Publications

2018

Goltstein PM, Reinert S, Glas A, Bonhoeffer T, Hübener M (2018). Food and water restriction lead to differential learning behaviors in a head-fixed two-choice visual discrimination task for mice. PLoS One 13(9): e0204066. doi:10.1371/journal.pone.0204066

Kaschube M, Nelson CA, Benasich AA, Buzsáki G, Gressens P, Hensch TK, Hübener M, Kobor MS, Singer W and Sur M (2018). Early Childhood. In A. A.Benasich and U.Ribary (eds): Emergent Brain Dynamics: Prebirth to Adolescence, pp 102-123. Cambridge, MA: The MIT Press. Series: Strüngmann Forum Reports, Vol.25

Weiler, S, Bauer J, Hübener M, Bonhoeffer T, Rose T, Scheuss V (2018). High-yield in vitro recordings from neurons functionally characterized in vivo. Nature Protocols 13:1275-1293. doi:10.1038/nprot.2018.026

2017

Jäpel J, Hübener M, Bonhoeffer T, Rose T (2017). Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice. Nat Neurosci 20: 1708-7014

Rose T, Hübener M (2017). Synapses get together for vision. News & Views. Nature 547:408-410

Clopath C, Bonhoeffer T, Hübener M, Rose T (2017). Variance and invariance of neuronal long-term representations. Phil. Trans. R. Soc. B 372:20160161. dx.doi.org/10.1098/rstb.2016.0161

Keck T, Hübener M, Bonhoeffer T (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Curr Opin Neurobiol 43:87-93. dx.doi.org/10.1016/j.conb.2017.02.003

Keck T, Toyoizumi T, Chen L, Doiron B, Feldman D, Fox K, Gerstner W, Haydon P, Hübener M, Lee H, Lisman J, Rose T, Sengpiel F, Stellwagen D, Stryker M, Turrigiano G, van Rossum M (2017). Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Phil. Trans. R. Soc. 372: 20160158. doi: 10.1098/rstb.2016.0158

2016

Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M* (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539:248-253
* equal contribution

Rose T, Jaepel J, Hübener M, Bonhoeffer T (2016). Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex. Science 352:1319-1322

Bonhoeffer T, Hübener M (2016). Intrinsic Optical Imaging of Functional Map Development in Mammalian Visual Cortex. Cold Spring Harb Protoc. 2016(6). doi: 10.1101/pdb.top089383

Liebscher S, Keller GB, Goltstein PM, Bonhoeffer T, Hübener M (2016). Selective persistence of sensorimotor mismatch signals in visual cortex of behaving Alzheimer's disease mice. Current Biol 26:956-964

2015

Goltstein P, Hübener M (2015). A division of light and dark in the visual cortex. Preview. Neuron 88:624-626

2014

Hübener M, Bonhoeffer T (2014). Neuronal plasticity: beyond the critical period. Cell 159: 727-737

Santos AF, Hübener M (2014). Chronic calcium imaging of neurons in the mouse visual cortex using a troponin C-based indicator. Cold Spring Harb Protoc. 2014(5). doi: 10.1101/pdb.prot081737

Leinweber M, Zmarz P, Buchmann P, Argast P, Hübener M, Bonhoeffer T, Keller GB (2014). Two-photon calcium imaging in mice navigating a virtual reality environment. J Vis Exp. (84). doi: 10.3791/50885

2013

Djurisic M, Vidal GS, Mann M, Aharon A, Kim T, Ferrao Santos A, Zuo Y, Hübener M, Shatz CJ (2013). PirB regulates a structural substrate for cortical plasticity. PNAS 110: 20771-20776

Keck T*, Keller GB*, Jacobsen RI*, Eysel UT, Bonhoeffer T, Hübener M (2013). Synaptic scaling and homeostatic plasticity in the mouse visual cortex in vivo. Neuron 80: 327-334 
* equal contribution

Liebscher S, Page R, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Guriqbal SB, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M (2013). Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry doi:10.1038/mp.2013.122

McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M (2013). Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathol. 126(2):179-88. doi: 10.1007/s00401-013-1137-2

2012

Tomita T, Sperling M, Cambridge SB, Bonhoeffer T, Hübener M (2012). A molecular correlate of ocular dominance columns in the developing mammalian visual cortex. Cereb. Cortex doi:10.1093/cercor/bhs232

Levelt CN, Hübener M (2012). Critical-period plasticity in the visual cortex. Annu Rev Neurosci 21: 309-330

Keller GB, Bonhoeffer T, Hübener M (2012). Sensorimotor mismatch signals in primary visual cortex of the behaving mouse. Neuron, 74: 809-815

2011

Ertürk A, Mauch CP, Hellal F, Förstner F, Keck T, Becker K, Jährling N, Steffens H, Richter M, Hübener M, Kramer E, Kirchhoff F, Dodt HU, Bradke F (2011). Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury. Nat Med. 18(1):166-71. doi: 10.1038/nm.2600

Kreile AK, Bonhoeffer T, Hübener M (2011). Altered visual experience induces instructive changes of orientation preference in mouse visual cortex. J Neurosci 31: 13911-13920

Keck T, Scheuss V, Jacobsen RI, Wierenga CJ, Eysel UT, Bonhoeffer T, Hübener M (2011). Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. Neuron 71: 869-882

2010

Hübener M, Bonhoeffer T (2010). Searching for Engrams. Neuron 67: 363-371. doi: 10.1016/j.neuron.2010.06.033

2009

Holtmaat A, Bonhoeffer T, Chow D, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee W-CA, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L (2009). Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nature Protocols 4: 1128-1144

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2009). Experience leaves a lasting structural trace in cortical circuits. Nature 457: 313-317

2008

Mank M, Ferrão Santos A, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T,  Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O (2008). A genetically encoded calcium indicator for chronic in vivo two photon imaging. Nature Methods 5: 805-811

Keck T, Mrsic-Flogel TD, Vaz Afonso M, Eysel UT, Bonhoeffer T, Hübener M (2008). Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci 11: 1162-1167

Hübener M, Hofer SB, Mrsic-Flogel TD (2008). Ocular dominance plasticity. In L.M.Chalupa and R.W.Williams (eds): Eye, Retina, and Visual System of the Mouse, pp 439-448. Cambridge, MA: MIT Press

2007

Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T and Hübener M (2007). Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron 54: 961-972

2006

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Lifelong learning: ocular dominance plasticity in mouse visual cortex. Curr Opin Neurobiol 16: 451-459

Ohki K, Chung S, Kara P, Hübener M, Bonhoeffer T, Reid RC (2006). Highly ordered arrangement of single neurons in orientation pinwheels. Nature 442: 925-929

Hofer SB, Mrsic-Flogel TD, Bonhoeffer T, Hübener M (2006). Prior experience enhances plasticity in adult visual cortex. Nat Neurosci 9: 127-132

2000 -2005

Mrsic-Flogel TD, Hofer SB, Creutzfeldt C, Cloez-Tayarani I, Changeux JP, Bonhoeffer T, Hübener M (2005). Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci 25: 6921-6928

Hübener M, Bonhoeffer T (2005). Visual cortex: two-photon excitement. Curr Biol. 15(6):R205-8

Hübener M (2003). Mouse visual cortex. Curr Opin Neurobiol 13: 413-420

Mrsic-Flogel T, Hübener M, Bonhoeffer T (2003). Brain mapping: new wave optical imaging. Curr Biol. 13(19):R778-80

Schuett S, Bonhoeffer T, Hübener M (2002). Mapping retinotopic structure in mouse visual cortex with optical imaging. J Neurosci 22: 6549-6559

Schuett S, Bonhoeffer T, Hübener M (2001). Pairing-induced changes of orientation maps in cat visual cortex. Neuron 32: 325-337

Swindale NV, Shoham D, Grinvald A, Bonhoeffer T, Hübener M (2000). Visual cortex maps are optimized for uniform coverage. Nat Neurosci 3: 822-826

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