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Genes - Circuits - Behavior

Research overview

All sensory perception and every coordinated movement, as well as feelings, memories and motivation, arise from the bustling activity of many millions of interconnected cells in the CNS. The ultimate function of this elaborate network is to generate behavior. The goal of our research is to understand how animal brains integrate the information about sensory inputs and internal state into behavioral responses. We use zebrafish as our experimental model, employing a diverse array of methods. Our approaches take advantage of the feature that zebrafish larvae are optically transparent and genetically accessible. The goal of our research is to understand how neuronal circuits convert sensory inputs into behavioral responses.

Projects

Cellular-resolution map of the larval zebrafish brain
We are mapping the long-range connectivity of the zebrafish brain and address the question of how many discrete neuron types exist.
Optical, genetic and computational methods for circuit analysis
We devise and adapt a wide variety of technologies to investigate how neural circuits process information and generate behavior.
Molecules, Cells, Circuits
We are applying single-cell transcriptomics to identify neuronal cell types based on their gene expression profiles and determine their spatial distribution and connectivity in the intact brain.
Vision to action
Specific visual stimulus configurations release particular behaviors. We investigate how visual stimuli are transformed to motor outputs.
Social (re-)cognition
We study the neural and genetic underpinnings of cognition, motivation and emotion in the fish brain.
Optic flow processing
Fumi Kubo group

We discovered that the zebrafish brain distinguishes between two types of optic flow. Our aim is to understand the wiring diagram serving this task.
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