Publications of Alexander Flügel

Journal Article (39)

2018
Journal Article
Zhang, B.; Watt, J. M.; Cordiglieri, C.; Dammermann, W.; Mahon, M. F.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease. Scientific Reports 8, 16775 (2018)
2012
Journal Article
Graeber, M. B.; Banati, R. B.; Flügel, A.; Streit, W. J.; Tetzlaff, W.: Courage, luck and patience: in celebration of the 80th birthday of Georg W. Kreutzberg [Editorial]. Acta Neuropathologica 124, pp. 593 - 598 (2012)
2010
Journal Article
Kawakami, N.; Flügel, A.: Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Seminars in Immunopathology 32 (3), pp. 275 - 287 (2010)
Journal Article
Volovitz, I.; Marmor, Y.; Mor, F.; Fluegel, A.; Odoardi, F.; Eisenbach, L.; Cohen, I. R.: T cell vaccination induces the elimination of EAE effector T cells: Analysis using GFP-transduced, encephalitogenic T cells. Journal of Autoimmunity 35 (2), pp. 135 - 144 (2010)
Journal Article
Cordiglieri, C.; Odoardi, F.; Zhang, B.; Nebel, M.; Kawakami, N.; Klinkert, W. E. F.; Lodygin, D.; Luhder, F.; Breunig, E.; Schild, D. et al.; Ulaganathan, V. K.; Dornmair, K.; Dammermann, W.; Potter, B. V. L.; Guse, A. H.; Flügel, A.: Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. Brain 133, pp. 1930 - 1943 (2010)
2009
Journal Article
Bartholomäus, I.; Kawakami, N.; Odoardi, F.; Schläger, C.; Miljkovic, D.; Ellwart, J. W.; Klinkert, W. E. F.; Flügel-Koch, C.; Issekutz, T. B.; Wekerle, H. et al.; Flügel, A.: Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 462 (7269), pp. 94 - 98 (2009)
Journal Article
Dammermann, W.; Zhang, B.; Nebel, M.; Cordiglieri, C.; Odoardi, F.; Kirchberger, T.; Kawakami, N.; Dowden, J.; Schmid, F.; Dornmair, K. et al.; Hohenegger, M.; Flügel, A.; Guse, A. H.; Potter, B. V. L.: NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proceedings of the National Academy of Sciences of the United States of America 106 (26), pp. 10678 - 10683 (2009)
2008
Journal Article
Kawakami, N.; Odoardi, F.; Bartholomäus, I.; Wekerle, H.; Flügel, A.: Intravital 2-photon imaging of autoreactive effector T cells invading the CNS in the initial phase of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 203 (2), pp. 236 - 237 (2008)
Journal Article
Mues, M.; Mank, M.; Griesbeck, O.; Odoardi, F.; Flügel, A.; Kurschus, F.; Wekerle, H.: Imaging activation: FRET-based calcium biosensors in T-lymphocytes. Journal of Neuroimmunology 203 (2), p. 230 - 230 (2008)
Journal Article
Matheu, M. P.; Beeton, C.; Garcia, A.; Chi, V.; Rangaraju, S.; Safrina, O.; Monaghan, K.; Uemura, M. I.; Li, D.; Pal, S. et al.; de la Maza, L. M.; Monuki, E.; Flügel, A.; Pennington, M. W.; Parker, I.; Chandy, K. G.; Cahalan, M. D.: Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block. IMMUNITY 29 (4), pp. 602 - 614 (2008)
Journal Article
Bartholomäus, I.; Schläger, C.; Brinkmann, V.; Wekerle, H.; Flügel, A.: Intravital 2-photon imaging of encephalitogenic effector cells during fingolimod (FTY720) treatment of experimental autoimmune encephalomyelitis. Multiple Sclerosis 14 (Suppl. Suppl. 1), pp. S30 - S31 (2008)
Journal Article
Odoardi, F.; Cordiglieri, C.; Dammermann, W.; Zhang, B.; Hohenegger, M.; Potter, B. V.; Guse, A.; Flügel, A.: NAADP/Ca2+ signaling: a new therapeutic target for T cell mediated autoimmune disease. Wiener Klinische Wochenschrift 120 (Suppl. Suppl. 1), p. 54 - 54 (2008)
Journal Article
Rooney, G. E.; Moran, C.; McMahon, S. S.; Ritter, T.; Maenz, M.; Flügel, A.; Dockery, P.; O'Brien, T.; Howard, L.; Windebank, A. J. et al.; Barry, F. P.: Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Engineering Part A 14 (5), pp. 681 - 690 (2008)
Journal Article
Müller, N.; van den Brandt, J.; Odoardi, F.; Tischner, D.; Herath, J.; Flügel, A.; Reichardt, H. M.: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats. Journal of Clinical Investigation 118 (4), pp. 1405 - 1416 (2008)
2007
Journal Article
Grundtner, R.; Dornmair, K.; Dahm, R.; Flügel, A.; Kawakami, N.; Zeitelhofer, M.; Schoderboeck, L.; Nosov, M.; Selzer, E.; Willheim, M. et al.; Kiebler, M.; Wekerle, H.; Lassmann, H.; Bradl, M.: Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system. Neurobiology of Disease 28 (3), pp. 261 - 275 (2007)
Journal Article
Odoardi, F.; Kawakami, N.; Klinkert, W. E. F.; Wekerle, H.; Flügel, A.: Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proceedings of the National Academy of Sciences of the United States of America 104 (47), pp. 18625 - 18630 (2007)
Journal Article
Flügel, A.; Odoardi, F.; Nosov, M.; Kawakami, N.: Autoaggressive effector T cells in the course of experimental autoimmune encephalomyelitis visualized in the light of two-photon microscopy. Journal of Neuroimmunology 191 (1-2), pp. 86 - 97 (2007)
Journal Article
Becton, C.; Matheu, M. P.; Uemura, M.; Pennington, M. W.; Flügel, A.; Parker, I.; Cahalan, M. D.; Chandy, K. G.: Live imaging of effector memory T cells at a site of inflammation - a kv1.3 blocker suppresses T cell motility. FASEB Journal 21 (6), p. A770 - A770 (2007)
Journal Article
Odoardi, F.; Kawakami, N.; Li, Z. X.; Cordiglieri, C.; Streyl, K.; Nosov, M.; Klinkert, W. E. F.; Ellwart, J. W.; Bauer, J.; Lassmann, H. et al.; Wekerle, H.; Flügel, A.: Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America 104 (3), pp. 920 - 925 (2007)
Journal Article
Gong, N.; Pleyer, U.; Vogt, K.; Anegon, I.; Flügel, A.; Volk, H.-D.; Ritter, T.: Local over-expression of nerve growth factor in corneal transplants improves allograft survival. Investigative Ophthalmology & Visual Science 48, pp. 1043 - 1052 (2007)
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