Publications
Publication list up until the year 2017.
2017
Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld H, Krishnamoorthy G, Wekerle H (2017). Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. PNAS, doi: 10.1073/pnas.1711233114
Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N (2017). Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. PNAS, doi: 10.1073/pnas.1701806114
Wekerle H (2017). Brain Autoimmunity and Intestinal Microbiota: 100 Trillion Game Changers. Trends Immunol 38(7): 483-497
Wekerle H (2017). B Cells in Multiple Sclerosis. Autoimmunity 50(1): 57-60
2016
Wekerle H (2016). The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria. Rheumatology 55(suppl2):ii68-ii75 (invited review)
Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch , Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K (2016). Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. PNAS 113(28): 7864-7869
Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2016). The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol 15: 198-209
Hohlfeld R, Dornmair K, Meinl E, Wekerle H (2016). The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurol 15: 317-331
2015
Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M (2015). Deficiency of the Stroke Relevant Hdac9 Gene Attenuates Atherosclerosis in Accord with Allele-Specific Effects at 7p21.1. Stroke 46(1):197-202, doi: 10.1161/STROKEAHA.114.007213. Epub 2014 Nov 11
Rumble JM, Huber AK, Krishnamoorthy G, Srinivasan A, Giles DA, Zhang X, Wang L, Segal BM (2015). Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med 212:23-35
Wekerle H (2015). Nature plus nurture: the triggering of multiple sclerosis. Swiss Med Wkly 145: w14189, doi: 10.4414/smw.2015.14189
Wekerle H (2015). Vaccination and narcolepsy: Immune link found? Sci Transl Med 7(294):294fs27, doi: 10.1126/scitranslmed.aac7091
Hohlfeld R, Wekerle H (2015). Multiple sclerosis and microbiota. From genome to metagenome? Nervenarzt 86(8):925-33, doi: 10.1007/s00115-014-4248-7
Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rübsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E (2015). γ-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun 6:7333, doi: 10.1038/ncomms8333
Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K (2015). αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm 2(4):e107, doi: 10.1212/NXI.0000000000000107. eCollection 2015
Nicol B, Salou M, Laplaud DA, Wekerle H (2015). The autoimmune concept of multiple sclerosis. Presse Med 44(4 Pt 2):e103-12, doi: 10.1016/j.lpm.2015.02.009. Epub 2015 Mar 23
2014
Koutrolos M, Berer K, Kawakami N, Wekerle H, Krishnamoorthy G (2014). Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS, Acta Neuropathol Commun 2: 163
Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, Meinl E (2014). Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination, Acta Neuropathol Commun 2(1):178
Ben-Nun A, Kaushansky N, Kawakami N, Krishnamoorthy G, Berer K, Liblau R, Hohlfeld R, Wekerle H (2014). From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development. J Autoimmun S0896-8411(14) 00101-2, doi: 10.1016/j.jaut.2014.06.004
Eberle M, Ebel P, Wegner MS, Männich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, Geisslinger G, Grösch S, Schiffmann S (2014). Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. Biochem Pharmacol 92: 326-335
Berer K, Boziki M, Krishnamoorthy G (2014). Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS ONE 9(2): e87876
Nischwitz S, Faber H, Sämann PG, Domingues HS, Krishnamoorthy G, Knop M, Müller-Sarnowski F, Yassouridis A, Weber F (2014). Interferon beta-1a reduces increased interleukin-16 levels in MS patients. Acta Neurol Scand 130: 46-52
Berer K, Krishnamoorthy G (2014). Microbial view of central nervous system autoimmunity. FEBS Letters 588: 4207–4213, doi: 10.1016/j.febslet.2014.04.007
Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, Kovalchuk Y, Liang Y, Kalamakis G, Laukat Y, Becker S, Witte G, Geiger A, Allen T, Rome LC, Chen TW, Kim DS, Garaschuk O, Griesinger C, Griesbeck O (2014). Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes. Nat Methods 11(2): 175-182
2013
Wekerle H (2013). Tissue Hypoxia in Autoimmune Brain Disease: A Columbian Discovery? Ann Neurol 74(6): 765-767
Wekerle H, Berer K, Krishnamoorthy G (2013). Remote control - triggering of brain autoimmune disease in the gut. Curr Opin Immunol 25: 1-7
Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CCA, Shlomchik MJ, Zamvil SS (2013). MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med 210(13): 2921-2937
Wekerle H, Meinl E (2013). Multiple sclerosis: An old drug plays a new trick (News and Views). Nature 502: 314-315
Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostásy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Pröbstel AK, Dornmair K, Wekerle H, Hohlfeld , Banwell B, Bar-Or A, Meinl E (2013). Distinction and Temporal Stability of Conformational Epitopes on Myelin Oligodendrocyte Glycoprotein Recognized by Patients with Different Inflammatory Central Nervous System Diseases. J Immunol 191(7): 3594-604
Neumann H, Wekerle H (2013). Brain microglia: Watchdogs with pedigree (News and Views). Nat Neurosci 16(3): 253-255
Mues M, Bartholomäus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G (2013). Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nat Med 19(6):778-784
Pesic M, Bartholomäus I, Kyratsous NI, Heissmeyer V, Wekerle H, Kawakami N (2013). 2-photon imaging of phagocyte-mediated T cell activation in the CNS. J Clin Invest 123(3): 1192–1201
Pohl M, Kawakami N, Kitic M, Bauer J, Martins R, Fischer MT, Machado-Santos J, Mader S, Ellwart JW, Misu T, Fujihara K, Wekerle H, Reindl M, Lassmann H, Bradl M. (2013). T cell-activation in neuromyelitis optica lesions plays a role in their formation. Acta Neuropathol Commun 1: 85
Pesic M, Kawakami N, Bartholomäus I, Kyratsous NI (2013). Imaging of Immune Cell Behavior and Function in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Clin Exp Neuroimmunol 4 (Suppl. 1): 27–35
Kawakami N, Bartholomäus I, Pesic M, Kyratsous NI (2013). Intravital imaging of autoreactive T cells in living animals. Methods Cell Biol 113:149-68
2012
Berer K, Krishnamoorthy G (2012). Commensal gut flora and brain autoimmunity: a love or hate affair? Acta Neuropathol 123(5): 639-51, doi: 10.1007/s00401-012-0949-9
Hohlfeld R (2012). Ion channels boost axonal injury in multiple sclerosis. Nat Med 18: 1743-1745
Direnberger S, Mues M, Micale V, Wotjak CT, Dietzel S, Schubert M, Scharr A, Hassan S, Wahl-Schott C, Biel M, Krishnamoorthy G, Griesbeck O (2012). Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model. Nat Comm 3: 1031
Kawakami N, Bartholomäus I, Pesic M, Mues M (2012). An autoimmunity odyssey: how autoreactive T cells infiltrate into the CNS. Immunol Rev 248(1): 140-55
Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WEF, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A (2012). T cells become licensed in the lung to enter the central nervous system. Nature 488: 675-679
Siewert K, Malotka J, Kawakami N, Wekerle H, Hohlfeld R, Dornmair K (2012). Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nat Med 18: 824-829
Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada L, Medico E, Hohlfeld R, Meinl E, Farina C (2012). Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med 209: 521-535
Wekerle H, Flügel A, Fugger L, Schett G, Serreze DV (2012). Autoimmunity's next top models. Nat Med 18: 66-70
Wekerle H, Krishnamoorthy G (2012). Brain autoimmunity: The CD8 question(s). Immunity 37: 1, 8-10
Hohlfeld R, Wekerle H (2012). β-Amyloid: Enemy or Remedy? Sci Translat Med 4: 145fs24
Elliott C, Lindner M, Arthur A, Brennan K, Jarius S, Hussey J, Chan A, Stroet A, Olsson T, Willison H, Barnett SC, Meinl E, Linington C (2012). Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 135: 1819-1833
Bruder J, Siewert K, Obermeier B, Malotka J, Scheinert P, Kellermann J, Ueda T, Hohlfeld R, Dornmair K (2012). Target specificity of an autoreactive γδ-T cell receptor in myositis. J Biol Chem 287: 20986-95
Ng JK, Malotka J, Kawakami N, Derfuss T, Khademi M, Olsson T, Linington C, Odaka M, Tackenberg B, Prüss H, Schwab JM, Harms L, Harms H, Sommer C, Rasband MN, Eshed-Eisenbach Y, Peles E, Hohlfeld R, Yuki N, Dornmair K, Meinl E (2012). Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology 79(23): 2241-2248, doi: 10.1212/WNL.0b013e31827689ad. Epub 2012 Oct 24.
Meinl E, Meister G (2012). MicroRNAs in the CSF: Macro-advance in MS? Neurology, 79(22): 2162-2163, Epub 2012 Oct 17.
Eisele S, Krumbholz M, Fischer MT, Mohan H, Junker A, Arzberger T, Hohlfeld R, Bradl M, Lassmann H, Meinl E (2012). Prospects of transcript profiling for mRNAs and micro RNAs using formalin fixed and paraffin embedded dissected autoptic multiple sclerosis lesions. Brain Pathol 22: 607-618
Kim SM, Bhonsle L, Besgen P, Nickel J, Vollmer S, Backes A, Held K, Vollmer S, Dornmair K, Prinz JC (2012). Analysis of the paired TCR α- and β-chains of single human T cells. PLoS ONE 7(5): e37338
Krumbholz M, Derfuss T, Hohlfeld R, Meinl E (2012). B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol 8(6): 13-623
Derfuss T, Meinl E (2012). Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment? Curr Opin Neurol 25: 231-238
Mayer MC, Hohlfeld R, Meinl E (2012). Viability of autoantibody-targets: how to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis. J Neurol Sci 319: 2-7
Mayer MC, Meinl E (2012). Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Ther Adv Neurol Disord 5: 147-159
Lippok S, Seidel SAI, Duhr S, Uhland K,Holthoff HP, Jenne D, Braun D (2012). Direct Detection of Antibody Concentration and Affinity in Human Serum Using Microscale Thermophoresis, Anal Chem 84(8): 3523-3530, doi: 10.1021/ac202923j
Hedberg C, Melberg A, Kuhl A, Jenne D, Oldfors A (2012). Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation, Eur J Hum Genet 20(9): 984-985, doi: 10.1038/ejhg.2012.39
Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE (2012). NSP4, an elastase-related protease in human neutrophils with arginine specificity, Proc Natl Acad Sci USA 109(16): 6229-6234, doi: 10.1073/pnas.1200470109
Mankan AK, Dau T, Jenne D, Hornung V (2012). The NLRP3/ASC/Caspase-1 axis regulates IL-1 ss processing in neutrophils, Eur J Immunol 4(3): 710-717, doi: 10.1002/eji.201141921
2011
Berer K, Mues M, Koutroulos M, Al Rasbi Z, Boziki M, Johner C, Wekerle H, Krishnamoorthy G (2011). Commensal microbiota and myelin autoantigen cooperate to trigger T/B cell mediated spontaneous EAE, a model for relapsing-remitting multiple sclerosis. Nature 479: 538-541
Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T (2011). Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J Virol 85(19): 9680-5
Pellkofer HL, Krumbholz M, Berthele A, Hemmer B, Gerdes LA, Havla J, Bittner R, Canis M, Meinl E, Hohlfeld R, Kuempfel T (2011). Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Neurology 76(15): 1310-5
Ivanidze J, Hoffmann R, Lochmüller H, Engel AG, Hohlfeld, R*, Dornmair K* (2011). Inclusion Body Myositis: Laser microdissection reveals differential upregulation of IFN gamma signaling cascade in attacked versus non-attacked myofibers. Am J Pathol 179: 1347-1359
Junker A, Hohlfeld R, Meinl E (2011). The emerging role of microRNAs in multiple sclerosis. Nat Rev Neurol 7: 56-59
Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forne I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B*, Bar-Or A*, Meinl E*, Derfuss T* (2011) Antobodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology 77(6):580-8, * equal contribution
Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM (2011). Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology 140(4): 1272-82
Croker BA, Lewis RS, Babon JJ, Mintern JD, Jenne DE, Metcalf D, Zhang JG, Cengia LH, O'Donnell JA, Roberts AW (2011). Neurotophils require SHP1 to regulate IL-1β production and prevent inflammatory skin disease. J Immunol 186(2): 1131-9
Fitzner D, Schnaars M, van Rossum D, Krishnamoorthy G, Dibaj P, Bakhti M, Regen T, Hanisch UK, Simons M (2011). Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci 124: 447-458
Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K (2011). Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol 233: 245-248
Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A (2011). Highly skewed T- cell receptor V beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal 1, doi:10.1038/bcj.2011.6.
Berer K, Wekerle H, Krishnamoorthy G (2011). B cells in spontaneous autoimmune diseases of the central nervous system. Mol Immunol 48: 1332-1337
Kessenbrock K, Dau T, Jenne DE (2011). Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med 89: 23-28
Varadarajulu J, Lebar M, Krishnamoorthy G, Habelt S, Lu J, Bernard WI, Li H, Holsboer F, Turck CW, Touma, C (2011). Increased anxiety-related behaviour in Hint1 knockout mice. Behav Brain Res 220: 305-311
2010
Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G (2010). Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis. PLOS ONE 5(11): e15531
Silva F, Hummel AM, Jenne DE, Specks U (2010). Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's, J Autoimmun 35(4): 299-308
Korkmaz B, Horwitz MS, Jenne DE, Gauthier F (2010). Neutrophil elastase, proteinase 3 and cathepsin G as therapeutic targets in human diseases, Pharmacol Rev 62(4): 726-59
Kawakami N, Flügel A (2010). Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Semin Immunopathol 32: 275-287
Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A (2010). Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133: 1930-1943
Kurschus FC, Jenne DE (2010) .Delivery and therapeutic potential of human Granzyme B. Immunological Rev 235: 159-171
Kuhl A, Korkmaz B, Utecht B, Kniepert A, Schönermarck U, Specks U, Jenne DE (2010). Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener’s granulomatosis. J Immunology, 185: 387-399
Mohan H, Krumbholz M, Sharma R, Eisele S, Junker A, Sixt M, Newcombe J, Wekerle H, Hohlfeld R, Lassmann H, Meinl E (2010). Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are up-regulated and associated with infiltrating immune cells. Brain Pathol 20: 966-975
Wekerle H and Hohlfeld R (2010). Molecular oracles for multiple sclerosis therapy. Nat Med 16(4): 376-377
Wekerle H and Hohlfeld R (2010). Zero tolerance (to AChR) and ways to overcome it. Ann Neurol 67(4): 422-424
2009
Dornmair K, Meinl E, Hohlfeld R (2009). Novel approaches for identifying target antigens of autoreactive human B and T cells. Semin Immunopathol 31: 467-477
Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, Lassmann H, Wekerle H, Hohlfeld R, Meinl E (2009). MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47, Brain 132: 3342-3352
Bartholomäus I*, Kawakami N*, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, Klinkert WEF, Flügel-Koch C, Issekutz TB, Wekerle H, Flügel A (2009). Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 462(7269): 94-98, * Co-first authors
Krishnamoorthy G, Saxena A, Mars LT, Domingues H.S, Mentele R, Ben-Nun A, Lassmann H, Dornmair K, Kurschus FC, Liblau R, Wekerle H (2009). Myelin specific T cells co-recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med 15(6): 626-632
Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE (2009). Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15(6): 623-625
Pöllinger B, Krishnamoorthy G, Berer K, Lassmann H, Bösl M, Dunn R, Domingues HS, Holz A, Kurschus FC, Wekerle H (2009). Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit MOG-specific endogenous B cells. J Exp Med 206(6): 1303-1316
Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Flügel A, Dockery P, O’Brie T, Howard L, Windebank AJ, Barry FP (2009). Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without diff erentiating into neural cells. Tissue Eng Part A 15(10): 3049-59
Schwab N, Bien CG, Waschbisch A, Becker A, Vince, GH, Dornmair K, Wiendl H (2009). CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132: 1236-1246
Pellkofer HL, Voltz R, Goebels N, Hohlfeld R, Dornmair K (2009). Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol 66(5): 655-658
Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C, Meinl E (2009). Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci USA 106: 8302-8307
Kurschus F, Paramita Pal P, Bäumler P, Jenne DE, Wiltschi B, Budisa N (2009). Gold fluorescent annexin A5 as a novel apoptosis detection tool. Cytometry, 75A: 626-633
Romero V, Fellows E, Jenne DE, Andrade F (2009). Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity. Cell Death Differ 16(2): 340-348
Hohlfeld R (2009). Multiple sclerosis: Human model for EAE? Eur J Immunol 39(8): 2036-2039
Krishnamoorthy G, Wekerle H (2009). EAE: An immunologist’s Magic Eye. Eur J Immunol 39(8): 2031-2035
Kerschensteiner M, Meinl E, Hohlfeld R (2009). Neuro-immune crosstalk in CNS diseases. Neuroscience 158(3): 1122-1132
Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T (2009). Nonfunctional regulatory T cells and defective control of Th2-cytokine production in natural scurfy mutant mice. J Immunol 183: 5662-5672
2008
Korkmaz B, Kuhl A, Bayat B, Santoso S, Jenne DE (2008). A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. J Biol Chem 283(51): 5976-82, Epub 2008 Oct 14
Obermeier B, Mentele R, Malotka J, Kellermann J, Kümpfel T, Wekerle H, Lottspeich F, Hohlfeld R, Dornmair K (2008). Matching of oligoclonal Ig transcripts and proteins of cerebrospinal fluid in multiple sclerosis. Nat Med 14: 688-693
Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE (2008). Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest 118(7): 2438-47
Kurschus FC, Fellows E, Stegmann E, Jenne DE (2008). Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate dependent endocytosis. Proc Natl Acad Sci USA 105: 13799-13804
Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne DE, Holak TA, Werb Z, Sixt M, Wedlich-Söldner R (2008). Lifeact: a versatile marker to visualize F-actin. Nat Methods 5(7): 605-7
Deininger K, Eder M, Kramer E, Zieglgänsberger W, Dodt HU, Dornmair K, Colicelli J, Klein R (2008). The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci USA 105: 12539-12544
Krumbholz M*, Faber H*, Steinmeyer F, Hoffmann LA, Kümpfel T, Pellkofer H, Derfuss T, Ionescu C, Starck M, Hafner C, Hohlfeld R, Meinl E (2008). Interferon-ß increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 131: 1455-1463, * equal contribution
Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM (2008). CD28 superagonistic antibodies elicit two functionally distinct waves of T cell activation. J Clin Invest 118(4): 1405-1416
Matheu MP, Beeton C, Garcia A, Uemura MI, Li D, Pal S, de la Maza LM, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD (2008). In situ imaging of effector/memory. T cells during DTH and suppression by Kv1.3 channel block. Immunity 29: 602–614
Berzi A, Ayata CK, Cavalcante P, Falcone C, Candiago E, Motta T, Bernasconi P, Hohlfeld R, Mantegazza R, Meinl E*, Farina C* (2008). BDNF and its receptors in human myasthenic thymus: Implications for cell fate in thymic pathology. J Neuroimmunol 197: 128-139, *equal contribution
Obermeier B, Mentele R, Malotka J, Dornmair K (2008). Analysis of patient-specific immunoglobulin proteomes and transcriptomes by PCR cloning and mass spectrometry. Nat Protoc, doi: 10.1038/nprot.2008.87
Hohlfeld R, Meinl E, Dornmair K (2008). B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights. J Neurol Sci 274(1-2): 5-8
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2007
Mathey EK*, Derfuss T*, Storch MK, Williams KR, Hales K, Woolley DR, Al-Hayani A, Davies SN, Rasband M, Velhin S, Olsson T, Moldenhauer A, Hohlfeld R, Meinl E*, Linington C* (2007). Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med 204: 2363-2372, * contributed equally
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Jenne DE, Aries PM, Einwächter S, Akkad AD, Wieczorek S, Lamprecht P, Gross WL (2007). The low-penetrance R92Q mutation of the tumour necrosis factor superfamily 1A gene is neither a major risk factor for Wegener's granulomatosis nor multiple sclerosis. An Rheum Dis 66: 1266-1267
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2006
Seitz S, Schneider CK, Malotka J, Nong X, Engel, AG, Wekerle H, Hohlfeld R, and Dornmair K (2006). Reconstitution of paired T cell receptor α- and β-chains from microdissected single cells of frozen human tissues. Proc Natl Acad Sci USA 103: 12057-12062
Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang L, Potter BVL, Guse AH (2006). Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. Brit J Pharmacol 149(4): 337-44
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2005
Flügel A, Kawakami N (2005). Immune processes in the light of Two-photon microscopy. In “Leukocyte Trafficking” (A Hamann, Engelhardt B eds.) Wiley-VCH, pp 472-496
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Zagrebelsky M, Holz A, Dechant G, Barde Y A, Bonhoeffer T and Korte M (2005). The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons. J Neuroscie 25(43): 9989-9999
Wiesner O, Litwiller RD, Hummel AM, Viss MA, McDonald CJ, Jenne DE, Fass DN, Specks U (2005). Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments. FEBS Letters 579(24): 5305-5312
Farina C, Weber MS, Meinl E, Wekerle H, Hohlfeld R (2005). Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurol 4(9): 567-575
Spiegel M, Oexle K, Horn D, Windt E, Buske A, Albrecht B, Prott EC, Seemanova E, Seidel J, Rosenbaum T, Jenne DE, Kehrer-Sawatzki HK, Tinschert S (2005). Childhood overgrowth in patients with common NF1 microdeletions. Eur J Hum Genet 13(7): 883-888
Ziemssen T, Kümpfel T, Schneider H, Klinkert WEF, Neuhaus O, Hohlfeld R (2005). Secretion of brain-derived neurotrophic factor by glatiramer acetate-reactive T-helper cell lines: Implications for multiple sclerosis therapy. J Neurol Sci 233(1-2): 109-112
Bradl M, Bauer J, Flügel A, Wekerle H and Lassmann H (2005). Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. Am J Pathol 166(5): 1441-1450
Derfuss T, Hohlfeld R and Meinl E (2005). Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B-cell response. J Neurol 252(8): 968-971
Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, and Flügel A (2005a). Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med 201(11): 1805-1814
Krumbholz M, Theil D, Derfuss T, Rosenwald A, Schrader F, Monoranu C-M, Kalled SL, Hess DM, Serafini S, Aloisi F, Wekerle H Hohlfeld R, Meinl E (2005). BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med 201(2): 195-200
Kawakami N, Odoardi F, Ziemssen T, Bradl M, Ritter T, Neuhaus O, Lassmann H, Wekerle H, Flügel A (2005). Autoimmune CD4+ T Cell Memory: Lifelong Persistence of Encephalitogenic T Cell Clones in Healthy Immune Repertoires. J Immunol 175(1): 69-81
Vargas-Leal V, Bruno R, Derfuss T, Krumbholz M, Hohlfeld R, Meinl E (2005). Expression and function of glial cell line-derived neurotrophic factor (GDNF) family ligands and their receptors on human immune cells. J Immunol 175: 2301-2308
Kurschus FC, Bruno R, Fellows E, Falk CS, Jenne DE (2005). Membrane receptors are not required to deliver granzyme B during killer cell attack. Blood 105(5): 2049-58
Schmid C, Diem H, Herrman K, Voltz R, Ott G and Hallek M (2005). Central neurogenic hyperventilation as complication of Richter's syndrome. J Clin Oncol 23(9): 2096-2098
Wiendl H, Hohlfeld R, and Kieseier BC (2005). Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends Immunol 26(7):373-80
Jenne DE, Kley RA, Vorgerd M, Schröder JM, Weis J, Reimann H, Albrecht B, Nürnberg P, Thiele H, Müller CR, Meng G, Witt C, Labeit S (2005). Limb girdle muscular dystrophy in a sibling pair with a homozygous Ser606Leu mutation in the alternatively spliced IS2 region of calpain 3. Biol Chem 386: 61-67
Theil D , Farina C, Meinl E (2005). Differential expression of CD150 (SLAM) on monocytes and macrophages in chronic inflammatory contexts: Abundant in Crohn’s disease, but not in multiple sclerosis. J Clin Pathol 58: 110-111
Wekerle H (2005). Planting and pruning in the brain: MHC antigens involved in synaptic plasticity? Proc Natl Acad Sci USA 102 (Editorial)
Farina C, Krumbholz M, Giese T, Hartmann G, Aloisi F, Meinl E (2005). Preferential expression and function of Toll-like Receptor 3 in human astrocytes. J Neuroimmunol 159(1-2): 12-19
2004
Kawakami N, Lassmann S, Li ZX, Odoardi F, Ritter T, Ziemssen T, Klinkert WEF, Ellwart JW, Bradl M, Krivacic K, Lassmann H, Ransohoff RM, Volk HD, Wekerle H, Linington C, Flügel A (2004). The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med 199(2): 185-197
Skulina C, Schmidt S, Dornmair K, Babbe H, Roers A, Rajewsky K, Wekerle H, Hohlfeld R , Goebels N (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci USA 101(8): 2428-2433
Weber MS, Starck M, Wagenpfeil S, Meinl E, Hohlfeld, Farina C (2004). Glatiramer Acetate inhibits monocyte reactivity in vitro and in vivo. Brain 127: 1370-1378
Pfister H, Ollert M, Fröhlich LO, Quintanilla-Fend L, Colby TV, Specks U, Jenne, DE (2004). Autoantibodies against the murine homolog of Wegener’s autoantigen (proteinase 3) are pathogenic in vivo. Blood 104: 1411-1418
Kehrer-Sawatzki H, Kluwe L, Sandig C, Kohn M, Wimmer K, Krammer U, Peyrl A, Jenne DE, Hansmann I, Mautner VF (2004). High frequency of mosaicism among NF1 patients with large deletions in 17q11.2 caused by somatic recombination of the JJAZ1 gene. Am J Hum Genet 75: 410-423
Pellkofer H, Schubart AS, Höftberger R, Schutze N, Pagany M, Schüller M, Lassmann H, Hohlfeld R, Voltz R and Linington C (2004). Modeling paraneoplastic disease: Onconeuronal antigen specific T cells mediate autoimmune encephalomyelitis in the rat. Brain 127: 1822-1830
Linke R, Schröder M , Helmberger T, Voltz R (2004). Antibody-positive paraneoplastic neuroligical syndromes: The value of CT and FDG-PET imaging for tumor diagnosis. Neurology 63(2): 282-286
Wiesner O, Russell KA , Lee AS, Jenne DE , Trimarchi M, Gregorini G and Specks U (2004). Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase: a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Arthritis Rheum 50(9):2 954-2965
Mead R J, Neal JW, Griffiths M R, Linington C , Botto M, Lassmann H, Morgan BP (2004). Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest 84(1): 21-28
Scheid R, Lincke T, Voltz R, Cramon von DY (2004). Serial FDG-PET and MR-imaging of paraneoplastic limbic encephalitis. Arch Neurol 61(11): 1785-1789
Kurschus FC, Kleinschmidt M, Fellows E, Dornmair K, Rudolph R, Lilie H, Jenne DE (2004). Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett. 562(1-3): 87-92
Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R (2004). Fast dissociation kinetics of an autoreactive human Vγ1.3Vδ2 T-cell receptor/antigen complex. J Neuroimmunol 152: 168-175
Farina C, Theil D, Semlinger B, Hohlfeld R, Meinl E (2004). Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines. Internat Immunol 16: 799-809
Flügel A (2004). Gentransfer in Antigen-spezifischen CD4+ T-Zellen: Schicksal und Funktion autoreaktiver T-Zellen im Organismus. Ludwig-Maximilians-Universität München
Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J , Sillevis Smitt P, Vedeler C, Verschuuren JJGM, Vincent A, Voltz R (2004). For the Paraneoplastic Neurological Syndrome Euronetwork. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiat 75(8): 1135-1140
Karrasch T, Weil M, Voltz R, Schulz C, Audebert F, Woenckhaus M, Hofstadter F, Bogdahn U, Schölmerich J, Schaffler A, Steinbrecher A (2004). "Fußkribbeln", Vergesslichkeit und progrediente Wesensveränderung bei einer 63-jährigen Patientin. Internist 45(3): 341-346
Moser CM, Jenne DE, Pfister H, Ollert M, Krombach F (2004). Leukocyte migration in proteinase-3/elastase-2 double mutant mice in vivo. J Vasc Res 41(1): 94-95
Vargas V (2004). Expression and function of GDNF family ligands and their receptors by human immune cells. Ludwig-Maximilians-Universität München
Voltz R, Starck M, Zingler V, Strupp M and Kolb HJ (2004). Mitoxantrone therapy in multiple sclerosis and acute leukaemia: A case report out of 644 treated patients. Multiple Sclerosis 10: 472-474
Hohlfeld R, Wekerle H (2004). Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines (Review) Proc. Natl Acad Sci USA 101 (Suppl. 2): 14599-14606
Ziemssen T (2004). Neuroprotection and glatiramer acetate: The possible role in the treatment of Multiple Sclerosis. Front Clin Neurosci Neurodegeneration and Neuroprotection 541: 111-134
Hohlfeld R (2004). Immunologic factors in primary progressive multiple sclerosis. Mult Scler 10: S16-S22
Jenne DE (2004). Peutz-Jeghers Syndrome. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (edited by K. Ruckpaul and Detlev Ganten) Springer Verlag.
Meinl E, Voltz R (2004). Biomarker in der Therapie der Multiplen Sklerose: Läßt sich der Erfolg bald vorhersagen? MMW-Fortschr Med Sonderheft 2: 57-58
2003
Hink-Schauer C, Estébanez-Perpiñá EE, Kurschus FC, Bode W, Jenne DE (2003). Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat Struct Biol 10: 535-540
Hofbauer M, Wiesener S, Babbe H, Roers A, Wekerle H, Dornmair K, Hohlfeld R, Goebels N (2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc Natl Acad Sci USA 100(7): 4090-4095
Wiendl H, Mitsdoerffer M, HofmeisterV, Wischhusen J, Weiss EH, Dichgans J, Lochmüller H, Hohlfeld R, Melms A, Weller M (2003). The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy. Brain 126: 176-185
Theil D, Derfuss T, Paripovic I, Meinl E, Schueler O, Strupp M, Arbusow V, Brandt T (2003). Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response. Am J Pathol 163: 2179-2184
Dornmair K, Weltzien HU, Goebels N, Wekerle H, Hohlfeld R (2003). T-cell mediated autoimmunity: Novel techniques to characterize autoreactive T cell receptors. Am J Pathol 163: 1215-1226
Arbour N, Holz A, Sipe JC, Naniche D, Romine JS, Zyroff J, Oldstone MBA (2003). A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis. J Neuroimmunol 137: 197-209
Jenne DE, Tinschert S, Dorschner MO, Hameister H, Stephens K, Kehrer-Sawatzki H (2003). Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Gene Chromosome Canc 37: 111-120
Voltz R, Albrich W, Hohlfeld R, Nagel D, Wick M, Kirchner T, Sommer N, Illa I, Kaminski H, Schumm F (2003). Anti-titin antibodies are not associated with a specific thymoma histology. J Neurol Neurosurg Psychiat 74: 282
Wekerle H, Hohlfeld R. Molecular mimicry in multiple sclerosis (2003). New Engl J Med 349: 185-186, Editorial
Hohlfeld R(2003) Hunting (auto)immune T cells in neuroimmunological diseases. Brain 126: 2-4 , Editorial
Kerschensteiner M, Hohlfeld R (2003). Neurotrophic factors protect myelin from attack. Internat MS Journal 10: 2-4, Editorial
Dalakas M, Hohlfeld R. (2003). Polymyositis and dermatomyositis. Lancet 362: 971-982
Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R (2003). Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Ann Neurol 53: 292-304
Bradl M, Hohlfeld R (2003) Neuroscience for Neurologists: Molecular pathogenesis of neuroinflammation. J Neurol Neurosurg Psychiat 74: 1364-1370
Hohlfeld R, Dalakas M (2003). Basic principles of immunotherapy for neurologic diseases. Semin Neurolo 23: 121-131
2002
Abdul-Majid KB, Stefferl A, Bourquin C, Lassmann H, Linington C, Olsson T, Kleinau S, Harris RA (2002). Fc receptors are crititcal for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scand J Immunol 55: 70-81
Andersson M, Yu M, Soderstrom M, Weerth S, Baig S, Linington C, Solders G, Link H (2002). Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. Eur J Neurol 9:243-251
Bauer J, Bradl M, Klein M, Leisser M, Deckwerth TL, Wekerle H, Laßmann H (2002). Endoplasmic reticulum stress in PLP overexpressing transgenic rats: Gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Journal of Neuropathol Exp Neurol 61:12-22
Berninger B, Bi GQ (2002). Synaptic modification in neural circuits: a timely action. BioEssays 24: 212-222
Bradl M, Flügel A (2002). The role of T cells in brain pathology. Curr Top Microbiol Immunol 265: 141-62
Burger B, Uhlhaas S, Jenne D, Dockter G, Back W, Mangold E, Propping P, Friedl W (2002). Novel de novo mutation of MADH4/SMAD4 in a patient with juvenile polyposis. Am J Med Genet 110: 289-291
Campbel PK, Waymire KG, Heier RL, Shareer C, Day DE, Reimann H, Jaje JM, Friedrich GA, Burmeister M, Bartness TJ, Russell LD, Young LY, Zimmer M, Jenne DE, MacGregor GR (2002). Mutation of a novel gene results in abnormal development of spermatid flagella, loss of inter-male aggression and reduced body fat in mice. Genetics 162: 307-320
Clanet M, Radue EW, Kappos L, Hartung HP, Hohlfeld R, Sandberg-Wollheim M, Kooijmans-Coutinho MF, Tsao EC, Sandrock AW and the European IFNß-1a (Avonex) Dose-Comparison Study Investigators (2002). A randomised, double-blind, dose-comparison study of weekly interferon ß-1a in relapsing MS. Neurology 59: 1507-1517
Derfuß T, Meinl E (2002). Herpesviral proteins blocking apoptosis. Viral Proteins Counteracting Host Defenses, Koszinowski/Hengel (ed.). Curr Topics Microbiol Immunol 269: 257-268
Farina C, Vargas V, Heydari N, Kümpfel T, Meinl E, Hohlfeld R (2002). Treatment with glatiramer acetate induces specific IgG4 antibodies in multiple sclerosis patients. J Neuroimmunol 123:188-192
Farina C, Wagenpfeil S, Hohlfeld R (2002). Immunological assay for assessing the efficacy of glatiramer acetate (Copaxone) in multiple sclerosis: A pilot study. J Neurol 249: 1587-1592
Gold R, Linington C (2002). Devic’s disease: bridging the gap between laboratory and clinic. Brain 125: 1425-1427
Hammer MH, Schroder G, Risch K, Flugel A, Volk HD, Lehmann M, Ritter T (2002). Antigen-dependent transgene expression in kidney transplantation: a novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol 13: 511-8
Hohlfeld R (2002). How promising is hematopoetic stem cell transplantation in multiple sclerosis? J Neurol 249: 1147-1149
Hohlfeld R (2002). Myelin failure in multiple sclerosis: Breaking the spell of Notch. Nat Med 8: 1075-1076
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H (2002). Role of Lkb1, the causative gene of Peutz–Jegher’s syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 99: 8903-8908
Kirchhoff S, Sebens T, Baumann S, Krueger A, Zawatzky R, Li-Weber M, Meinl E, Neipel F, Fleckenstein B, Krammer PH (2002). Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter. J Immunol 168: 1226-1234
Klinkert WEF, Bode W, Jenne DE (2002). The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. Journal of Biol Chem 277(52): 50923-50933
Meinl E, Hohlfeld R (2002). Immunopathogenesis of Multiple Sclerosis: MBP and beyond. Clin Exp Immunol 128: 395-397
Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA (2002). Tumor necrosis factor inhibits outgrowth and branching of hippocampal neurons by a Rho-dependent mechanism. J Neurosci 22: 854-862
Oldstone, MBA, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R (2002). Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion. J Virol 76: 4357-4363
Panitch H, Goodin DS, Francis G, Chang P, Coyle PK, O´Connor P, Monaghan E, Li D, Weinshenker B, and the EVIDENCE Study Group and the University of British Columbia MS/MRI Research Group (2002). Randomized, comparative study of interferon ß-1a treatment regimes in MS: The EVIDENCE Trial. Neurology 59: 1496-1506
Popovic N, Schubart A, Goetz BD, Zhang SC, Linington C, Duncan ID (2002). Inhibition of autoimmune encephalomyelitis by a tetracycline. Ann Neurol 51: 215-223
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