Contact

Tobias Bonhoeffer, PhD
Tobias Bonhoeffer, PhD
Director
Phone:+49 89 8578-3751

Office: Meike Hack

Research Movies

How the brain is wired up

Tobias Bonhoeffer and his team investigate the neurobiological foundation of learning and memory.

Department portrait

Publications

Department: Synapses – Circuits – Plasticity

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Synapses – Circuits – Plasticity

Research overview

One of the most fundamental properties of the brain is its ability to adapt rapidly to environmental changes. This is mainly achieved by changes in the connectivity between individual nerve cells. Synapses, the connection elements between neurons, can be modulated in their strength by a variety of different mechanisms, a process called "synaptic plasticity".

We investigate the fundamental principles of synaptic plasticity at a number of different levels, ranging from molecular approaches to studies of the intact nervous system. Recent results from our lab have shown that synaptic plasticity is accompanied by structural changes of dendritic spines, they have demonstrated that these structural changes are the reason why re-learning of information acquired early in life is comparatively easy, and they have revealed in how far the detailed structure of functional maps in the visual cortex is due to experience in the outside world.

During development, specific connections among neurons within the visual cortex are established. However, even in the adult brain, this network is able to adapt to new demands. We investigate the cellular mechanisms enabling this plasticity in the developing and adult brain.

Visual system plasticity (Mark Hübener, PhD)

During development, specific connections among neurons within the visual cortex are established. However, even in the adult brain, this network is able to adapt to new demands. We investigate the cellular mechanisms enabling this plasticity in the developing and adult brain.
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Project Groups

With increasing knowledge about information processing in the intact brain it becomes evident how strongly social factors influence computations and storage of information. To shine light on the underlying processes we are studying the influence of social interactions between mice and their pups on learning behavior. We are using pup-retrieval behavior to shine light on the impact of pup calls onto the structure and function of auditory cortex neurons in mothers and foster mothers. Specifically, we investigate how cortical circuit wiring and neural network activity changes during acquisition of parental care behavior. Finally, both datasets will be brought together to generate a coherent interpretation of the relationship between structural and functional plasticity during natural behavior

Impact of social learning on cortical neurons

With increasing knowledge about information processing in the intact brain it becomes evident how strongly social factors influence computations and storage of information. To shine light on the underlying processes we are studying the influence of social interactions between mice and their pups on learning behavior. We are using pup-retrieval behavior to shine light on the impact of pup calls onto the structure and function of auditory cortex neurons in mothers and foster mothers. Specifically, we investigate how cortical circuit wiring and neural network activity changes during acquisition of parental care behavior. Finally, both datasets will be brought together to generate a coherent interpretation of the relationship between structural and functional plasticity during natural behavior
[more]
It is known, that learning leads to the formation of new synaptic connections between individual nerve cells. Yet it is unclear whether these structural changes are specific enough to take part in forming a neuronal ‘memory trace’. We study both in vivo and in vitro how learning-induced changes in the response properties of individual neurons and synapses relate to changes in their structure.

Structural and functional plasticity of individual synapses

It is known, that learning leads to the formation of new synaptic connections between individual nerve cells. Yet it is unclear whether these structural changes are specific enough to take part in forming a neuronal ‘memory trace’. We study both in vivo and in vitro how learning-induced changes in the response properties of individual neurons and synapses relate to changes in their structure.

[more]
 
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