Newcombe J, Hohlfeld R, Meinl, E (2007). CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol 190: 72-79

Flügel A, Odoardi F, Nosov M, Kawakami N (2007). Autoaggressive effector T cells in the course of Experimental Autoimmune Encephalomyelitis visualized in the light of two-photon microscopy. J Neuroimmunol 191: 86-97

Wekerle H, Flügel A (2007). Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis. In “Molecular Neurology” (S Waxman ed.) Elsevier, pp 475-497

Wekerle H, Kurschus FC (2007). Disease Models. Drug Discov Today 3: 359-367

Farina C, Aloisi F, Meinl E (2007). Astrocytes are active players in cerebral innate immunity. Trends Immunol 28: 138-145

Hoffmann LA, Krumbholz M, Faber H, Kümpfel T, Starck M, Pöllmann W, Meinl E, Hohlfeld R (2007). Multiple Sclerosis: Relating MxA transcription to anti-interferon-beta neutralizing antibodies. Neurology, 68: 958-959

Hohlfeld R, Kerschensteiner M, Meinl E (2007). Dual role of inflammation in CNS disease. Neurology 68(22 Suppl 3): S58-S63

Jenne DE, Aries PM, Einwächter S, Akkad AD, Wieczorek S, Lamprecht P, Gross WL (2007). The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis. An Rheum Dis 66: 1266-1267

Krumbholz M, Pellkofer H, Gold R et al (2007). Delayed allergic reaction to natalizumab associated with early formation of neutralizing antibodies. Arch Neurol 64(9): 1331-1333

Klatt J, Hartung HP, Hohlfeld R (2007). FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis. Nervenarzt 78(10): 1200-1208

Weber MS, Hohlfeld R, Zamvil SS (2007). Mechanism of action of glatiramer acetate in treatment of multiple sclerosis. Neurotherapeutics 4(4): 647-653

Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WEF, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A (2007). Instant effect of soluble autoantigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc Natl Acad Sci USA  104: 920-925

2006

Seitz S, Schneider CK, Malotka J, Nong X, Engel, AG, Wekerle H, Hohlfeld R, and Dornmair K (2006). Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of frozen human tissues. Proc Natl Acad Sci USA 103: 12057-12062

Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang L, Potter BVL, Guse AH (2006). Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. Brit J Pharmacol 149(4): 337-44

Krishnamoorthy G, Lassmann, H, Wekerle H, Holz A (2006). Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 116: 2385-2392

Meinl E, Krumbholz M, Hohlfeld R (2006). B lineage cells in the inflammatory CNS environment. Ann Neurol 59: 880-892

Krumbholz M, Theil D, Cepok S, Hemmer B, Kivisakk P, Ransohoff R M, Hofbauer M, Farina C, Derfuss T, Hartle C, Newcombe J, Hohlfeld R, and Meinl E (2006). Chemokines in MS: CXCL12 and CXCL13 upregulation is differentially linked to CNS immune cell recruitment. Brain 129: 200-211

2005

Flügel A, Kawakami N (2005). Immune processes in the light of Two-photon microscopy. In “Leukocyte Trafficking” (A Hamann, Engelhardt B eds.) Wiley-VCH, pp 472-496

Krumbholz M, Specks U, Wick M, Kalled S L, Jenne D, Meinl E (2005). BAFF is elevated in serum of patients with Wegener’s granulomatosis. J Autoimmun 25: 298-302

Bade B, Boettcher HE, Lohrmann J, Hink-Schauer C, Bratke K, Jenne DE, Virchow JC, Luttmann W (2005). Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. Int Immunol 17(11): 1419-1428

Zagrebelsky M, Holz A, Dechant G, Barde Y A, Bonhoeffer T and Korte M (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neuroscie 25(43): 9989-9999

Wiesner O, Litwiller RD, Hummel AM, Viss MA, McDonald CJ, Jenne DE, Fass DN, Specks U (2005). Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments. FEBS Letters 579(24): 5305-5312

Farina C, Weber MS, Meinl E, Wekerle H, Hohlfeld R (2005). Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurol 4(9): 567-575

Spiegel M, Oexle K, Horn D, Windt E, Buske A, Albrecht B, Prott EC, Seemanova E, Seidel J, Rosenbaum T, Jenne DE, Kehrer-Sawatzki HK, Tinschert S (2005). Childhood overgrowth in patients with common NF1 microdeletions. Eur J Hum Genet 13(7): 883-888

Ziemssen T, Kümpfel T, Schneider H, Klinkert WEF, Neuhaus O, Hohlfeld R (2005). Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: Implications for multiple sclerosis therapy. J Neurol Sci 233(1-2): 109-112

Bradl M, Bauer J, Flügel A, Wekerle H and Lassmann H (2005). Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. Am J Pathol 166(5): 1441-1450

Derfuss T, Hohlfeld R and Meinl E (2005). Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell response. J Neurol 252(8): 968-971

Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, and Flügel A (2005a). Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med 201(11): 1805-1814

Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu C-M, Kalled SL, Hess DM, Serafini S, Aloisi F, Wekerle H Hohlfeld R, Meinl E (2005). BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 201(2): 195-200

Kawakami N, Odoardi F, Ziemssen T, Bradl M, Ritter T, Neuhaus O, Lassmann H, Wekerle H, Flügel A (2005). Autoimmune CD4+ T Cell Memory: Lifelong Persistence of Encephalitogenic T Cell Clones in Healthy Immune Repertoires. J Immunol 175(1): 69-81

Vargas-Leal V, Bruno R, Derfuss T, Krumbholz M, Hohlfeld R, Meinl E (2005). Expression and function of glial cell line-derived neurotrophic factor (GDNF) family ligands and their receptors on human immune cells.  J Immunol 175: 2301-2308

Kurschus FC, Bruno R, Fellows E, Falk CS, Jenne DE (2005). Membrane receptors are not required to deliver granzyme B during killer cell attack. Blood 105(5): 2049-58

Schmid C, Diem H, Herrman K, Voltz R, Ott G and Hallek M (2005). Central neurogenic hyperventilation as complication of Richter's syndrome. J Clin Oncol 23(9): 2096-2098

Wiendl H, Hohlfeld R, and Kieseier BC (2005). Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends Immunol 26(7):373-80

Jenne DE, Kley RA, Vorgerd M, Schröder JM, Weis J, Reimann H, Albrecht B, Nürnberg P, Thiele H, Müller CR, Meng G, Witt C, Labeit S (2005). Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3. Biol Chem 386: 61-67

Theil D , Farina C, Meinl E (2005). Differential expression of CD150 (SLAM) on monocytes and macrophages in chronic inflammatory contexts: Abundant in Crohn’s disease, but not in multiple sclerosis. J Clin Pathol 58: 110-111

Wekerle H (2005). Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proc Natl Acad Sci USA 102 (Editorial)

Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, Meinl E (2005). Preferential expression and function of Toll-like Receptor 3 in human astrocytes. J Neuroimmunol 159(1-2): 12-19

2004

Kawakami N, Lassmann S,  Li ZX, Odoardi F, Ritter T, Ziemssen T, Klinkert WEF,  Ellwart JW, Bradl M, Krivacic K, Lassmann H, Ransohoff RM, Volk HD,  Wekerle H, Linington C,  Flügel A (2004). The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med 199(2): 185-197

Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R , Goebels N (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci USA 101(8): 2428-2433

Weber MS, Starck M, Wagenpfeil S, Meinl E, Hohlfeld, Farina C (2004). Glatiramer Acetate inhibits monocyte reactivity in vitro and in vivo. Brain 127: 1370-1378

Pfister H, Ollert M, Fröhlich LO, Quintanilla-Fend L, Colby TV, Specks U, Jenne, DE (2004). Autoantibodies against the murine homolog of Wegener’s autoantigen (proteinase 3) are pathogenic in vivo. Blood 104: 1411-1418

Kehrer-Sawatzki H, Kluwe L, Sandig C, Kohn M, Wimmer K, Krammer U, Peyrl A, Jenne DE, Hansmann I, Mautner VF (2004). High frequency of mosaicism among NF1 patients with large deletions in 17q11.2 caused by somatic recombination of the JJAZ1 gene. Am J Hum Genet 75: 410-423

Pellkofer H, Schubart AS, Höftberger R, Schutze N, Pagany M, Schüller M, Lassmann H, Hohlfeld R, Voltz R and Linington C (2004). Modeling paraneoplastic disease: Onconeuronal antigen specific T cells mediate autoimmune encephalomyelitis in the rat. Brain 127: 1822-1830

Linke R, Schröder M , Helmberger T, Voltz R (2004). Antibody-positive paraneoplastic neuroligical syndromes: The value of CT and FDG-PET imaging for tumor diagnosis. Neurology 63(2): 282-286

Wiesner O, Russell KA , Lee AS, Jenne DE , Trimarchi M, Gregorini G and Specks U (2004). Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase: a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Arthritis Rheum 50(9):2 954-2965

Mead R J, Neal JW, Griffiths M R, Linington C , Botto M, Lassmann H, Morgan BP (2004). Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest 84(1): 21-28

Scheid R, Lincke T, Voltz R, Cramon von DY (2004). Serial FDG-PET and MR-imaging of paraneoplastic limbic encephalitis. Arch Neurol 61(11): 1785-1789

Kurschus FC, Kleinschmidt M, Fellows E, Dornmair K, Rudolph R, Lilie H, Jenne DE (2004). Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett. 562(1-3): 87-92

Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R (2004). Fast dissociation kinetics of an autoreactive human Vγ1.3Vδ2 T-cell receptor/antigen complex. J Neuroimmunol 152: 168-175

Farina C, Theil D, Semlinger B, Hohlfeld R, Meinl E (2004). Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines. Internat Immunol 16: 799-809

Flügel A (2004). Gentransfer in Antigen-spezifischen CD4+ T-Zellen: Schicksal und Funktion autoreaktiver T-Zellen im Organismus. Ludwig-Maximilians-Universität München

Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J , Sillevis Smitt P, Vedeler C, Verschuuren JJGM, Vincent A, Voltz R (2004). For the Paraneoplastic Neurological Syndrome Euronetwork. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiat 75(8): 1135-1140

Karrasch T, Weil M, Voltz R, Schulz C, Audebert F, Woenckhaus M, Hofstadter F, Bogdahn U, Schölmerich J, Schaffler A, Steinbrecher A (2004). "Fußkribbeln", Vergesslichkeit und progrediente Wesensveränderung bei einer 63-jährigen Patientin. Internist 45(3): 341-346

Moser CM, Jenne DE, Pfister H, Ollert M, Krombach F (2004). Leukocyte migration in proteinase-3/elastase-2 double mutant mice in vivo. J Vasc Res 41(1): 94-95

Vargas V (2004). Expression and function of GDNF family ligands and their receptors by human immune cells. Ludwig-Maximilians-Universität München

Voltz R, Starck M, Zingler V, Strupp M and Kolb HJ (2004). Mitoxantrone therapy in multiple sclerosis and acute leukaemia: A case report out of 644 treated patients. Multiple Sclerosis 10: 472-474

Hohlfeld R, Wekerle H (2004). Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines (Review) Proc. Natl Acad Sci USA 101 (Suppl. 2): 14599-14606

Ziemssen T (2004). Neuroprotection and glatiramer acetate: The possible role in the treatment of Multiple Sclerosis. Front Clin Neurosci Neurodegeneration and Neuroprotection 541: 111-134

Hohlfeld R (2004). Immunologic factors in primary progressive multiple sclerosis. Mult Scler 10: S16-S22

Jenne DE (2004). Peutz-Jeghers Syndrome. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (edited by K. Ruckpaul and Detlev Ganten) Springer Verlag.

Meinl E, Voltz R (2004). Biomarker in der Therapie der Multiplen Sklerose: Läßt sich der Erfolg bald vorhersagen? MMW-Fortschr Med Sonderheft 2: 57-58

2003

Hink-Schauer C, Estébanez-Perpiñá EE, Kurschus FC, Bode W, Jenne DE (2003). Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat Struct Biol 10: 535-540

Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N (2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc Natl Acad Sci USA 100(7): 4090-4095

Wiendl H, Mitsdoerffer M, HofmeisterV, Wischhusen J, Weiss EH, Dichgans J, Lochmüller H, Hohlfeld R, Melms A, Weller M (2003). The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy. Brain 126: 176-185

Theil D, Derfuss T, Paripovic I, Meinl E, Schueler O, Strupp M, Arbusow V, Brandt T (2003). Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response. Am J Pathol 163: 2179-2184

Dornmair K, Weltzien HU, Goebels N, Wekerle H, Hohlfeld R (2003). T-cell mediated autoimmunity: Novel techniques to characterize autoreactive T cell receptors. Am J Pathol 163: 1215-1226

Arbour N, Holz A, Sipe JC, Naniche D, Romine JS, Zyroff J, Oldstone MBA (2003). A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis. J Neuroimmunol 137: 197-209

Jenne DE, Tinschert S, Dorschner MO, Hameister H, Stephens K, Kehrer-Sawatzki H (2003). Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Gene Chromosome Canc 37: 111-120

Voltz R, Albrich W, Hohlfeld R, Nagel D, Wick M, Kirchner T, Sommer N, Illa I, Kaminski H, Schumm F (2003). Anti-titin antibodies are not associated with a specific thymoma histology. J Neurol Neurosurg Psychiat 74: 282

Wekerle H, Hohlfeld R. Molecular mimicry in multiple sclerosis (2003). New Engl J Med 349: 185-186, Editorial

Hohlfeld R(2003) Hunting (auto)immune T cells in neuroimmunological diseases. Brain 126: 2-4 , Editorial

Kerschensteiner M, Hohlfeld R (2003). Neurotrophic factors protect myelin from attack. Internat MS Journal 10: 2-4, Editorial

Dalakas M, Hohlfeld R. (2003). Polymyositis and dermatomyositis. Lancet 362: 971-982

Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R (2003). Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Ann Neurol 53: 292-304

Bradl M, Hohlfeld R (2003) Neuroscience for Neurologists: Molecular pathogenesis of neuroinflammation. J Neurol Neurosurg Psychiat 74: 1364-1370

Hohlfeld R, Dalakas M (2003). Basic principles of immunotherapy for neurologic diseases. Semin Neurolo 23: 121-131

2002

Abdul-Majid KB, Stefferl A, Bourquin C, Lassmann H, Linington C, Olsson T, Kleinau S, Harris RA (2002). Fc receptors are crititcal for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scand J Immunol 55: 70-81

Andersson M, Yu M, Soderstrom M, Weerth S, Baig S, Linington C, Solders G, Link H (2002). Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. Eur J Neurol 9:243-251

Bauer J, Bradl M, Klein M, Leisser M, Deckwerth TL, Wekerle H, Laßmann H (2002). Endoplasmic reticulum stress in PLP overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathol Exp Neurol 61:12-22

Berninger B, Bi GQ (2002). Synaptic modification in neural circuits: a timely action. BioEssays 24: 212-222

Bradl M, Flügel A (2002). The role of T cells in brain pathology. Curr Top Microbiol Immunol 265: 141-62

Burger B, Uhlhaas S, Jenne D, Dockter G, Back W, Mangold E, Propping P, Friedl W (2002). Novel de novo mutation of MADH4/SMAD4 in a patient with juvenile polyposis. Am J Med Genet 110: 289-291

Campbel PK, Waymire KG, Heier RL, Shareer C, Day DE, Reimann H, Jaje JM, Friedrich GA, Burmeister M, Bartness TJ, Russell LD, Young LY, Zimmer M, Jenne DE, MacGregor GR (2002). Mutation of a novel gene results in abnormal development of spermatid flagella, loss of inter-male aggression and reduced body fat in mice. Genetics 162: 307-320

Clanet M, Radue EW, Kappos L, Hartung HP, Hohlfeld R, Sandberg-Wollheim M, Kooijmans-Coutinho MF, Tsao EC, Sandrock AW and the European IFNß-1a (Avonex) Dose-Comparison Study Investigators (2002). A randomised, double-blind, dose-comparison study of weekly interferon ß-1a in relapsing MS. Neurology 59: 1507-1517

Derfuß T, Meinl E (2002). Herpesviral proteins blocking apoptosis. Viral Proteins Counteracting Host Defenses, Koszinowski/Hengel (ed.). Curr Topics Microbiol Immunol  269: 257-268

Farina C, Vargas V, Heydari N, Kümpfel T, Meinl E, Hohlfeld R (2002). Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients. J Neuroimmunol 123:188-192

Farina C, Wagenpfeil S, Hohlfeld R (2002). Immunological assay for assessing the efficacy of glatiramer acetate (Copaxone) in multiple sclerosis: A pilot study. J Neurol 249: 1587-1592

Gold R, Linington C (2002). Devic’s disease: bridging the gap between laboratory and clinic. Brain 125: 1425-1427

Hammer MH, Schroder G, Risch K, Flugel A, Volk HD, Lehmann M, Ritter T (2002). Antigen-dependent transgene expression in kidney transplantation: a novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol 13: 511-8

Hohlfeld R (2002). How promising is hematopoetic stem cell transplantation in multiple sclerosis? J Neurol 249: 1147-1149

Hohlfeld R (2002). Myelin failure in multiple sclerosis: Breaking the spell of Notch. Nat Med 8: 1075-1076

Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H (2002). Role of Lkb1, the causative gene of Peutz–Jegher’s syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 99: 8903-8908

Kirchhoff S, Sebens T, Baumann S, Krueger A, Zawatzky R, Li-Weber M, Meinl E, Neipel F, Fleckenstein B, Krammer PH (2002). Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter. J Immunol 168: 1226-1234

Klinkert WEF, Bode W, Jenne DE (2002). The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. Journal of Biol Chem 277(52): 50923-50933

Meinl E, Hohlfeld R (2002). Immunopathogenesis of Multiple Sclerosis: MBP and beyond. Clin Exp Immunol 128: 395-397

Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA (2002). Tumor necrosis factor inhibits outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. J Neurosci 22: 854-862

Oldstone, MBA, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R (2002). Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion. J Virol 76: 4357-4363

Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O´Connor P, Monaghan E, Li D, Weinshenker B, and the EVIDENCE Study Group and the University of British Columbia MS/MRI Research Group (2002). Randomized, comparative study of interferon ß-1a treatment regimes in MS: The EVIDENCE Trial. Neurology 59: 1496-1506

Popovic N, Schubart A, Goetz BD, Zhang SC, Linington C, Duncan ID (2002). Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol 51: 215-223

Scolding NJ, Wilson H, Hohlfeld R, Polman C, Leite I, Gilhus N (The EFNS Cerebral Vasculitis Task Force) (2002). The recognition, diagnosis and management of cerebral vascultitis: a European survey. Eur J Neurol 9: 343-347

Stadelmann C, Kerschensteiner M, Misgeld T, Brück W, Hohlfeld R, Lassmann H (2002). BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain 125: 75-85

Storch MK, Weissert R, Stefferl A, Birnbacher R, Wallstrom E, Dahlman I, Ostensson CG, Linington C, Olsson T, Lassmann H (2002). MHC gene related effects on microglia and macrophages in experimental autoimmune encephalomyelitis determine the extent of axonal injury. Brain Pathol 12: 287-299

Wekerle H (2002). Tackling multiple sclerosis. Nature 420: 39-40

Wekerle H (2002). Immune protection of the brain – efficient and delicate. J Infect Dis 186: 140-144

Wiendl H., Hohlfeld R. (2002). Therapeutic approaches in multiple sclerosis: Lessons from failed and interrupted treatment trials. Biodrugs 16: 183-2000

Wiendl H, Malotka J, Holzwarth B, Weltzien HU, Wekerle H, Hohlfeld R, Dornmair K (2002). An autoreactive gamma delta TCR derived from a polymyositis lesion. J Immunol 169: 515-521

Ziemssen T, Neuhaus O, Hohlfeld R (2002). Risk-benefit assessment of glatiramer acetate in multiple sclerosis. Drug safety 24: 979-990

Ziemssen T, Kümpfel T, Klinkert WEF, Neuhaus O, Hohlfeld R (2002). Glatiramer actate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain 125: 2381-2391

2001

Altare F, Ensser A, Breiman A, Reichenbach J, Baghdadi J E, Fischer A, Emile J F, Gaillard J L, Meinl E, Casanova J (2001). Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis. J Infect Dis 184: 231-236

Brünig I, Penschuck S, Berninger B, Benson J, Fritschy J M (2001). BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABAA receptor surface expression. Eur J Neurosci 13: 1320-1328

Bußhoff U, Hein A, Iglesias A, Dörries R, Régnier-Vigouroux A (2001). CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination. J Neuroimmunol 113: 220-230

Daubenberger C A, Nickel B, Hübner B, Siegler U, Meinl E, Pluschke G (2001). Herpesvirus saimiri transformed T cells and peripheral blood mononuclear cells restimulate identical antigen-specific human T cell clones. J Immunol Methods 254: 99-108

Derfuss T, Guerkov R, Then Bergh F, Goebels N, Hartmann M, Barz C, Wilske B, Autenrieth I, Wick M, Hohlfeld R, Meinl E (2001). Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 124: 1325-1333

Derfuss T, Hohlfeld R, Meinl,E (2001). Multiple Sklerose: Chlamydien-Hypothese in der Diskussion. Der Nervenarzt 72: 820-823

Egg R, Reindl M, Deisenhammer F, Linington C, Berger T (2001). Anti-MOG and anti-MBP antibody subclasses in multiple sclerosis. Mult Scler 7(5): 285-289

Farina C, Then Berg F, Albrecht H, Meinl E, Yassouridis A, Neuhaus O, Hohlfeld R (2001). Treatment of multiple sclerosis with Copaxone (COP). Elispot assay detects COP-induced interleukin-4 and interferon-g response in blood cells. Brain 124: 705-719

Flügel A, Hager G, Horvat A, Spitzer C, Singer G, Graeber M B, Kreutzberg, GW, Schwaiger W (2001). Neuronal MCP-1 expression in response to remote nerve injury. J Cereb Blood F Met 21: 69-76

Flügel A, Bradl M, Kreutzberg G W, Graeber, M B (2001). Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J Neurosci Res 66: 74-82

Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne D, Li Z, Ellwart J, Willem M, Wekerle H (2001). Migratory activity and functional changes of autoimmune T cells preceding and during experimental autoimmune encephalomyelitis: A study of genetically engineered green fluorescent effector cells. Immunity 14: 547-560

Flügel A, Bradl M (2001). New tools to trace populations of inflammatory cells in the CNS. Glia 36: 125-136

Flügel A, Matsumoru K, Neumann H, Klinkert WEF, Birnbacher R, Lassmann H, Otten U and Wekerle H (2001). Anti-inflammatory activity of nerve growth factor in experimental autoimmune encephalitis: inhibition of monocyte transendothelial migration. Eur J Immunol 31: 11-22

Haase C G, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, Schneidewind JM, Zettl UK, Heidenreich F, Berger T, Wekerle H, Hohlfeld R, Linington C (2001). The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J Neuroimmunol 114: 220-225

Hackstein H, Bitsch A, Bohnert A, Hofmann H, Weber F, Ohly A, Linington C, Mäurer M, Poser S, Rieckmann P, Bein G (2001). Analysis of interleukin-4 receptor a variants in multiple sclerosis. J Neuroimmunol 113: 240-248

Henning G, Kraft MS, Derfuss T, Pirzer R, de Saint-Basile G, Aversa G, Fleckenstein B, Meinl E (2001). Signaling lymphocytic activation molecule regulates T cellular cytotoxicity. Eur J Immunol 31: 2741-2750

Hohlfeld R, Wekerle H (2001). Immunological update on multiple sclerosis. Current Opin Neurol 14: 299-304

Hohlfeld R, Wiendl H (2001). The ups and downs of Multiple Sclerosis therapeutics. Ann Neurol 49: 281-284

Holz A, Brett K, Oldstone M B A (2001). Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes. J Clin Invest 108: 1749-1758

Iglesias A (2001). Maintenance and loss of self-tolerance in B cells. Springer Semin Immunopathol 23:351-366

Iglesias A, Bauer J, Litzenburger T, Schubart A, Linington C (2001). T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36: 220-234

Iglesias, A, Litzenburger T and Wekerle H (2001). Pathogenesis of Multiple Sclerosis - Tracking the elusive role of B lymphocytes In:Genes and viruses in multiple sclerosis. Eds: Hommes OR, Clanet M, Wekerle H. Elsevier Science, 1-8

Jenne DE, Tinschert S, Reimann H, Lasinger W, Thiel G, Kehrer-Sawatzki H (2001). Molecular characterization of breakpoint boundaries in NF1 patients with long range deletions. Am J Hum Gen 69: 516-527

Kornek B, Storch M K, Bauer J, Djamshidian A, Weissert R, Wallstroem E, Stefferl A, Zimprich F, Olsson T, Linington C, Schmidbauer M, Lassmann H (2001). Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 124: 1114-1124

Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A (2001). Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1ß. J Immunol 167: 1989-1995

Lassmann H, Wekerle H, Hickey WF, Antel, J (2001). Editorial. Glia 36: 117

Liblau R, Fontaine B, Baron-Van Evercooren A, Wekerle H, Lassmann, H (2001). Demyelinating diseases: From pathogenesis to repair strategies. Trends in Neurosci 24: 134-135

Medana I, Li Z, Flügel A, Tschopp J, Wekerle H, Neumann H (2001). FasL (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity. J Immunol 167(2): 674-81

Medana I, Martinique MMA, Wekerle H, Neumann H (2001). Transection of MHC class I-induced neuritis by cytotoxic T lymphocytes. Am J Pathol 159: 817-824

Meinl E, Derfuss T, Pirzer R, Blank N, Lengenfelder D, Blancher A, Le Deist F, Fleckenstein B, Hivroz C (2001). Herpesvirus saimiri replaces ZAP-70 for CD3 and CD2-mediated T cell activation. J Biol Chem 276: 36902-36908

Meinl E, Voltz R (2001). Immunologie des Demyelinisations- und Remyelinisationsprozesses. In: Multiple Sklerose, 3. Auflage. Editoren Schmidt R M, Hoffmann F, Urban & Fischer, 35-43

Neipel F, Meinl E (2001). Human Herpesvirus-8: Dysregulation of cell growth and apoptosis. Viruses, Cell Transformation and Cancer. RJA Grand, ed. AJ Zimmermann and I Mushahawar, series editors eds. Elsevier Amsterdam 291-308

Neuhaus O, Farina C, Wekerle H, Hohlfeld R (2001). Mechanisms of action of glatiramer acetate in multiple sclerosis. Neurology 56: 702-708

Neumann H (2001). Control of glial immune function by neurons. Glia 36: 191-199

Owens T, Wekerle H, Antel J (2001). Genetic models for CNS inflammation. Nat Med 7: 161-165

Patterson JB, Cornu TJ, Redwine J, Dales S, Lewicki H, Holz A, Thomas D, Billeter MA, Oldstone MBA (2001). Evidence that the hypermutated M protein of a subacute sclerosing panencephalitis measles virus actively co - atributes to the chronic progressive CNS disease. Virology 291: 215-225

Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernández-Klett F, Prass K, Bechmann I, de Boer BA, Frotscher M, Kreutzberg GW, Persons DA, Dirnagl U (2001). Targeting of gene-modified hematopoietic cells to the central nervous system: use of the green fluorescent protein uncovers microglial engraftment. Nat Med 7(1): 356-1361

Schmidt S, Haase C , Bezman L, Moser H, Schmidt M, Kohler W, Linington C, Klockgether T (2001). Serum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis. J Neuroimmunol 119(1): 88-94

Stefferl A, Storch MK, Linington C, Stadelmann C, Lassmann H, Pohl T, Holsboer F, Tilders FJH, Reul JMHM (2001). Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone. Endocrinology 142: 3616-3624

Sun D, Whitaker N J, Huang Z, Liu D, Coleclough C, Wekerle H, Raine CS (2001). Myelin antigen-specific CD8* T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 166: 7579-7587

Weissert R, de Graaf K L, Storch, M K, Barth S, Linington C, Lassmann H, Olsson T (2001). MHC class II-regulated Central Nervous System autoaggression and T cell responses in peripheral lymphoid tissues are dissociated in Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis. J Immunol 166: 7588-7599

Yang HAT, Bergsteinsdottir K, Wernhoff P, Linington C, Pettersson U Holmdahl R (2001). Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate. J Neuroimmunol 117: 21-29

2000

Bourquin C, Iglesias A, Berger T, Wekerle H, Linington C (2000). DNA vaccination induced autoaggression: Exacerbation of experimental autoimmune encephalitis (EAE) following DNA vaccination with myelin oligodendrocyte glycoprotein. Eur J Immunol 30: 3663-3671

Jenne DE, Tinschert S, Stegmann E, Reimann H, Nürnberg P, Horn D, Ilka Naumann I, Buske A and Thiel G (2000). A common set of at least 11 functional genes are lost in the majority of NF1 patients with gross deletions. Genomics 66: 93-97

Medana I, Gallimore A, Oxenius A, Martinic M, Wekerle H, Neumann H (2000). MHC class I-restricted killing of neurons by virus specific CD8+ T-lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur J Immunol 30: 3623-3633

Litzenburger T, Blüthmann H, Morales P, Pham-Dinh D, Dautigny A, Wekerle H, Iglesias A (2000). Development of MOG autoreactive transgenic B lymphocytes: Receptor editing in vivo following encounter of a self-antigen distinct from MOG. J Immunol 165: 5360-5366

Meinl E, Lengenfelder D, Blank N, Pirzer R, Barata L. Hivroz C (2000). Differential requirements of ZAP-70 for CD2-mediated pathways of mature human T cells. J Immunol 165: 3578-3583

Wiendl H, Behrens L, Maier S, Johnson MA, Weiss EH, Hohlfeld R (2000). Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G. Ann Neurol 48: 679-684

Neuhaus O, Farina C, Yassouridis A, Wiendl H, Bergh FT, Dose T, Wekerle H, Hohlfeld R (2000). Multiple sclerosis: Comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc Natl Acad Sci USA  97: 7452-7457

Flügel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, Kreutzberg GW, Gräber MB (2000). Neuronal FasL induces cell death of encephalitogenic T lymphocytes. Brain Pathol 10: 353-364

Moreira ES, Wiltshire TJ, Faulkner G, Nilforoushan A, Vainzof M, Suzuki O, Valle G, Reeves R, Zatz M, Passos-Bueno MR, Jenne DE (2000). Identification of the gene causing a novel form of limb-girdle muscular dystrophy. Nat Genet 24: 163-166

Hohlfeld R, Kerschensteiner M, Stadelmann C, Lassmann H, Wekerle H (2000). The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. J Neuroimmunol 107: 161-166

Goebels N, Hofstetter H, Schmidt S, Brunner C, Wekerle H, Hohlfeld R (2000). Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence. Brain 123(3): 508-518

Meinl E, Hohlfeld R (2000). T cell transformation with Herpesvirus saimiri: a tool for neuroimmunological research. J Neuroimmunol 103: 1-7

1999

Bradl, M, Bauer, J, Inomata, T, Zielasek, J, Nave, KA, Toyka, K, Lassmann, Wekerle, H (1999). Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis. Acta Neuropathol 97: 595-606

Padberg F, Matsuda M, Fenk R, Patenge N, Kubuschok, B, Hohlfeld R, Wekerle H, Spuler, S (1999). Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures. Eur J Immunol 29: 3538-3548

Fernández-Miguel G, Alarcón B, Iglesias A, Blüthmann H, Alvarez-Mon, Sanz E, de la Hera A (1999). Multivalent structure of an abT cell receptor. Proc Nat Acad Sci USA 96: 1547-1552

Meinl, E (1999). Concepts of viral pathogenesis of multiple sclerosis. Curr Opin Neurol 12: 303-307

Wilharm E, Parry MAA, Friebel R, Tschesche H, Matschiner G, Sommerhoff CP, Jenne DE (1999). Generation of catalytically active granzyme K form E. coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma. J Biol Chem 274: 27331-27337

Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R (1999). Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 122: 2089-2100

Brehm U, Piddlesden SJ, Gardinier MV, Linington C (1999). Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG). J Neuroimmunol 97: 9-15

Flügel A, Willem M, Berkowicz T, Wekerle H (1999). Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat Med 5: 843-847

Stefferl A, Brehm U, Storch M, Lambracht-Washington D, Bourquin C, Wonigeit K, Lassmann H, Linington C (1999). Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. J Immunol 163: 40-49

Friedl W, Kruse R, Uhlhaas S, Stolte M, Keller KM, Jungck M, Stern M, Loff S, Back W, Propping P, Jenne DE (1999). Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients. Gene Chromosome Canc 25: 403-406

Kerschensteiner M, Gallmeier E, Behrens L, Leal VV, Misgeld T, Klinkert WE, Kolbeck R, Hoppe E, Oropeza-Wekerle RL, Bartke I, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999). Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189: 865-870

Weerth S, Berger T, Lassmann H, Linington C (1999). Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat. J Neuroimmunol 95: 157-164

Wekerle H (1999). Remembering MOG: autoantibody mediated demyelination in multiple sclerosis? Nat Med 5: 153-154

Stefferl A, Linington C, Holsboer F, Reul JM (1999). Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat. Endocrinology 140: 4932-4938

Wong ETL, Jenne DE, Porter SD, Gilks CB (1999). Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation. Blood 94: 3730-3736

1998

Wekerle H (1998). The viral triggering of autoimmune disease. Nat Med 4: 770-771

Behrens L, Kerschensteiner M, Misgeld T, Goebels N, Wekerle H, Hohlfeld R (1998). Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions [published erratum appears in J Immunol 2000 May 15;164(10):5330]. J Immunol 161: 5943-5951

Schwaeble WJ, Stover CM, Schall TJ, Dairaghi, DJ, Trinder PKE, Linington C, Iglesias A, Schubart A, Lynch NJ, Weihe E, Schäfer MKH (1998). Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Letters 439: 203-207

Wekerle H (1998). Immune pathogenesis of multiple sclerosis. Brain autoimmune reactivity and its control by neuronal function. Mult Scler 4: 136-137

Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender, Giegerich, G, de Waal M, Wekerle H, Hohlfeld R (1998). Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis. Brain 121: 1395-1407

Litzenburger T, Fässler R., Bauer J, Lassmann H, Linington C, Wekerle, Iglesias A (1998). B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med 188: 169-180

Neumann H, Misgeld T, Matsumuro K, Wekerle H (1998). Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Nat Acad Sci USA 95: 5779-5784

Bender A, Behrens L, Engel AG, Hohlfeld R (1998). T-cell heterogeneity in muscle lesions of inclusion body myositis. J Neuroimmunol 84: 86-91

Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller D, Back W, Zimmer (1998). M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 18: 38-44

Kaab G, Haarmann I, Wekerle H, Bradl M (1998).The myelin basic protein-specific T cell repertoire in Lewis rats: T cell receptor diversity is influenced both by intrathymic milieu and by extrathymic peptide presentation. Eur J Immunol 28: 1499-1506

Neumann H, Wekerle H (1998). Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. J Neuropath Exp Neur 57: 1-9

1997

Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H (1997). Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med 186: 2023-2031

Hohlfeld R, Engel AG, Goebels N, Behrens L (1997). Cellular immune mechanisms in inflammatory myopathies. Curr Opin Rheum 9: 520-526

Voltz RD, Albrich WC, Nagele A, Schumm F, Wick M, Freiburg A, Gautel, Thaler, HT, Aarli J, Kirchner T, Hohlfeld R (1997). Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. Neurology 49: 1454-1457

Kojima K, Wekerle H, Lassmann H, Berger T, Linington C (1997). Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta. J Neural Trans Supplementum. 49: 43-51

Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal M, Wekerle H, Hohlfeld R (1997). Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis. Brain 120: 1437-1445

Kojima K, Reindl M, Lassmann H, Wekerle H,  Linington C (1997). The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus. Int Immunol 9: 897-904

Behrens L, Bender A, Johnson MA, Hohlfeld R (1997). Cytotoxic mechanisms in inflammatory myopathies. Co-expression of Fas and protective Bcl-2 in muscle fibres and inflammatory cells. Brain 120: 929-938

Hohlfeld R (1997). Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives. Brain 120: 865-916

Liu X, Linnington C, Webster HD, Lassmann S, Yao DL, Hudson LD, Wekerle H, Kreutzberg GW (1997). Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis. J Neurosci Res 47: 531-538

Berger T, Weerth S, Kojima K, Linington C, Wekerle H, Lassmann H (1997). Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Lab Invest 76: 355-364

Meinl E, Fickenscher H, Hoch RM, Malefyt RD, de Waal M, Hart BA, Wekerle H, Hohlfeld R, Fleckenstein B (1997). Growth transformation of antigen-specific T cell lines from rhesus monkeys by herpesvirus saimiri. Virology 229: 175-182

Klinkert WE, Kojima K, Lesslauer W, Rinner W, Lassmann H, Wekerle H (1997). TNF-alpha receptor fusion protein prevents experimental auto-immune encephalomyelitis and demyelination in Lewis rats: an overview. J Neuroimmunol 72: 163-168

Meinl E, Hoch RM, Dornmair K, de Waal M, Bontrop RE, Jonker, Lassmann H, Hohlfeld R, Wekerle H,  't, HB (1997). Encephalitogenic potential of myelin basic protein-specific T cells isolated from normal rhesus macaques. Am J Pathol 150: 445-453

Neumann H, Schmidt H, Cavalie A, Jenne DE, Wekerle H (1997). Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 185

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